Angiogenesis — a self-adapting principle in hypoxia

Cerebrovascular adaptations to cocaine-induced transient ischemic attacks in the rodent brain

“…This would suggest that similar strategies might be beneficial to help enhance brain recovery after cocaine-induced ischemia (40,41). Thus, our findings are clinically relevant, which suggests that enhancing angiogenesis might prevent strokes in cocaine abusers and improve recovery in cocaine abusers suffering from strokes or TIA presentations.…”

Prognostic Impact of HIF-1α Expression in Patients with Definitive Radiotherapy for Cervical Cancer

“…Moreover, ischemia in the brain, heart or lung was associated with upregulation of this angiogenic factor [4]. These results may indicate that both HIF-1α and VEGF are important markers of hypoxia [28]. However, the prognostic value of relevant tumor hypoxia expression in clinically applicable methods or as an endogenous marker for assessment is controversial in cervical cancers [29,38].…”

Tubular sprouting as a mode of vascular formation in a colonial ascidian (tunicata)

“…VEGF is a critical inducer of proliferation, migration, sprouting, and tube formation in tissues during angiogenesis (Tammela et al, 2005). Its binding sites VEGFR-1/Flt-1 and VEGFR-2/Flk-1 work in a competitive way to regulate the VEGF signal in response to variations in physiological conditions (Ferrara et al, 2003;Kearney et al, 2004;Roberts et al, 2004;Ferrara, 2005;Marti, 2005;Nanka et al, 2006).…”