Angiocrine signaling in sinusoidal homeostasis and liver diseases

Gao, Jinhang; Lan, Tian; Kostallari, Enis; Guo, Yangkun; Lai, Enjiang; Guillot, Adrien; Ding, Bisen; Tacke, Frank; Tang, Chengwei; Shah, Vijay H.

doi:10.1016/j.jhep.2024.05.014

Cited by 5 publications

(3 citation statements)

References 203 publications

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“…Under healthy conditions, LSECs help maintain hepatic homeostasis. During the progression of MASLD, LSECs become capillarized (termed capillarization) and exhibit an abnormal angiocrine signaling, partially leading to inflammation, lipid deposition, and liver fibrosis [ 121 ]. LSEC capillarization can precede MASLD and lead to the progression and perpetuation of MASH [ 120 ].…”

Section: Role Of Liver Cell Mitophagy In Masld and Liver Fibrosismentioning

confidence: 99%

“…In response to sustained liver injury, LSECs exhibit a switch from pro-regenerative to pro-fibrotic phenotype, with LSECs becoming capillarized. Pro-fibrotic LSECs contribute to dysregulated sinusoidal homeostasis, aberrant liver healing, and fibrosis progression [ 121 ]. As few studies focus on LSEC mitophagy in liver fibrosis, we speculate that LSEC mitophagy might be involved in the phenotypic switch of LSECs.…”

Section: Role Of Liver Cell Mitophagy In Masld and Liver Fibrosismentioning

confidence: 99%

“…Targeting LSEC mitophagy might be a potential modality for reversing LSEC capillarization. Due to the crucial role of LSECs in modulating cellular crosstalk via angiocrine signaling [ 121 ], LSEC mitophagy might also influence hepatocyte regeneration, HSC transformation, and macrophage infiltration and polarization.…”

Section: Role Of Liver Cell Mitophagy In Masld and Liver Fibrosismentioning

confidence: 99%

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Liver Cell Mitophagy in Metabolic Dysfunction-Associated Steatotic Liver Disease and Liver Fibrosis

Chen,

Jian,

Guo

et al. 2024

Antioxidants

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Metabolic dysfunction-associated steatotic liver disease (MASLD) affects approximately one-third of the global population. MASLD and its advanced-stage liver fibrosis and cirrhosis are the leading causes of liver failure and liver-related death worldwide. Mitochondria are crucial organelles in liver cells for energy generation and the oxidative metabolism of fatty acids and carbohydrates. Recently, mitochondrial dysfunction in liver cells has been shown to play a vital role in the pathogenesis of MASLD and liver fibrosis. Mitophagy, a selective form of autophagy, removes and recycles impaired mitochondria. Although significant advances have been made in understanding mitophagy in liver diseases, adequate summaries concerning the contribution of liver cell mitophagy to MASLD and liver fibrosis are lacking. This review will clarify the mechanism of liver cell mitophagy in the development of MASLD and liver fibrosis, including in hepatocytes, macrophages, hepatic stellate cells, and liver sinusoidal endothelial cells. In addition, therapeutic strategies or compounds related to hepatic mitophagy are also summarized. In conclusion, mitophagy-related therapeutic strategies or compounds might be translational for the clinical treatment of MASLD and liver fibrosis.

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Section: Role Of Liver Cell Mitophagy In Masld and Liver Fibrosismentioning

confidence: 99%

Section: Role Of Liver Cell Mitophagy In Masld and Liver Fibrosismentioning

confidence: 99%

Section: Role Of Liver Cell Mitophagy In Masld and Liver Fibrosismentioning

confidence: 99%

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Liver Cell Mitophagy in Metabolic Dysfunction-Associated Steatotic Liver Disease and Liver Fibrosis

Chen,

Jian,

Guo

et al. 2024

Antioxidants

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Blood flow‐induced angiocrine signals promote organ growth and regeneration

Follert,

Große‐Segerath,

Lammert

2024

BioEssays

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Recently, we identified myeloid‐derived growth factor (MYDGF) as a blood flow‐induced angiocrine signal that promotes human and mouse hepatocyte proliferation and survival. Here, we review literature reporting changes in blood flow after partial organ resection in the liver, lung, and kidney, and we describe the angiocrine signals released by endothelial cells (ECs) upon blood flow alterations in these organs. While hepatocyte growth factor (HGF) and MYDGF are important angiocrine signals for liver regeneration, by now, angiocrine signals have also been reported to stimulate hyperplasia and/or hypertrophy during the regeneration of lungs and kidneys. In addition, angiocrine signals play a critical role in tumor growth. Understanding the mechano‐elastic properties and flow‐mediated alterations in the organ‐specific microvasculature is crucial for therapeutic approaches to maintain organ health and initiate organ renewal.

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Gut microbiome and liver diseases

Xu,

Chen,

et al. 2024

Fundamental Research

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Angiocrine signaling in sinusoidal homeostasis and liver diseases

Cited by 5 publications

References 203 publications

Liver Cell Mitophagy in Metabolic Dysfunction-Associated Steatotic Liver Disease and Liver Fibrosis

Liver Cell Mitophagy in Metabolic Dysfunction-Associated Steatotic Liver Disease and Liver Fibrosis

Blood flow‐induced angiocrine signals promote organ growth and regeneration

Gut microbiome and liver diseases

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