Angioedema: Etiology, Pathophysiology, Current and Emerging Therapies

Lewis, Lawrence M.

doi:10.1016/j.jemermed.2013.03.045

Cited by 54 publications

(67 citation statements)

References 51 publications

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“…9,12 Symptom severity and time from symptom onset to seeking medical assistance varies between individuals, but most patients present to the ED 4 to 6 hours after symptom onset. 3 A diagnosis of ACEIA is made primarily by a history of ACEI use, the classic signs and symptoms of nonallergic angioedema, 13 and, typically, a limited response to standard "allergic" treatment, such as histamine-1 and -2 receptor antagonists, corticosteroids, and in some cases, epinephrine. 5,13,14 Editor's Capsule Summary…”

Section: Introductionmentioning

confidence: 99%

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Ecallantide for the Acute Treatment of Angiotensin-Converting Enzyme Inhibitor–Induced Angioedema: A Multicenter, Randomized, Controlled Trial

Lewis¹,

Graffeo²,

Crosley³

et al. 2015

Annals of Emergency Medicine

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Section: Introductionmentioning

confidence: 99%

“…3 A diagnosis of ACEIA is made primarily by a history of ACEI use, the classic signs and symptoms of nonallergic angioedema, 13 and, typically, a limited response to standard "allergic" treatment, such as histamine-1 and -2 receptor antagonists, corticosteroids, and in some cases, epinephrine. 5,13,14 Editor's Capsule Summary…”

Section: Introductionmentioning

confidence: 99%

Ecallantide for the Acute Treatment of Angiotensin-Converting Enzyme Inhibitor–Induced Angioedema: A Multicenter, Randomized, Controlled Trial

Lewis¹,

Graffeo²,

Crosley³

et al. 2015

Annals of Emergency Medicine

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“…This is a result of the offending agent binding directly to mast cells and inducing their degranulation with release of inflammatory mediators, particularly histamine, [3] leading to angio-oedema and urticaria. [9] It does not require IgE mediation [3,10] and no prior sensitisation is needed.…”

Section: This Open Access Article Is Distributed Under Creative Commomentioning

confidence: 99%

Angio-oedema associated with colistin

et al. 2016

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“…En la tabla 1 se resume la frecuencia mundial de las principales enfermedades alérgicas, según datos recopilados de varias fuentes (1,6,(20)(21)(22)(23)(24)(25)(26).…”

Section: Epidemiologíaunclassified

Allergic reactions: key aspects and new perspectives

Restrepo¹

2016

An. Fac. Cienc. Méd. (Asunción)

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RESUMENLas reacciones alérgicas son una respuesta inmune exacerbada a un alérgeno en un individuo atópico. En éstas, influyen dos factores el genético y el ambiental. Con base en lo anterior, la Organización Mundial de Alergia determinó como enfermedades alérgicas al asma, rinitis, sinusitis, conjuntivitis, anafilaxia, alergia a medicamentos, alimentos, animales, insectos y hongos, eczema, urticaria y angioedema; las cuales han aumentado en el último tiempo, convirtiéndose en un problema de salud pública con repercusiones económicas exorbitantes. Asimismo, se han dado avances tanto en el diagnóstico, cuyos pilares siguen siendo la historia clínica, la medición de inmunoglobulina E específica y pruebas cutáneas; el tratamiento y las bases genéticas, que cada vez son más relevantes en el manejo clínico de estas entidades.Palabras clave: Alérgeno, ambiente, atopia, genética, reacción alérgica. ABSTRACTAllergic reactions are an exaggerated immune response to an allergen in atopic individuals. In these, two factors influence: the genetic and environmental. Therefore, the World Allergy Organization determined as allergic diseases asthma, rhinitis, sinusitis, conjunctivitis, anaphylaxis, drug allergy, foods, animals, insects and fungi, eczema, urticaria and angioedema; which have increased in recent times, becoming a public health problem with an exorbitant economic burden. Also, there have been advances in diagnosis, whose pillars are still medical history, measurement of specific immunoglobulin E and skin tests; treatment and genetic basis, which are increasingly important in the clinical management of these entities.Key Words: Allergen, environment, atopy, genetic, allergic reaction. INTRODUCCIONEl término reacción alérgica o hipersensibilidad se refiere a una respuesta inmune exacerbada o inapropiada del individuo predispuesto genéticamente o atópico, que se da en presencia de un alérgeno específico, definido como una molécula proteica vegetal, animal o fúngica que induce la

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Angioedema: Etiology, Pathophysiology, Current and Emerging Therapies

Cited by 54 publications

References 51 publications

Ecallantide for the Acute Treatment of Angiotensin-Converting Enzyme Inhibitor–Induced Angioedema: A Multicenter, Randomized, Controlled Trial

Ecallantide for the Acute Treatment of Angiotensin-Converting Enzyme Inhibitor–Induced Angioedema: A Multicenter, Randomized, Controlled Trial

Angio-oedema associated with colistin

Allergic reactions: key aspects and new perspectives

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