Angiogenese und Dichte dendritischer Zellen korrelieren nicht mit der metachronen Fernmetastasierung beim kurativ operierten Rectumcarcinom

Günther, Klaus; Radkow, Tanja; Reymond, Marc A.; Pflüger, Rafael; Dimmler, Arno; Hohenberger, Werner; Papadopoulos, T.

doi:10.1007/s001040170053

Cited by 1 publication

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“…According to the consensus of the NIH (National Institute of Health), patients with UICC stage I rectal cancer (pT1/2, pN0) are not enrolled to adjuvant radiochemotherapy, whereas patients with UICC stage II rectal cancer (pT3/4, pN0) undergo adjuvant radiochemotherapy [20]. However, reflecting our collective, 24.2% (8/33) of UICC stage II develop distant metastases (without local recurrence) after curative resection, which means that -from the theoretical aspectradiochemotherapy means 'over-therapy' in 75.8% of patients; this is also explained by other authors [21]. Consequently, identification of prognostic factors to predict individual outcome, to select appropriate adjuvant treatment and follow-up options, and, finally, to analyze and compare treatment results is a crucial issue [22].…”

Section: Discussionmentioning

confidence: 37%

Prognostic Significance of p21 and p27 Protein, Apoptosis, Clinical and Histologic Factors in Rectal Cancer without Lymph Node Metastases

Schwandner¹,

Bruch²,

Broll

2002

Eur Surg Res

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The aim of this study was to evaluate the prognostic role of clinical and histopathologic factors, cell-cycle regulator proteins (p21^Waf1/Cip1, p27^Kip1), and apoptotic index in lymph node-negative rectal cancer. Formalin-fixed, paraffin-embedded tissue samples of 97 rectal carcinomas (UICC stages I and II) resected curatively within five years were used. Immunohistochemical analysis of protein expression was performed by monoclonal antibodies: p21 (clone SX118), p27 (clone SX53G8). Apoptosis was assessed by the TUNEL method. Clinical, surgical, histopathologic, and follow-up data were prospectively recorded in a computerized registry. To assess prognostic significance (end points: metachronous distant metastases, 5-year disease-free and overall survival), statistics included univariate and multivariate analysis (p < 0.05 statistically significant). Of the 97 rectal carcinomas without lymph node metastases, 46.4% (45/97) were p21-positive, 49.5% were p27-positive (48/97), whereas 27.8% (27/97) showed a high apoptotic index. Within a median follow-up of 54 months, 4 patients developed local recurrence (4.1%). Distant metastases occurred in 12 patients (12.4%). Univariate analysis showed that gender, UICC stage, p21 and p27 were significantly associated with the incidence of distant metastases (p < 0.05). UICC stage and p21 were the only factors to be significantly related to 5-year disease-free survival by univariate analysis (p < 0.05). Only UICC stage was significantly related to 5-year overall survival (p < 0.05). The apoptotic index was correlated neither to recurrence nor to survival (p > 0.05). Multivariate analysis demonstrated that gender, UICC stage and p21 were independently related to the incidence of distant metastases; however, UICC stage was the only independent factor predictive of 5-year disease-free survival and overall survival (p < 0.05).

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Section: Discussionmentioning

confidence: 37%

Prognostic Significance of p21 and p27 Protein, Apoptosis, Clinical and Histologic Factors in Rectal Cancer without Lymph Node Metastases

Schwandner¹,

Bruch²,

Broll

2002

Eur Surg Res

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Angiogenese und Dichte dendritischer Zellen korrelieren nicht mit der metachronen Fernmetastasierung beim kurativ operierten Rectumcarcinom

Abstract: Angiogenesis and density of dendritic cells in rectal cancer are not prognostic factors for metachronous distant metastasis and, therefore, cannot serve as selection parameters for adjuvant therapy.

Cited by 1 publication

References 31 publications

Prognostic Significance of p21 and p27 Protein, Apoptosis, Clinical and Histologic Factors in Rectal Cancer without Lymph Node Metastases

Prognostic Significance of p21 and p27 Protein, Apoptosis, Clinical and Histologic Factors in Rectal Cancer without Lymph Node Metastases

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