Angiocentric Glioma: A Review of Clinicopathologic Features

Prayson, Richard A.

doi:10.21926/obm.neurobiol.1804015

Cited by 4 publications

(1 citation statement)

References 24 publications

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“…Although tumor progress was inhibited in terms of surgery and adjuvant therapies, the survival time of patients with malignant tumors has hardly changed [20,21]. Currently, the standard of care for glioblastoma patients is only palliative, with a median survival of approximately 12–15 months [22,23]. Glioma exhibits high recurrence of migration and invasion rates by activating important signal pathways such as receptor tyrosine kinases, PI3K/AKT/mTOR and RAS/RAF/MAPK pathways [24].…”

Section: Discussionmentioning

confidence: 99%

Knockdown circular RNA circGFRA1 inhibits glioma cell proliferation and migration by upregulating microRNA-99a

Cao

Zhang

et al. 2021

NeuroReport

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Glioma is the most widespread and malignant brain tumor in the central nervous system of adult, causing multiple cancer-associated deaths worldwide. Here, we identified the impact of circGFRA1 on glioma, and aimed to uncover the underlying molecular mechanism. The expression of circGFRA1 of glioma specimens was evaluated by using quantitative reverse transcription PCR. Cell viability, proliferation, colony formation, apoptosis and migration were estimated utilizing CCK-8, EdU staining, colony formation assay, TUNEL staining and Transwell assay, respectively. Bioinformatics analysis, luciferase assay and RNA co-immunoprecipitation was utilized for verification of direct binding between circGFRA1 and miR-99a. Western blot was applied to investigate protein expression in U251 cells. The results showed that circGFRA1 expression was overexpressed in glioma specimens. Knockdown circGFRA1 declined viability, colony formation, proliferation and migrative potential, but enhanced U251 cell apoptosis. Moreover, circGFRA1 acts as a microRNA sponge for miR-99a. Furthermore, miR-99a was involved in the circGFRA1-regulated glioma cell behaviors. Silencing circGFRA1 reduced p/t-AKT, p/t-FOXO1 and p/t-mTOR expression levels via upregulating miR-99a expression.In conclusion, our study demonstrated that knockdown circGFRA1 inhibits glioma cell proliferation and migration by upregulating microRNA-99a.

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Section: Discussionmentioning

confidence: 99%

Knockdown circular RNA circGFRA1 inhibits glioma cell proliferation and migration by upregulating microRNA-99a

Cao

Zhang

et al. 2021

NeuroReport

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Suppression of store-operated Ca²⁺ entry regulated by silencing Orai1 inhibits C6 glioma cell motility via decreasing Pyk2 activity and promoting focal adhesion

Zhu

et al. 2020

Cell Cycle

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Neuroradiological and pathomorphological features of epilepsy associated brain tumors

Khalilov¹,

Холин²,

Кисляков³

et al. 2021

Lučevaâ diagn. ter.

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Brain tumors are the second most common etiology in pediatric patients with focal seizures undergoing surgery for drug-resistant epilepsy. These neoplasms have a number of distinctive features from those found in adult patients, one of which is a wide polymorphism of structural architectonics during neuroradiological examination. Given the tremendous biological stability of these tumors, not in all cases of pre-surgical examination it is possible to verify the presence of a neoplastic process in the structure of the epileptogenic substrate using routine neuroimaging methods. In some complex diagnostic cases, a multimodal imaging approach and in-depth complex examination are required for reliable diagnosis and success of the results of epileptic surgery.

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Angiocentric Glioma: A Review of Clinicopathologic Features

Cited by 4 publications

References 24 publications

Knockdown circular RNA circGFRA1 inhibits glioma cell proliferation and migration by upregulating microRNA-99a

Knockdown circular RNA circGFRA1 inhibits glioma cell proliferation and migration by upregulating microRNA-99a

Suppression of store-operated Ca²⁺ entry regulated by silencing Orai1 inhibits C6 glioma cell motility via decreasing Pyk2 activity and promoting focal adhesion

Neuroradiological and pathomorphological features of epilepsy associated brain tumors

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Angiocentric Glioma: A Review of Clinicopathologic Features

Cited by 4 publications

References 24 publications

Knockdown circular RNA circGFRA1 inhibits glioma cell proliferation and migration by upregulating microRNA-99a

Knockdown circular RNA circGFRA1 inhibits glioma cell proliferation and migration by upregulating microRNA-99a

Suppression of store-operated Ca2+ entry regulated by silencing Orai1 inhibits C6 glioma cell motility via decreasing Pyk2 activity and promoting focal adhesion

Neuroradiological and pathomorphological features of epilepsy associated brain tumors

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Suppression of store-operated Ca²⁺ entry regulated by silencing Orai1 inhibits C6 glioma cell motility via decreasing Pyk2 activity and promoting focal adhesion