This study aimed to investigate the relationship between personal resources, depression, recovery motivation, and the mediating role of depression among drug abusers. It samples 50 individuals identified with drug abuse problems aged between 16 to 35 years who participated in a treatment programme for drug abuse problems in Cure and Care Rehabilitation Centres. Data were collected through a self-report questionnaire using five instruments: The Patient Health Questionnaire (PHQ), Rosenberg Self-Esteem Scale (RSES), Alcohol Abstinence Self-Efficacy Scale (AASE), The Life Orientation Scale (TLOS), and Commitment to Sobriety (CSS). Data were analysed through SPSS 23 and Partial Least Square-Structural Equation Modelling (PLS-SEM). In the path model, the results demonstrate that personal resources are significantly associated with depression. The finding indicates the significant reciprocal relationship between depression and recovery motivation. The results of this study also reveal the importance of depression in mediating the relationship between personal resources and recovery motivation. This study proposes that high levels of depression could potentially decrease the possibility of recovery motivation in an individual. It can also be concluded that a significant relationship exists between personal resources, depression, and recovery motivation, with depression as a mediator among individuals with drug addiction. These findings imply that mental health issues should also be considered in the treatment plan for people with drug abuse so an individual’s resources can be maximised and their recovery motivation enhanced.