Femoral veins have been used as a substitute graft for limb bypass in selected patients. The long-term efficacy of deep-vein grafts in neoaortoiliac system reconstruction has been shown to be excellent but the efficacy in extremity bypass is still unclear. Here, we report a case of subclavian-to-brachial artery bypass surgery using a femoral vein graft in a chronically immunocompromised patient with previous kidney transplantation. The patient remains symptom-free at 5 years with a patent bypass without any complications, such as aneurysmal dilatation, recurrent infection, stenosis or harvested limb oedema. The femoral vein would be a good option for extremity bypass in patients with high-risk immune problems when other veins are not available.