Anetodermic mastocytosis: Response to PUVA therapy

Pozo, Jesús del; Pimentel, M. T. Yebra; Paradela, Sabela; Almagro, Manuel; Martínez, Walter; Fonseca, Eduardo

doi:10.1080/09546630701258093

Cited by 7 publications

(4 citation statements)

References 21 publications

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“…It is reported that mast cells can be directly or indirectly affected by UV radiation (75)(76)(77). Our study contributes to the field by showing that the number of histochemically detectable perifollicular mast cells is decreased while their degranulation is increased 1 day after irradiation of the skin surface with UVA and UVB.…”

Section: Discussionsupporting

confidence: 52%

“…Mast cells are important regulators of hair growth and may be functionally important for the maintenance of human HF immune privilege and HF responses to oxidative damage . It has been shown that mast cells are highly affected by UVR , and that UVR or psoralen plus UVA therapy can be beneficial for patients affected by mast cell‐driven skin disorders . Therefore, we were particularly interested in how low or high UVR modulates perifollicular mast cell activities, i.e.…”

Section: Resultsmentioning

confidence: 99%

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Transepidermal UV radiation of scalp skin ex vivo induces hair follicle damage that is alleviated by the topical treatment with caffeine

Gherardini

Wegner

Chéret

et al. 2019

Intern J of Cosmetic Sci

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ObjectivesAlthough the effect of ultraviolet radiation (UVR) on human skin has been extensively studied, very little is known on how UVR impacts on hair follicle (HF) homeostasis. Here, we investigated how solar spectrum UVR that hits the human skin surface impacts on HF biology, and whether any detrimental effects can be mitigated by a widely used cosmetic and nutraceutical ingredient, caffeine.MethodsHuman scalp skin with terminal HFs was irradiated transepidermally ex vivo using either 10 J/cm2 UVA (340–440 nm) + 20 mJ/cm2 UVB (290–320 nm) (low dose) or 50 J/cm2 UVA + 50 mJ/cm2 UVB (high dose) and organ‐cultured under serum‐free conditions for 1 or 3 days. 0.1% caffeine (5.15 mmol/L) was topically applied for 3 days prior to UV exposure with 40 J/cm2 UVA + 40 mJ/cm2 UVB and for 3 days after UVR. The effects on various toxicity and vitality read‐out parameters were measured in defined skin and HF compartments.ResultsConsistent with previous results, transepidermal UVR exerted skin cytotoxicity and epidermal damage. Treatment with high and/or low UVA+UVB doses also induced oxidative DNA damage and cytotoxicity in human HFs. In addition, it decreased proliferation and promoted apoptosis of HF outer root sheath (ORS) and hair matrix (HM) keratinocytes, stimulated catagen development, differentially regulated the expression of HF growth factors, and induced perifollicular mast cell degranulation. UVR‐mediated HF damage was more severe after irradiation with high UVR dose and reached also proximal HF compartments. The topical application of 0.1% caffeine did not induce skin or HF cytotoxicity and stimulated the expression of IGF‐1 in the proximal HF ORS. However, it promoted keratinocyte apoptosis in selected HF compartments. Moreover, caffeine provided protection towards UVR‐mediated HF cytotoxicity and dystrophy, keratinocyte apoptosis, and tendential up‐regulation of the catagen‐promoting growth factor.ConclusionOur study highlights the clinical relevance of our scalp UV irradiation ex vivo assay and provides the first evidence that transepidermal UV radiation negatively affects important human HF functions. This suggests that it is a sensible prophylactic strategy to integrate agents such as caffeine that can act as HF photoprotectants into sun‐protective cosmeceutical and nutraceutical formulations.

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Section: Discussionsupporting

confidence: 52%

Section: Resultsmentioning

confidence: 99%

Transepidermal UV radiation of scalp skin ex vivo induces hair follicle damage that is alleviated by the topical treatment with caffeine

Gherardini

Wegner

Chéret

et al. 2019

Intern J of Cosmetic Sci

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“…Anetodermic lesions are an unusual clinical presentation of mastocytosis. 16,17 MCs play an important role in the development of anetodermic lesions, as they release different mediators which interfere with collagen synthesis and increase the fragmentation of elastic fibers. Moreover, the chemotactic substances released during mastocyte degranulation induce the accumulation of eosinophils, neutrophils and macrophages, which might promote elastase activity.…”

Section: Discussionmentioning

confidence: 99%

Adult mastocytosis: a review of the Santo António Hospital 's experience and an evaluation of World Health Organization criteria for the diagnosis of systemic disease

Fernandes¹,

Teixeira

Freitas

et al. 2014

An. Bras. Dermatol.

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BACKGROUNDMastocytosis is a clonal disorder characterized by the accumulation of abnormal mast cells in the skin and/or in extracutaneous organs. OBJECTIVESTo present all cases of mastocytosis seen in the Porto Hospital Center and evaluate the performance of World Health Organization diagnostic criteria for systemic disease. METHODSThe cases of twenty-four adult patients with mastocytosis were reviewed. Their clinical and laboratorial characteristics were assessed, and the properties of the criteria used to diagnose systemic mastocytosis were evaluated. RESULTSThe age of disease onset ranged from 2 to 75 years. Twenty-three patients had cutaneous involvement and 75% were referred by dermatologists. Urticaria pigmentosa was the most common manifestation of the disease. One patient with severe systemic mast cell mediator-related symptoms showed the activating V560G KIT mutation. The bone marrow was examined in 79% of patients, and mast cell immunophenotyping was performed in 67% of the participants. Systemic disease was detected in 84% of cases, and 81% of the sample had elevated serum tryptase levels. All the diagnostic criteria for systemic mastocytosis had high specificity and positive predictive value. Bone marrow biopsy had the lowest sensitivity, negative predictive value and efficiency, while the highest such values were observed for mast cell immunophenotyping. Patients were treated with regimens including antihistamines, sodium cromoglycate, alpha-interferon, hydroxyurea and phototherapy. CONCLUSIONSCutaneous involvement is often seen in adult mastocytosis patients, with most individuals presenting with indolent systemic disease. Although serum tryptase levels are a good indicator of mast cell burden, bone marrow biopsy should also be performed in patients with normal serum tryptase, with flow cytometry being the most adequate method to diagnose systemic disease.

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“…We performed a literature review using PubMed and Google Scholar search with the keywords “PUVA” and “mastocytosis” for the period from 1970 to 2017. Twenty‐three studies were identified (Table ), most of them reported improvement of pruritus, 2 Darier sign, cutaneous lesions, and/or a decrease in the appearance of new lesions in more than 50% of patients. Nevertheless, only 25% of mastocytosis patients had improvement of skin symptoms for >5 years after cessation of PUVA .…”

Section: Characteristic Features Of Patients With Mastocytosismentioning

confidence: 99%

Efficacy of PUVA in Russian patients with mastocytosis: a case series and review of literature

et al. 2018

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Anetodermic mastocytosis: Response to PUVA therapy

Cited by 7 publications

References 21 publications

Transepidermal UV radiation of scalp skin ex vivo induces hair follicle damage that is alleviated by the topical treatment with caffeine

Transepidermal UV radiation of scalp skin ex vivo induces hair follicle damage that is alleviated by the topical treatment with caffeine

Adult mastocytosis: a review of the Santo António Hospital 's experience and an evaluation of World Health Organization criteria for the diagnosis of systemic disease

Efficacy of PUVA in Russian patients with mastocytosis: a case series and review of literature

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