Angiogenesis and Developmental Expression of Vascular Endothelial Growth Factor in Rat Lingual Papillae

Hirao, Tomoko; Saga, Tsuneo; Kusukawa, Jingo; Yamaki, Koh-Ichi

doi:10.2739/kurumemedj.54.9

Cited by 8 publications

(11 citation statements)

References 37 publications

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“…The giant conical papillae was observed in the limited crescent region of the intermolar eminence [22]. The branched papillae was observed in the posterior region between the giant conical papillae region anteriorly and the circumvallate papilla posteriorly with tip protrusions further branched into several twigs [22,24]. The above findings about localizations of the giant conical and branched papillae coincide well with findings of the conical and branched FiP described in the present study.…”

Section: Development Of the Tongue Papillae In The Postnatal Periodsupporting

confidence: 91%

“…In rats, the simple conical papillae, giant conical papillae, and branched papillae are classified and known to have different localization [24,25]. The simple conical FiP is located in the anterior tongue and its body tilted backward [22]. Although its shape was described as conical, it is conceivably of the same type as the round tip FiP of the anterior part in the present study.…”

Section: Development Of the Tongue Papillae In The Postnatal Periodmentioning

confidence: 52%

“…Although its shape was described as conical, it is conceivably of the same type as the round tip FiP of the anterior part in the present study. The giant conical papillae was observed in the limited crescent region of the intermolar eminence [22]. The branched papillae was observed in the posterior region between the giant conical papillae region anteriorly and the circumvallate papilla posteriorly with tip protrusions further branched into several twigs [22,24].…”

Section: Development Of the Tongue Papillae In The Postnatal Periodmentioning

confidence: 99%

“…The intermolar eminence is visible at the mid-portion of the rat tongue body and enables us to subdivide it into three parts: anterior, middle (intermolar eminence), and posterior [22].…”

Section: Development Of the Tongue Papillae In The Postnatal Periodmentioning

confidence: 99%

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2017

Cent Asian J Med Sci

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Objectives:To clarify the morphology of the tongue papillae formation and the metabolic characteristics along the papillae distribution in rats. Methods: The experiment was designed as a cross-sectional study and included; a scanning electron and light microscopic examination, connective tissue core analysis, and an enzyme activity test on rat tongue samples of the embryonic (n = 60) and postnatal (n = 12) periods. Results: The primordium of fungiform papillae (FuP) was already formed on embryonic day 15 (E15), and filiform papillae (FiP) was formed on E17. In the postnatal period, the middle and posterior parts of the tongue quickly developed toward the anterior part of the oral cavity. Three types of FiP were found: round, conical and branched. According to the enzyme activity test, all energy, lipid, protein and sugar metabolic enzymes showed significant differences along the tongue parts. Conclusion: No positional difference was found in the morphology of rat tongue papillae during the embryonic period. During the postnatal period, the morphology and enzyme activities of the tongue mucosa displayed differences expressing tongue development and its functional characteristics among the described tongue parts-listed above.

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Section: Development Of the Tongue Papillae In The Postnatal Periodsupporting

confidence: 91%

Section: Development Of the Tongue Papillae In The Postnatal Periodmentioning

confidence: 52%

Section: Development Of the Tongue Papillae In The Postnatal Periodmentioning

confidence: 99%

“…The intermolar eminence is visible at the mid-portion of the rat tongue body and enables us to subdivide it into three parts: anterior, middle (intermolar eminence), and posterior [22].…”

Section: Development Of the Tongue Papillae In The Postnatal Periodmentioning

confidence: 99%

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2017

Cent Asian J Med Sci

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“…A modified ink injection technique was used to visualize the intestinal microvasculature [19, 20]. Following heparin-saline perfusion, animals were perfused with the pretreated warm (37°C) India ink mixture at a constant infusion pre ssure of 100 ± 5 mmHg.…”

Section: Methodsmentioning

confidence: 99%

HB-EGF Improves Intestinal Microcirculation after Hemorrhagic Shock

Zhang

Radulescu

Chen

et al. 2011

Journal of Surgical Research

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Regional regulation of Filiform tongue papillae development by Ikkα/Irf6

Kawasaki

Oommen

et al. 2016

Developmental Dynamics

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Background: Non-gustatory filiform papillae play critical roles in helping to grip food, drawing food to the esophagus, cleaning the mouth, and spreading saliva. The molecular mechanisms of filiform tongue papillae development however are not fully understood. Results: We found Ikka and Irf6 expression in developing tongue epithelium, and describe here specific tongue abnormalities in mice with mutation of these genes, indicating a role for Ikka and Irf6 in filiform papillae development. Ikka and Irf6 mutant tongues showed ectopic vertical epithelium at the midline, while lateral sides of mutant tongues adhered to the oral mucosa. Both the ectopic median vertical epithelium and adhered epithelium exhibited the presence of filiform tongue papillae, whereas epithelium between the median vertical epithelium and adhered tongue showed a loss of filiform tongue papillae. Timing of filiform papillae development was found to be slightly different between the midline and lateral regions of the wild-type tongue. Conclusions: Filiform papillae thus develop through distinct molecular mechanisms between the regions of tongue dorsum in the medio-lateral axis, with some filiform papillae developing under the control of Ikka and Irf6. Developmental Dynamics 245:937-946,

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Angiogenesis and Developmental Expression of Vascular Endothelial Growth Factor in Rat Lingual Papillae

Cited by 8 publications

References 37 publications

Untitled

Untitled

HB-EGF Improves Intestinal Microcirculation after Hemorrhagic Shock

Regional regulation of Filiform tongue papillae development by Ikkα/Irf6

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