Aneurysmal coronary artery disease.

Swaye, Paul S.; Fisher, Lloyd D.; Litwin, Paul E.; Vignola, Paul A.; Judkins, Melvin P.; Kemp, Harvey G.; Mudd, J. Gerard; Gosselin, Arthur J.

doi:10.1161/01.cir.67.1.134

Cited by 883 publications

(910 citation statements)

References 17 publications

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“…This finding agrees with the results published in several previous studies, in which it has been widely shown that CAE co-exists with CAD approximately in 85% of cases [3,[13][14][15][16][17]. The right coronary artery was the most involved artery in the coronary artery ectasia followed by the anterior descending artery and the circumflex artery [2,13,18,19].…”

Section: Discussion:-supporting

confidence: 91%

Matrix Metalloproteinases and Coronary Artery Ectasia.

Levantino¹,

Raspanti²,

Evola³

et al. 2017

IJAR

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Background: Coronary artery ectasia is the abnormal dilatation of one or more coronary segments. Although the pathogenetic mechanisms underlying CAE are largely unknown, it seems that some of the extracellular matrix degrading enzymes such as matrix metalloproteinases (mmps) can play an important role in the development of this condition. The aim of our study was to evaluate the relationship between MMP-9 and the development of CAE as well as the role played by the inflammatory process in this condition. Materials And Methods: In our retrospective study we have enrolled a series of 79 patients: 47 presented, on coronary angiography, focal or diffuse ectasia of coronary arteries (cases), 32 had a free coronary tree or without hemodynamically significant stenosis (controls). All patients were subjected to blood sampling for the dosage of MMP-9 and Creactive protein (CRP). Results: In our study we found that the most involved coronary artery in CAE was the right coronary artery. Serum levels of MMP-9 were higher in the patients with CAE (5.011 mcg / ml vs. 3.93 mcg / ml, p = 0,07) although not statistically significant, in direct proportion to the number of involved vessels (p = 0.025). Serum CRP levels were higher in patients with CAE (5.12 mg / dl vs. 2.18 mg / dl, p = 0.4) although not statistically significant, in direct proportion to the number of involved vessels (p = 0.001). Conclusions: We found a possible relationship between elevated levels of MMP-9 and CAE, as well as the relationship between levels of MMP-9 and severity of the CAE. Furthermore we found a possible relationship between elevated CRP levels and CAE and there was a directly proportional relationship between the increase of CRP and extension of the CAE.

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Section: Discussion:-supporting

confidence: 91%

Matrix Metalloproteinases and Coronary Artery Ectasia.

Levantino¹,

Raspanti²,

Evola³

et al. 2017

IJAR

View full text Add to dashboard Cite

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“…CAE has been defined as localized or diffuse non-obstructive lesions of one epicardial coronary artery with a luminal dilatation exceeding the 150% of a normal adjacent vessel diameter [4]. It is characterized by an abnormal dilatation of coronary artery, represents a form of atherosclerotic coronary artery disease, seen in 3-8% of patients undergoing coronary angiography [1].…”

Section: Discussionmentioning

confidence: 99%

A Rare Occurrence of Congenital Coronary Ectasia Combined with Ventricular Septal Defect

Huang¹,

Wen²,

Chien³

2017

J Clin Exp Cardiolog

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Idiopathic or congenital coronary artery ectasia (CAE) is an uncommon form of coronary artery disease. In adults, coronary artery ectasia is usually associated with atherosclerotic change and is well recognized clinical entity encountered during cardiac catheterization. Coronary artery dilatation in pediatric is usually associated with the sequelae of Kawasaki disease. Congenital coronary artery ectasia is uncommon and rarely reported in children. We present a case of an infant who have dilated coronary artery, she also had ventricular septal defect (VSD) and heart failure who had received VSD repair at infancy. There was no obstructive coronary artery disease, and no cause for the lesions could be identified. The prognosis and optimal management of such patients remains unknown. Antiplatelet therapy might be necessary for the patient to remain free of myocardiac ischemia.

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“…In this regard, Guy et al showed increased prevalence of CAE in patients with abdominal aortic aneurysms (10). Most risk factors of CAE are similar to coronary artery stenosis (CAS), including cigarette smoking, male gender, hypertension (HTN), positive family history of coronary artery disease, elevated CRP and hyperhomocysteinemia (2,(11)(12)(13). Interestingly, diabetes mellitus (DM) is significantly lower in CAE patients in comparison to CAS group (11,14).…”

Section: Introductionmentioning

confidence: 99%