Anethol, cinnamaldehyde, and eugenol inclusion in feed affects postweaning performance and feeding behavior of piglets1

Blavi, Laia; Solà-Oriol, David; Mallo, J. J.; Pérez, J. F.

doi:10.2527/jas.2016-0760

Cited by 30 publications

(46 citation statements)

References 31 publications

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“…Therefore, eugenol has the potential to be an alternative to AGP, by preventing and alleviating the inflammatory gut diseases caused by weaning stress. Additionally, the flavor of eugenol in feeds positively affects postweaning performance and A c c e p t e d M a n u s c r i p t 6 feeding behavior of piglets, which helped piglets adapt to a novel solid food from liquid (Blavi et al, 2016).…”

Section: Introductionmentioning

confidence: 99%

Eugenol attenuates inflammatory response and enhances barrier function during lipopolysaccharide-induced inflammation in the porcine intestinal epithelial cells

Hui

Ammeter

Liu

et al. 2020

Journal of Animal Science

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Eugenol (4-allyl-2-methoxyphenol) is an essential oil component, possessing anti-microbial, anti-inflammatory and anti-oxidative properties, however the effect of eugenol on porcine gut inflammation has not yet been investigated. In this study, an in vitro lipopolysaccharide (LPS)-induced inflammation model in porcine intestinal epithelial cells (IPEC-J2) has been set up. Cells were pre-treated with 100 μM (16.42 mg/L) eugenol for 2 h followed by 10 μg/mL LPS stimulation for 6 h. Pro-inflammatory cytokine secretion, reactive oxygen species, gene expression of pro-inflammatory cytokines, tight junction proteins and nutrient transporters, the expression and distribution of zonula occludens-1 (ZO-1), trans-epithelial electrical resistance (TEER) and cell permeability were measured to investigate the effect of eugenol on inflammatory responses and gut barrier function. The results showed that eugenol pre-treatment significantly suppressed the LPS-stimulated interleukin 8 (IL-8) level and the mRNA abundance of tumor necrosis factor α (TNF-α); restored the LPS-stimulated decrease of mRNA abundance of tight junction proteins zonula occludens-1 (ZO-1), occludin (OCLN) and the mRNA abundance of nutrient transporters B0-system neutral amino acid co-transporter (B0AT1), system ASC sodium-dependent neutral amino acid exchanger 2 (ASCT2), apical sodium-dependent glucose transporter 1 (SGLT1), excitatory amino acid transporter 1 (EAAC1) and peptide transporter 1 (PepT1). In addition, eugenol improved the expression and even redistribution of ZO-1 and tended to increase TEER value and maintained the barrier integrity. In conclusion, a low dose of eugenol attenuated inflammatory responses and enhanced selectively permeable barrier function during LPS-induced inflammation in the IPE-J2 cell line.

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Section: Introductionmentioning

confidence: 99%

Eugenol attenuates inflammatory response and enhances barrier function during lipopolysaccharide-induced inflammation in the porcine intestinal epithelial cells

Hui

Ammeter

Liu

et al. 2020

Journal of Animal Science

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“…The findings of the current study suggest that early feeding experiences can have long-lasting effects on feed preferences, at least up to two weeks after the treatments were not reinforced anymore. Our findings are consistent with previous studies, who also reported differences in short-(during dietary treatment) and long-term feeding preferences (after end of dietary treatments) in piglets exposed to different diets early in life (Figueroa et al, 2013;Blavi et al, 2016;Clouard et al, 2016).…”

supporting

confidence: 93%

“…The balance between aversion and acceptance of flavoured creep feed in piglets seems complex, as feed intake of either a familiar or unfamiliar flavour is variable (e.g. Langendijk et al, 2007;Figueroa et al, 2013;Blavi et al, 2016). These inconsistent results indicate that it is hard to predict whether a flavour increases acceptance of the feed or results in aversion and reduced feed intake.…”

Section: Discussionmentioning

confidence: 99%

“…Most studies show, against expectations, that flavour learning does not stimulate creep feed intake when the flavours are also given in the creep feed (e.g. prenatal flavour exposure: Figueroa et al, 2019Figueroa et al, , 2013; perinatal flavour exposure: Langendijk et al, 2007;postnatal flavour exposure: Millet et al, 2008), with one study that found increased creep feed intake for one out of the three tested flavours (postnatal flavour exposure: Wang et al, 2014) and one study that found increased creep feed intake for the unflavoured creep feed (perinatal flavour learning: Blavi et al, 2016). In a choice setting, piglets also preferred the control creep feed over the creep feed flavoured with the flavour that was added to the sow's feed in late gestation (Figueroa et al, 2013).…”

Section: A Matter Of Taste and Texturementioning

confidence: 99%

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Foraging in the farrowing room to stimulate feeding : getting piglets to eat is bittersweet

