Angioedema in the emergency department: A presentation of lymphoma

Abstract

A 58‐year‐old woman presented to emergency departments on several occasions with episodic angioedema. Lymphoplasmacytic lymphoma with an IgM paraprotein (Waldenstrom’s macroglobulinemia) was eventually diagnosed 14 months later in association with acquired C1 esterase inhibitor deficiency. Resolution of the angioedema and C1 esterase inhibitor deficiency was achieved with danazol and treatment of the underlying lymphoma.

Onset of angioedema following a viper bite: different options for diagnostic procedure in an emergency department

“…Moreover, monoclonal gammopathies, lymphoproliferative syndromes, autoimmune diseases, neoplasms and infections have been reported as diseases associated with acquired angioedema (3,12). Although not frequently reported, lymphoproliferative disorders of mature B-lymphocytes expressing IgM kappa or lambda are the prominent disorders underlying an acquired angioedema (3,(13)(14)(15), and the latter is an important, potentially life-threatening complication of lymphoma. It is also important a prompt suspicion and recognition of these conditions, because an appropriate treatment of the associated disease could resolve angioedema in some patients (3).…”