Angelica gigas Nakai extract-loaded fast-dissolving nanofiber based on poly(vinyl alcohol) and Soluplus for oral cancer therapy

Nam, Suyeong; Lee, Jeong-Jun; Lee, Song Yi; Jeong, Jae Young; Kang, Wen; Cho, Hyun‐Jong

doi:10.1016/j.ijpharm.2017.05.004

Cited by 50 publications

(23 citation statements)

References 38 publications

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“…AGN Ex was obtained from AGN by the reported methods [ 24 , 26 , 27 , 28 , 29 ]. In short, AGN was dried at 55 °C for 1 day.…”

Section: Methodsmentioning

confidence: 99%

“…The encapsulation efficiency values of D/DA (in AGN NPs) and D/DA/RSV (in AGN/RSV NPs) were quantitatively determined by the high-performance liquid chromatography (HPLC) system as reported [ 24 , 26 , 27 , 32 ]. AGN Ex was dissolved in methanol (MeOH) at 1 mg/mL and standard samples of AGN Ex were prepared by serial dilution with MeOH.…”

Section: Methodsmentioning

confidence: 99%

“…Among diverse phytomedicines for cancer prevention and therapy [ 16 , 17 , 18 ], the pharmacological effects of single components and extracts of Angelica gigas Nakai (AGN) have been widely investigated [ 19 ]. The main components of AGN, such as decursin (D) and decursinol angelate (DA), and its extracts have anticancer potentials in several types of cancers, such as breast, blood, cervical, colon, lung, oral, ovarian, prostate, and skin cancers [ 20 , 21 , 22 , 23 , 24 , 25 , 26 ]. In our previous studies [ 22 , 24 , 26 ], AGN extract and AGN particles have shown anticancer activities in breast, buccal, and cervical cancers.…”

Section: Introductionmentioning

confidence: 99%

“…For the simultaneous delivery of diverse components of AGN Ex, single nanocarriers considering their different physicochemical characteristics should be designed. In our previous reports [ 24 , 26 , 27 , 28 , 29 ], several pharmaceutical technologies (that is, hot-melt extrusion, microemulsion, electrospraying/electrospinning, and emulsification-solvent evaporation) have been introduced to prepare the formulations of AGN powder or AGN Ex. Of note, polymer matrix-free AGN nanocomposites (NCs) were fabricated by introducing the nanocrystal preparation protocol [ 24 ].…”

Section: Introductionmentioning

confidence: 99%

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Development of Resveratrol-Loaded Herbal Extract-Based Nanocomposites and Their Application to the Therapy of Ovarian Cancer

et al. 2018

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Resveratrol (RSV) and the ethanol extract of Angelica gigas Nakai (AGN Ex)-based nanoparticles (NPs) were prepared using the nanocrystal concept. AGN/RSV NPs with 224 nm hydrodynamic size, unimodal size distribution, and negative zeta potential values were developed with the emulsification and solvent evaporation techniques. The crystalline properties of AGN Ex and RSV were transformed during the emulsification and solvent evaporation processes, thus, AGN NPs and AGN/RSV NPs exhibited amorphous states. AGN/RSV NPs held up their initial hydrodynamic size after 24 h of incubation in serum-included media. Sustained release profiles (for 5 days) of decursin (D) and decursinol angelate (DA) (the representative markers of AGN Ex) and RSV were observed at normal physiological pH (pH 7.4). In ovarian cancer (SKOV-3) cells, although AGN/RSV NPs showed a lower cellular entry rate rather than AGN NPs, the cellular accumulated amount of AGN/RSV NPs was similar with that of AGN NPs after 4 h of incubation. The antiproliferation efficiency of AGN/RSV NPs group was significantly higher than the AGN Ex, AGN NPs, and AGN NPs + RSV groups in SKOV-3 cells. AGN/RSV NPs can be one of the promising candidates for therapeutic nanoplatforms against ovarian cancers.

