Anetoderma in a Systemic Lupus erythematosus Patient with Anti-PCNA and Antiphospholipid Antibodies

Álvarez‐Cuesta, César Cosme; Raya-Aguado, Cristina; Fernández-Rippe, María Luisa; Sanchez, T. Soler; Pérez‐Oliva, Narciso

doi:10.1159/000051789

Cited by 13 publications

(11 citation statements)

References 9 publications

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“…23 Associated conditions. Secondary anetoderma has been associated with urticaria pigmentosa, 24 syphilis, 25 acne, 26 varicella, 27 Lyme disease, 28 leprosy, 29 HIV infection, 30,31 lymphoproliferative disorders, 32,33 Langerhans cell histiocytosis, 34 systemic lupus erythematosus, 14,35,36 primary hypothyroidism, 37 Graves disease, 38 Addison disease, 14 antiphospholipid syndrome, 39 Sjögren syndrome, 40 prurigo nodularis, 41 pilomatricoma, 42,43 application of leeches, 44 electrocardiographic lead placement, 45 hepatitis B vaccination, 46 chronic angular cheilitis, 47 congenital melanocytic nevi with hamartomatous features, 48 juvenile xanthogranuloma, 49 and generalized granuloma annulare. 50 Involvement of extracutaneous elastic tissue has not been reported.…”

Section: Anetodermamentioning

confidence: 99%

Acquired disorders of elastic tissue: Part II. decreased elastic tissue

Lewis

Bercovitch

Dill

et al. 2004

Journal of the American Academy of Dermatology

171

216

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Section: Anetodermamentioning

confidence: 99%

Acquired disorders of elastic tissue: Part II. decreased elastic tissue

Lewis

Bercovitch

Dill

et al. 2004

Journal of the American Academy of Dermatology

171

216

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“…Despite this fact, a definitive relationship between LE and anetoderma has not been proven. However, the association between anetoderma and APAs has been documented previously (5,6,11,12), as well as a relationship between LE and APAs (5,6,11,13,14). Stephansson & Niemi (11), reviewing a group of SLE patients with and without APAs, observed that 15% of those with positive APAs developed anetoderma, while none of those without these antibodies developed this skin condition.…”

Section: Discussionmentioning

confidence: 88%

Anetodermic Lupus Panniculitis and Antiphospholipid Antibodies: Report of Three Cases

Marzano¹,

Vanotti²,

Alessi³

2004

Acta Dermato-Venereologica

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Anetoderma is a rare cutaneous disease characterized by a loss of normal elastic tissue that is presented clinically as localized areas of wrinkled or flaccid skin. This form may be associated with several immunological abnormalities, most notably lupus erythematosus and antiphospholipid antibodies with or without clinical manifestations of the antiphospholipid syndrome. A retrospective study was conducted with the aim of summarizing the clinical characteristics, course and laboratory findings in three women with anetoderma-associated lupus erythematosus panniculitis, an unusual variant of cutaneous lupus erythematosus. The 3 patients (of the 12 patients with lupus erythematosus panniculitis seen by us since 1990) were all at a young age at onset of panniculitis (median, 22 years). None of the patients developed severe systemic involvement up to 9 years (median, 5 years) from onset of the disease. The most noteworthy laboratory finding was the presence of antiphospholipid antibodies. Anetodermic lupus erythematosus panniculitis may be regarded as an uncommon variant of cutaneous lupus erythematosus mainly affecting young females and showing a favourable clinical course, although the patients should be followed and screened for the emergence of antiphospholipid syndrome. Antiphospholipid antibodies could play a role in the elastolytic process, leading to anetoderma.

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“…Antiphospholipid antibodies have been reported to associate with several cutaneous diseases in which vascular abnormalities seem to play a major part. Recently, nonvascular, cutaneous diseases including melanoma and anetoderma have been reported in patients with antiphospholipid antibodies [6, 7, 8]. To our knowledge, these are the first reported cases of subcutaneous GP associated with antiphospholipid antibodies.…”

Section: Discussionmentioning

confidence: 96%

Subcutaneous Granuloma pyogenicum in Patients with Antiphospholipid Antibodies

Kuroda

Mizoguchi

2004

Dermatology

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We describe 2 cases of subcutaneous granuloma pyogenicum occurring in patients with antiphospholipid antibodies. The 2 patients had asymptomatic nodules with histopathological findings of a typical subcutaneous granuloma pyogenicum. In addition, case 1 was diagnosed as primary antiphospholipid syndrome with livedo reticularis, superficial thrombophlebitis, thrombocytopenia, cerebral and pulmonary infarcts and renal involvement. Case 2 had no clinical manifestations of vascular occlusive diseases, although anticardiolipin antibody levels were highly positive. To our knowledge, these are the first reported cases of subcutaneous granuloma pyogenicum associated with antiphospholipid antibodies. Antiphospholipid-antibody-mediated thrombosis or immunological mechanisms may be involved in subcutaneous granuloma pyogenicum in our cases.

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Anetoderma in a Systemic Lupus erythematosus Patient with Anti-PCNA and Antiphospholipid Antibodies

Cited by 13 publications

References 9 publications

Acquired disorders of elastic tissue: Part II. decreased elastic tissue

Acquired disorders of elastic tissue: Part II. decreased elastic tissue

Anetodermic Lupus Panniculitis and Antiphospholipid Antibodies: Report of Three Cases

Subcutaneous Granuloma pyogenicum in Patients with Antiphospholipid Antibodies

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