Angelica keiskei, an emerging medicinal herb with various bioactive constituents and biological activities

Abstract

Angelica keiskei (Miq.) Koidz. (Umbelliferae) has traditionally been used to treat dysuria, dyschezia, and dysgalactia as well as to restore vitality. Recently, the aerial parts of A. keiskei have been consumed as a health food. Various flavonoids, coumarins, phenolics, acetylenes, sesquiterpene, diterpene, and triterpenes were identified as the constituents of A. keiskei. The crude extracts and pure constituents were proven to inhibit tumor growth and ameliorate inflammation, obesity, diabetics, hypertension, and ulcer. The extract also showed anti-thrombotic, anti-oxidative, anti-hyperlipidemic, anti-viral, and anti-bacterial activities. This valuable herb needs to be further studied and developed not only to treat these human diseases but also to improve human health. Currently A. keiskei is commercialized as a health food and additives in health drinks. This article presents a comprehensive review of A. keiskei and its potential place in the improvement of human health.

Plants-Derived Biomolecules as Potent Antiviral Phytomedicines: New Insights on Ethnobotanical Evidences against Coronaviruses

“…Angelica keiskei ( A. keiskei ) belongs to the family of Umbelliferae, and its leaves are basically used for remedial purposes [ 147 ]. Its bioactive components include chalcones, flavanones and coumarins, coumarins phenolic, acetylenes, sesquiterpene, diterpene, and triterpenes [ 144 , 146 ]. A. keiskei is known and considered to be antiviral, anticancer, anti-inflammatory, anti-obesity, anti-oxidative, anti-coagulant, anti-tumor, anti-mutagenic, anti-diabetic, antibacterial and hepato-protective [ 144 , 145 , 146 ].…”

“…Its bioactive components include chalcones, flavanones and coumarins, coumarins phenolic, acetylenes, sesquiterpene, diterpene, and triterpenes [ 144 , 146 ]. A. keiskei is known and considered to be antiviral, anticancer, anti-inflammatory, anti-obesity, anti-oxidative, anti-coagulant, anti-tumor, anti-mutagenic, anti-diabetic, antibacterial and hepato-protective [ 144 , 145 , 146 ]. Park et al, 2016 extracted bioactive components (9 alkylated chalcones and 4 coumarins) from A. keiskei plant [ 146 ], and revealed that the extracted chalcones were able to significantly block the entry of coronavirus (SARS-CoV-1) by inhibiting the chymotrypsin-like protease (75% inhibition using 30 µg/mL dose) and a papain-like protease (88% inhibition using 30 µg/mL dose) [ 146 ].…”

Daily Supplementation with Fresh Angelica keiskei Juice Alleviates High‐Fat Diet‐Induced Obesity in Mice by Modulating Gut Microbiota Composition

“…Angelica keiskei Koidz (of the family Umbelliferae) is a cold‐hardy perennial plant that was originally grown on the Izu Islands and Miura Peninsula of Japan. The aerial parts (leaves and stems) have been consumed for centuries as a healthy vegetable because of its beneficial effects, including anti‐tumor, anti‐obesity, anti‐diabetic, and anti‐inflammatory effects . A. keiskei has a unique phytochemical profile.…”

Non-surgical treatment with XSHHD for ruptured lumbar disc herniation: a 3-year prospective observational study

“…Modern pharmacological studies have shown that Huang Qi can improve the immune response, promote the proliferation of Schwann cells, accelerate axonal growth, and improve nerve regeneration repair functio n [31,32]. Dang Gui can expand blood vessels, and promote blood circulation and the growth of new blood vessels in prominent tissue s [33]. Fang Ji is believed to have anti-inflammatory and analgesic effects, and to be involved in dehydration and relieving swelling, as well as muscle relaxation and regulating autoimmunity.…”