Angelica sinensis in China-A review of botanical profile, ethnopharmacology, phytochemistry and chemical analysis

Wei, Wenlong; Zeng, Rui; Gu, Cai-Mei; Qu, Yan; Huang, Linfang

doi:10.1016/j.jep.2016.05.023

Cited by 274 publications

(209 citation statements)

References 117 publications

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“…The root of Angelica sinensis (dang gui) has long been utilized as health food in Asia and dietary supplements for women’s care in Europe to relieve pain, nourish blood, and strengthen body organs. The main bioactive constituents, such as phthalides, organic acid, and polysaccharides are responsible for the anti‐inflammatory, antioxidant, antifibrotic, antispasmodic and neuroprotective properties (Wei, Zeng, Gu, Qu, & Huang, ). Auricularia auricula‐judae (wood ear mushroom) is rich in hetero‐polysaccharides with various pharmacological effects, such as radical scavenging, antioxidative, hypolipidemic, antitumor, and blood pressure regulation (Zhang et al, ).…”

Section: Introductionmentioning

confidence: 99%

Effect of in vitro digestion on the total polyphenol and flavonoid, antioxidant activity and carbohydrate hydrolyzing enzymes inhibitory potential of selected functional plant‐based foods

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2019

J Food Process Preserv

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This study aimed to investigate the effect of in vitro digestion on the total antioxidant activity and carbohydrate hydrolyzing enzymes inhibitory potential of 12 functional plant‐based foods. Undigested Centella asiatica showed the highest total antioxidant activity, phenolic and flavonoid content while Morus Alba and Dioscorea polystachya displayed the highest α‐glucosidase and α‐amylase inhibitory potential, respectively. In vitro digestion significantly (p < 0.05) increased the radical scavenging and carbohydrate hydrolyzing enzymes inhibitory activities in all plant extracts. Both phenolic (r = 0.840, p < 0.001) and flavonoid (r = 0.549, p < 0.01) contents were positively correlated with the total antioxidant activity. The activity in the aerial part of plants were significantly affected by digestion process when compared to tuber part. Principle component analysis showed that in vitro digestion contributed to 47% of total activity variation. In vitro digestion could induce the reducing power, radical scavenging, and carbohydrate hydrolyzing enzymes inhibitory potential of functional plant‐based foods involving fruit, flower, seed, root, and tuber. Practical applications Functional plant‐based foods with promising therapeutic potential are widely consumed in Southeast Asia countries either as raw ingredient or food additives due to their health‐oriented composition and good environmental sustainability. Comparison of antioxidant activity and carbohydrate hydrolyzing enzymes inhibitory potential of functional plant‐based foods before and after in vitro digestion could reveal the importance of food digestion process in modulating their health benefit. This study shows that in vitro digestion process could produce functional plant‐based food products with high antioxidant and carbohydrate hydrolyzing enzymes inhibitory activity which are potential alternatives to control postprandial hyperglycemia in the early stage of type 2 diabetes with minimal side effect. The data could also serve as a reference for both consumers and food manufacturers who favor the use of functional plants as food ingredient, additives, or flavoring in food processing for health promoting purpose.

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Section: Introductionmentioning

confidence: 99%

Effect of in vitro digestion on the total polyphenol and flavonoid, antioxidant activity and carbohydrate hydrolyzing enzymes inhibitory potential of selected functional plant‐based foods

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2019

J Food Process Preserv

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“…Diels, one of the most famous Chinese herbal medicines. It has been used in China for thousands of years and can be traced back to the Qin and Han dynasties (300 AD) (Wei, Zeng, Gu, Qu, & Huang, ). The chemical composition of DG is complex, with a variety of active ingredients, including polysaccharides, volatile oils, organic acids, phthalides and others (Chao & Lin, ; Wei et al, ).…”

Section: Introductionmentioning

confidence: 99%

Metabolomics study on promoting blood circulation and ameliorating blood stasis: Investigating the mechanism of Angelica sinensis and its processed products

Yuan

Zhong

Hua

et al. 2019

Biomedical Chromatography

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Angelica sinensis (Danggui, DG) parched with alcohol (Jiu Danggui, JDG) and charred DG are the main processed products of DG, which are used to treat blood stasis syndrome (BSS). However, their therapeutic effect and mechanisms are still unclear. Based on an acute rat BSS model, the intervention effects of DG and its processed products (DGPPs) were evaluated by the hemorheology and coagulation function parameters. Meanwhile, plasma and urine metabolites were detected and analyzed by liquid chromatography coupled to quadrupole time‐of‐flight mass spectrometry and multivariate statistical analysis method. The results of hemorheology, coagulation function parameters and metabolomics all showed that the BSS model was successfully established, DGPPs intervention could significantly relieve rats BSS and the therapeutic effect of JDG was best. Moreover, 23 differential metabolites (14 in plasma and nine in urine) were identified that were closely related to the BSS, involving seven potential target metabolic pathways. DGPP intervention showed different degrees of reverse effect on these metabolites. JDG was the most effective owing to extensive regulation effect on differential metabolites. This study provides a reference for understanding the pathological mechanism of BSS and the mechanism of DGPPs, which lays a theoretical foundation for the rational use of DGPPs in clinical practice.

