Aneurysmal Bone Cyst at the base of the Skull

Abstract

Aneurysmal bone cysts have been described as pseudocysts in view of their lack of an epithelial lining. These cysts are uncommon, but when they do occur they typically involve the long bones of the extremities, the membranous bones of the thorax and pelvis, and the vertebrae. Skull involvement is uncommon. We present the case of a 14-year-old girl who presented with nasal obstruction and a swelling of the right cheek. Contrast-enhanced computed tomography detected a heterogeneous cystic mass involving the sphenoid and ethmoid bones. The mass was excised via a lateral rhinotomy approach, and it was identified as an aneurysmal bone cyst on histologic examination. The patient experienced a recurrence in the right sphenoid sinus within 3 months, and the lesion was removed via transnasal endoscopy.

Massive aneurysmal bone cyst of the skull base treated with denosumab

“…1,2,[18][19][20][21][22][23] This is usually associated with resolution of symptoms and an uneventful postoperative course; however, recurrences have been reported. Other options include the use of cement, phenol, cryotherapy, and sclerotherapy.…”

“…1,2,[18][19][20][21][22][23] This is usually associated with resolution of symptoms and an uneventful postoperative course; however, recurrences have been reported. 19,21,22 Denosumab has been reported to provide meaningful clinical and radiological improvement in aneurysmal bone cysts. [24][25][26] Denosumab is a monoclonal antibody to RANKL that prevents it binding to its receptor RANK.…”

Giant Aneurysmal Bone Cyst of the Anterior Cranial Fossa and Paranasal Sinuses Presenting in Pregnancy: Case Report and Literature Review

“… 2 Lesions involving the skull are rare, comprising only 3 to 6% of all ABCs. 3 ABCs have been reported to involve both the neurocranium (ethmoidal and/or sphenoidal, 10 11 12 13 14 15 16 17 18 temporal, 19 20 21 22 23 24 25 26 27 28 29 30 occipital, 21 31 32 33 34 35 parietal, 36 37 frontal, 12 38 39 40 41 ) and viscerocranium (mandible, 42 maxilla, 43 and zygoma 44 ).…”

Fibro-Osseous Lesions of the Skull Base in the Pediatric Population

“…Other authors have published case reports of these lesions affecting the anterior skull base. [10][11][12] ABCs have also been noted to develop in the setting of fibrous dysplasia and JOF (►Fig. 3).…”