Middelkoop¹

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In common pig production systems, weaning happens early and abruptly, which contrasts the gradual transition from sow's milk to solid feed in nature. A significant proportion of commercially reared piglets is therefore poorly familiarised with the ingestion of solid feed before weaning, which together with concurrent changes in social structure and environment, result in a low feed intake and multiple health and welfare problems initially after weaning. The first aim of this thesis was to investigate the effects of solid feed provision during lactation (creep feed) on piglet development during the weaning transition. Piglets provided with creep feed (including fermentable fibres) during lactation increased their growth towards weaning, tended to be heavier at weaning, and were heavier and more uniform in body weight at two weeks after weaning compared to piglets reared on sow's milk only. This may partly be explained by a more developed gastrointestinal tract and more mature gut microbiota population at weaning of creep feed eaters within litters given creep feed. The second aim of this thesis was to explore whether piglets that were offered more opportunities to forage early in life increased their intake of creep feed before weaning and thereby improved their ability to deal with the weaning transition. Four strategies that could stimulate foraging in the farrowing room were tested: 1) enriching the pen with foraging materials on the floor and extra space, and by alternating chew objects, 2) presenting creep feed in a 'play-feeder' with foraging and playing materials attached, 3) providing diverse feeds in the feeder and 4) hiding feed in the feeder in sand. Enrichment with foraging materials on the floor, more space and alternating chew objects positively influenced feed intake of piglets before and after weaning until the end of the study at 2.5 weeks postweaning. Presenting the creep feed in a play-feeder stimulated feeder exploration and attracted more piglets than presenting the feed in a conventional feeder. Although the play-feeder did not enhance pre-weaning feed intake, post-weaning feed intake and growth were substantially improved and the incidence of diarrhoea, body lesions and damage were lower. Simultaneous provision of diverse feeds to suckling piglets resulted in more feed exploration and solid feed intake, and in a higher number of good eaters. Hiding feed in sand stimulated the number of good creep feed eaters within the litter, but did not increase exploration towards the feed. With the exception of the first feeding strategy, treatments were not reinforced after weaning and piglets thus experienced loss of these resources, which may have had a negative effect on post-weaning adaptation. This may explain the limited effects of dietary diversity on post-weaning adaption and the negative effects of hiding feed in sand on post-weaning feed intake, growth, manipulation and aggression. Lastly, it was shown that creep feed intake is not only driven by exploration, but also by a low energy intake fr...

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“…Recent studies have shown the transfer of PC such as anethole, cinnamaldehyde, eugenol [25], limonene and carvone [15] from the feed to amniotic uid of sows during gestation, with effects on reproductive performance and mammary secretions [14], as well as, the antioxidant status in gestating sows [26]. The results of the present study are in line with such ndings with the relative increase of BPC limonene, anethole, borneol, p-cymene, and eucalyptol in the sow's amniotic uid compared to the Control group.…”

Section: Prenatal Effects Of Bpc On Sows and Their Offspringmentioning

confidence: 99%

Neonatal programming of piglet gut health and postnatal effects by maternal transfer of phytogenic compounds supplemented in gestating and lactating hyperprolific sows

Reyes-Camacho¹,

Pérez²,

Vinyeta³

et al. 2020

Preprint

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Background The improvement of sow prolificacy by breeding has increased the number of piglets produced per sow per year. However, intrauterine crowding and/or intrauterine growth restriction typically observed in hyperprolific sows impairs foetal growth which has decreased the average individual birthweight, with a larger proportion of low birthweight (LBW) pigs born per litter with poor gut development and compromised postnatal growth performance. Phytogenic compounds (PC) are plant-derived natural bioactive substances that can be used in livestock production as feed additives to promote animal health and production efficiency. This research aims to study if a specific blend of PC (BPC) supplemented in gestating and lactating hyperprolific sow diets may promote pre- and postnatal maternal effects on performance and oxidative status of sows and their offspring, colostrum-milk features, and piglet gut health-related gene expression and morphology. Forty DanBred hybrid line Landrace x Yorkhire gilts and sows (parities 0–7) were randomly allocated by parity number and body weight into two dietary treatments including unsupplemented Control (n = 20) or Control diets supplemented with 1 g/kg feed of BPC (n = 20) throughout gestation and lactation.Results Several dietary PC from the supplemented BPC were transferred to the placental fluid and milk. The BPC supplementation during gestation enhanced the litter size, antioxidant status, and colostrum protein content of sows. Jejunal histomorphology of neonate piglets, and intestinal-function gene expression related to nutrient transport, antioxidant, innate immune response, and digestion were improved in the BPC group. For both, sows and piglets, plasma antioxidant activity of CAT and SOD enzymes were enhanced. For suckling piglets, jejunal expression of genes related to gut barrier function was improved and piglet weight gain from birth to weaning was enhanced in the BPC group.Conclusions Dietary supplementation of BPC in gestating and lactating diets for hyperprolific sows improves sow’s reproductive performance and colostrum composition, with a significant strength of the antioxidant status of sows and their offspring. The prenatal and postnatal maternal transfer (placental fluid and milk) of BPC to the offspring would influence on the neonatal programming and postnatal of piglet’s gut health, with advantageous effects on piglet’s growth performance.

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Anethol, cinnamaldehyde, and eugenol inclusion in feed affects postweaning performance and feeding behavior of piglets1

Cited by 30 publications

References 31 publications

Eugenol attenuates inflammatory response and enhances barrier function during lipopolysaccharide-induced inflammation in the porcine intestinal epithelial cells

Eugenol attenuates inflammatory response and enhances barrier function during lipopolysaccharide-induced inflammation in the porcine intestinal epithelial cells

Foraging in the farrowing room to stimulate feeding : getting piglets to eat is bittersweet

Neonatal programming of piglet gut health and postnatal effects by maternal transfer of phytogenic compounds supplemented in gestating and lactating hyperprolific sows

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