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“…AGN Ex was obtained from AGN by the reported methods [ 24 , 26 , 27 , 28 , 29 ]. In short, AGN was dried at 55 °C for 1 day.…”

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Development of Resveratrol-Loaded Herbal Extract-Based Nanocomposites and Their Application to the Therapy of Ovarian Cancer

et al. 2018

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“…Numerous researchers have been studying orodispersible or fast-dissolving drug delivery formulations produced from nanofiber-loaded systems that rapidly disintegrate in the oral cavity due to nanofibers' large surface area, which causes immediate disintegration in water solutions and fast drug release [18,[39][40][41][42][43][44][45][46]. Applications of the electrospinning technique on modified per oral drug delivery are summarized in Table 2.…”

Section: Electrospinning In Per Oral Drug Deliverymentioning

confidence: 99%

Electrospinning and Drug Delivery

Vlachou¹,

Siamidi²,

Kyriakou³

2019

Electrospinning and Electrospraying - Techniques and Applications

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A detailed account of the construction, properties, and practical applications of electrospinning for the fabrication of high-quality ultrafine fibers, suitable for drug delivery, is given. With respect to the electrospinning method, various parameters are of crucial importance. The electrospinning parameters are classified as solution properties, process parameters, and environmental conditions. The solution properties include the polymer concentration, molecular weight and viscosity, the solution conductivity and relative volatility, volatility of the solvent, surface tension, and dielectric constant. The process parameters refer to the flow rate, the applied voltage, the needle diameter, and the distance between the tip of the needle and collector and the geometry of the collector. The environmental conditions include the relative humidity and temperature. All these factors are responsible for a flawless electrospinning process, which leads to the formation of the desirable electrospun nanofibers with the requisite characteristics. In this chapter, it has been shown that the electrospinning technology could provide a useful method for modifying drug release behavior and opens new routes for the development of effective and tailormade drug release carriers.

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Delivery of a mitochondria‐targeted antioxidant from biocompatible, polymeric nanofibrous scaffolds

et al. 2020

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Cardiovascular disease has been associated with increased levels of reactive oxygen species (ROS). Recently, we have shown that a critical balance between cytosolic ROS and mitochondrial ROS is crucial in cardiovascular health and that modulation of mitochondrial ROS helps prevent detrimental effects of cytosolic ROS on endothelial cells (EC) in transgenic animals. Here, we report the development of a controlled delivery system for a mitochondria-targeted antioxidant, JP4-039, from an electrospun scaffold made of FDA-approved biocompatible polymeric nanofibers. We demonstrate that the active antioxidant moiety was preserved in released JP4-039 for over 72 h using electron paramagnetic resonance. We also show that both the initial burst release of the drug within the first 20 min and the ensuing slow and sustained release that occurred over the next 24 h improved tube formation in human coronary artery ECs (HCAEC) in vitro. Taken together, these findings suggest that electrospinning methods can be used to upload mitochondrial antioxidant (JP4-039) onto a biocompatible nanofibrous PLGA scaffold, and the uploaded drug (JP4-039) retains nitroxide antioxidant properties upon release from the scaffold, which in turn can reduce mitochondrial ROS and improve EC function in vitro. Cardiovascular disease, including ischemic heart disease and myocardial infarction (MI), is the leading cause of death in the world. One of the major consequences of MI is death of cardiomyocytes leading to cardiac remodeling, fibrosis, and heart failure [1]. There are major efforts undergoing to improve blood supply to the ischemic myocardium by inducing the growth or sprouting of new blood vessels, that is, angiogenesis, from the existing coronary vessels. Recent work from our laboratory and others showed that reactive oxygen species (ROS) plays a major role in determining coronary vascular endothelial cell (EC) proliferation, migration, and tube formation in vitro [2-5]. ECs have several intracellular sources for ROS, including membrane-bound NADPH oxidases, mitochondria, peroxisome, and cytochrome P450 [6-12]. Whereas the increase in ROS is believed to be harmful for the cardiovascular system, the use of global

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Angelica gigas Nakai extract-loaded fast-dissolving nanofiber based on poly(vinyl alcohol) and Soluplus for oral cancer therapy

Cited by 50 publications

References 38 publications

Development of Resveratrol-Loaded Herbal Extract-Based Nanocomposites and Their Application to the Therapy of Ovarian Cancer

Development of Resveratrol-Loaded Herbal Extract-Based Nanocomposites and Their Application to the Therapy of Ovarian Cancer

Electrospinning and Drug Delivery

Delivery of a mitochondria‐targeted antioxidant from biocompatible, polymeric nanofibrous scaffolds

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