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“…MAPKs, PI3K, and AKT, as HSP90 client chaperones, could regulate cell apoptosis, autophagy, proliferation, neural plasticity, and cell survival, indicating that MAPK and PI3K-AKT signal pathways played critical roles in the nervous system [40][41][42]. Previous studies suggested that the apoptosis-related and autophagy-related proteins, such as Bcl-2, Bax, LC3, and cleaved caspase 3, involved in the MAPKs and PI3K-AKT signal pathways.…”

Section: Discussionmentioning

confidence: 99%

Uncaria rhynchophylla Ameliorates Parkinson’s Disease by Inhibiting HSP90 Expression: Insights from Quantitative Proteomics

Lan

Zhou

Liu

et al. 2018

Cell Physiol Biochem

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Background/Aims: Uncaria rhynchophylla, known as “Gou-teng”, is a traditional Chinese medicine (TCM) used to extinguish wind, clear heat, arrest convulsions, and pacify the liver. Although U. rhynchophylla has a long history of being often used to treat central nervous system (CNS) diseases, its efficacy and potential mechanism are still uncertain. This study investigated neuroprotective effect and the underlying mechanism of U. rhynchophylla extract (URE) in MPP⁺-induced SH-SY5Y cells and MPTP-induced mice. Methods: MPP⁺-induced SH-SY5Y cells and MPTP-induced mice were used to established Parkinson’s disease (PD) models. Quantitative proteomics and bioinformatics were used to uncover proteomics changes of URE. Western blotting was used to validate main differentially expressed proteins and test HSP90 client proteins (apoptosis-related, autophagy-related, MAPKs, PI3K, and AKT proteins). Flow cytometry and JC-1 staining assay were further used to confirm the effect of URE on MPP⁺-induced apoptosis in SH-SY5Y cells. Gait analysis was used to detect the behavioral changes in MPTP-induced mice. The levels of dopamine (DA) and their metabolites were examined in striatum (STR) by HPLC-EC. The positive expression of tyrosine hydroxylase (TH) was detected by immunohischemical staining and Western blotting. Results: URE dose-dependently increased the cell viability in MPP⁺-induced SH-SY5Y cells. Quantitative proteomics and bioinformatics results confirmed that HSP90 was an important differentially expressed protein of URE. URE inhibited the expression of HSP90, which further reversed MPP⁺-induced cell apoptosis and autophagy by increasing the expressions of Bcl-2, Cyclin D1, p-ERK, p-PI3K p85, PI3K p110α, p-AKT, and LC3-I and decreasing cleaved caspase 3, Bax, p-JNK, p-p38, and LC3-II. URE also markedly decreased the apoptotic ratio and elevated mitochondrial transmembrane potential (DΨ_m). Furthermore, URE treatment ameliorated behavioral impairments, increased the contents of DA and its metabolites and elevated the positive expressions of TH in SN and STR as well as the TH protein. Conclusions: URE possessed the neuroprotective effect in vivo and in vitro, regulated MAPK and PI3K-AKT signal pathways, and inhibited the expression of HSP90. U. rhynchophylla has potentials as therapeutic agent in PD treatment.

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Angelica sinensis in China-A review of botanical profile, ethnopharmacology, phytochemistry and chemical analysis

Cited by 274 publications

References 117 publications

Effect of in vitro digestion on the total polyphenol and flavonoid, antioxidant activity and carbohydrate hydrolyzing enzymes inhibitory potential of selected functional plant‐based foods

Effect of in vitro digestion on the total polyphenol and flavonoid, antioxidant activity and carbohydrate hydrolyzing enzymes inhibitory potential of selected functional plant‐based foods

Metabolomics study on promoting blood circulation and ameliorating blood stasis: Investigating the mechanism of Angelica sinensis and its processed products

Uncaria rhynchophylla Ameliorates Parkinson’s Disease by Inhibiting HSP90 Expression: Insights from Quantitative Proteomics

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