2006
DOI: 10.1111/j.1524-4725.2005.31166
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Angioedema Acute Hypersensitivity Reaction to Injectable Hyaluronic Acid

Abstract: Although injectable hyaluronic acid has a high safety profile, this reaction is dramatic. Treatments and potential mechanisms are discussed.

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Cited by 48 publications
(45 citation statements)
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“…[86][87][88][89] Severe systemic hypersensitivity reactions secondary to injections of hyaluronic acid fillers are even more rare than local side effects. 90,91 However, nonallergic local side effects at the sites of injections are frequent, including pain, bruising, and transient edema, but they disappear in a few days and usually do not need any treatment. 92 It has been suggested that the reason hyaluronic acid fillers cause more swelling and bruising than collagen fillers is the anticoagulant effect of hyaluronic acid, which has a structural similarity to heparin.…”
Section: Bovine Collagen Key Pointsmentioning
confidence: 99%
“…[86][87][88][89] Severe systemic hypersensitivity reactions secondary to injections of hyaluronic acid fillers are even more rare than local side effects. 90,91 However, nonallergic local side effects at the sites of injections are frequent, including pain, bruising, and transient edema, but they disappear in a few days and usually do not need any treatment. 92 It has been suggested that the reason hyaluronic acid fillers cause more swelling and bruising than collagen fillers is the anticoagulant effect of hyaluronic acid, which has a structural similarity to heparin.…”
Section: Bovine Collagen Key Pointsmentioning
confidence: 99%
“…2,4 According to some reports, the protein load of Restylane is approximately 12 to 17 ng/mL. 6,7 On the other hand, NASHA uses cross-linking compounds, mainly butanediol diglicidileter, which is not NASHA specific. Could this cross-linker play a role in the adverse effects related to NASHA compounds?…”
Section: Discussionmentioning
confidence: 99%
“…Angioedema can be related to the material or to host factors; true immune-mediated angioedema is rare, estimated as less than 1 to 5 in 10,000, and thought to be related to protein contaminants present in the material. 66,67 HA-related angioedema can be treated with hyaluronidase or removal of the HA derivative.…”
Section: Early Onset Complicationsmentioning
confidence: 99%