Angelicosides I-IV, four undescribed furanocoumarin glycosides from Angelica dahurica roots and their tyrosinase inhibitory activities

Genus Angelica is one of the widely distributed and well-known genera of family Umbelliferae. It is utilized mainly by Chinese and Korean populations especially in their folk medicine. Angelica comprises a lot of medicinally important phytoconstituents such as coumarins, furanocoumarins, flavonoids, essential oils, verbascosides, polysaccharides, etc. Members of this genus play important roles, namely antioxidant, anti-inflammatory, anti-microbial, anti-diabetic, skin-whitening, cytotoxic, hepatoprotective, and many others. This review draws attention to many species of genus Angelica with much focus on A. dahurica being one of the highly medicinally used species within this genus.

show abstract

“…Four furanocoumarins were isolated, namely angelicosides I-III and angelicoside IV (Figure 2). [78].…”

Section: Essential Oil (Table 2)mentioning

confidence: 99%

Phytochemical Constituents, Folk Medicinal Uses, and Biological Activities of Genus Angelica: A Review

et al. 2022

View full text Add to dashboard Cite

show abstract

“…Tyrosinase plays a crucial role in melanogenesis 24 . The human skin contains melanocytes below the hair follicles and basal epidermis.…”

Section: Resultsmentioning

confidence: 99%

Grape seed proanthocyanidin extract inhibits DNA and protein damage and labile iron, enzyme, and cancer cell activities

Habib

El‐Fakharany

Kheadr

et al. 2022

Sci Rep

View full text Add to dashboard Cite

Grape seed extract from (Vitis vinifera) (VGSE) is an excellent source of various polyphenols that exhibit highly potent antioxidant and disease prevention properties. Although numerous biological activities, with potential for improving human health, have been reported for VGSE, there is a lack of data relating to the health benefits of VGSE on DNA damage, protein damage, labile iron activity, and enzyme inhibitory effects. This investigation demonstrated, for the first time, that VGSE inhibits DNA and BSA damage and labile iron activity in-vitro. Moreover, VGSE also inhibited in-vitro activities of AChE, tyrosinase, and α-amylase. VGSE treatment significantly reduced viability of MCF-7, Hep-G2, Caco-2, and Huh-7 cells after 48-h treatments. The results obtained provide additional support for the purported health benefits of VGSE and reinforce its potential in disease prevention and therapy, especially in relation to cancer.

show abstract

“…In addition to the compounds mentioned above, adenosine (309) was also isolated from the root of A. dahurica (Table 5 and Supplementary Figure S3) (Shu et al, 2020b). Moreover, A. dahurica also contains sucrose and amino acids (Zhao and Yang, 2018).…”

Section: Other Compoundsmentioning

confidence: 99%

The Angelica dahurica: A Review of Traditional Uses, Phytochemistry and Pharmacology

Zhao¹,

Feng

Wang

et al. 2022

Front. Pharmacol.

View full text Add to dashboard Cite

Angelica dahurica (A. dahurica) root is a famous edible medicinal herb that has been used in China for thousands of years. To date, more than 300 chemical constituents have been discovered from A. dahurica. Among these ingredients, coumarins and volatile oils are the major active compounds. Moreover, a few other compounds have also been isolated from the root of A. dahurica, such as alkaloids, phenols, sterols, benzofurans, polyacetylenes and polysaccharides. Modern pharmacological studies demonstrated that the root of A. dahurica and its active components displayed various bioactivities such as anti-inflammation, anti-tumor, anti-oxidation, analgesic activity, antiviral and anti-microbial effects, effects on the cardiovascular system, neuroprotective function, hepatoprotective activity, effects on skin diseases and so on. Based on these studies, this review focused on the research publications of A. dahurica and aimed to summarize the advances in the traditional uses, phytochemistry and pharmacology which will provide reference for the further studies and applications of A. dahurica.

show abstract

Angelicosides I-IV, four undescribed furanocoumarin glycosides from Angelica dahurica roots and their tyrosinase inhibitory activities

Cited by 13 publications

References 20 publications

Phytochemical Constituents, Folk Medicinal Uses, and Biological Activities of Genus Angelica: A Review

Phytochemical Constituents, Folk Medicinal Uses, and Biological Activities of Genus Angelica: A Review

Grape seed proanthocyanidin extract inhibits DNA and protein damage and labile iron, enzyme, and cancer cell activities

The Angelica dahurica: A Review of Traditional Uses, Phytochemistry and Pharmacology

Contact Info

Product

Resources

About