Angiocentric nasal T/natural killer cell lymphoma: a single centre study of prognostic factors in 108 patients

Abstract

Angiocentric T cell/natural killer (NK) nasal lymphoma remains a rare clinical presentation in North America and Europe but is more common in Asia and Latin America. We have reviewed 108 cases of angiocentric T/NK cell lymphoma of the nasal cavity with a view to establishing prognostic factors. Most patients were high or high intermediate clinical risk and had additional poor prognostic factors such as bulky disease, high levels of beta 2 microglobulin, advanced stage and multiple extranodal involvement. At 8 years, overall survival was 82%, 90% and 84% for low-intermediate, high-intermediate and high clinical, respectively. Disease free survival was very similar: 79%, 83% and 80%, respectively. Multivariate analysis did not identify any factor influencing overall survival and disease-free survival. There was no evidence that the international prognostic index (IPI) was applicable in these patients and it appears that angiocentric T/NK cell lymphoma is an independent prognostic factor itself.

Prognostic impact of absolute lymphocyte count/absolute monocyte count ratio and prognostic score in patients with nasal-type, extranodal natural killer/T-cell lymphoma

“…Previous studies explored the value of the IPI in ENKTL, but the results remain controversial. [6][7][8][9] In our study, 80.3% of all patients were in the low-risk IPI category, and this model failed to differentiate patients with different outcomes in the low-risk group. Moreover, the IPI did not discriminate well between patients in the high-intermediate and high-risk groups.…”

“…The International Prognostic Index (IPI) has been universally used for prognosis in many subtypes of NHL, especially in B-cell lymphoma, but its value in ENKTL remains debatable. [6][7][8][9] Lee et al 1 proposed the Korean Prognostic Index (KPI) and thought that it was better in predictive discrimination than the IPI model. However, the prognostic value of KPI in ENKTL is not generally accepted.…”

Primary nasal natural killer cell lymphoma: long-term treatment outcome and relationship with the International Prognostic Index

“…Rarely, the disease runs a fulminant course with disseminated organ involvement, sometimes accompanied by a leukemic phase, and is rapidly fatal. [1][2][3][4] Interestingly, these NK cell lymphomas show a geographic predilection, with patients reported mainly from Asian countries such as Hong Kong, [5][6][7][8][9] Japan, [10][11][12][13][14][15][16] and Korea, 17,18 and South American countries including Mexico, 19,20 Peru, 21 and Guatemala. 22 Some patients have been reported from other countries, although their ethnicity is usually poorly defined.…”

Treatment outcome of nasal NK-cell lymphoma: A report of 12 consecutively-diagnosed cases and a review of the literature.

“…NK/T-cell lymphoma of extranodal sites other than the nose is reported to be incurable and is almost always fatal6,7, while nasal NK/T-cell lymphoma has a more favorable outcome. Reported 5-year overall survival rates of nasal NK/T-cell lymphoma have ranged from 14 to 87%6, [8][9][10][11][12][13][14][15][16][17][18][19][20][21][22][23][24]. Approximately 90% of patients with nasal NK/Tcell lymphoma present with localized disease6, and the prognosis of patients with relapsed disease is extremely poor20.…”