Angelica oil restores the intestinal barrier function by suppressing S100A8/A9 signalling in mice with ulcerative colitis

Liu, Chang; He, Yue-Xian; Zhang, Jianing; Long, Yongling; Wang, Shuyuan; Hu, Jiliang; Yu, Yang

doi:10.1016/j.phymed.2022.154490

Cited by 11 publications

(1 citation statement)

References 37 publications

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“…After the ingestion of walnut oil, the expression levels of tight junction (TJ)-related proteins in colonic tissue increased in colitis mice, and walnut oil reversed the loss of TJ-related proteins induced by inflammation [70]. Flaxseed oil, algal oil, and angelica oil have also been found to have a protective effect on the intestinal barrier [65,87,91]. This indicates that restoring intestinal barrier function is one of the targets of natural oils in improving IBD.…”

Section: Protecting the Intestinal Barriermentioning

confidence: 99%

The Potential of Natural Oils to Improve Inflammatory Bowel Disease

et al. 2023

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Inflammatory bowel disease (IBD) is a chronic intestinal inflammatory disorder that includes ulcerative colitis (UC) and Crohn’s disease (CD), the exact cause of which is still unknown. Numerous studies have confirmed that diet is one of the major environmental factors associated with IBD, as it can regulate the gut microbiota and reduce inflammation and oxidative stress. Since the consumption of oil is essential in the diet, improving IBD through oil has potential. In this article, we first briefly reviewed the current treatment methods for IBD and introduce the role of natural oils in improving inflammatory diseases. We then focused on the recent discovery of the role of natural oils in the prevention and treatment of IBD and summarized their main mechanisms of action. The results showed that the anti-inflammatory activity of oils derived from different plants and animals has been validated in various experimental animal models. These oils are capable of improving the intestinal homeostasis in IBD animal models through multiple mechanisms, including modulation of the gut microbiota, protection of the intestinal barrier, reduction in colonic inflammation, improvement in oxidative stress levels in the intestine, and regulation of immune homeostasis. Therefore, dietary or topical use of natural oils may have potential therapeutic effects on IBD. However, currently, only a few clinical trials support the aforementioned conclusions. This review emphasized the positive effects of natural oils on IBD and encouraged more clinical trials to provide more reliable evidence on the improvement of human IBD by natural oils as functional substances.

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