Angiogenesis and oxidative stress: Common mechanisms linking psoriasis with atherosclerosis

Armstrong, April W.; Voyles, Stephanie V.; Armstrong, Ehrin J.; Fuller, Erin N.; Rutledge, John C.

doi:10.1016/j.jdermsci.2011.04.007

Cited by 146 publications

(138 citation statements)

References 107 publications

(157 reference statements)

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Section: Angiogenic and Oxidative Processes In Psoriasis And Atheroscmentioning

confidence: 99%

“…16 Psoriatic lesions consist of dilated, tortuous, and prolific capillaries in the upper one-third of the dermis. 16 Microvascular changes precede keratinocyte hyperplasia and the appearance of any psoriatic plaques. 16,61 Pathologic angiogenesis is triggered by hypoxia or injury due to epidermal disruption in psoriasis and endothelial dysfunction in atherosclerosis.…”

Section: Angiogenic and Oxidative Processes In Psoriasis And Atheroscmentioning

confidence: 99%

“…The understanding of the mechanistic basis for the observed epidemiologic association between psoriasis and CVD has evolved. 15,16 In this review, we first discuss pivotal studies that investigated the relationship between psoriasis and CV factors and outcomes. While numerous epidemiologic studies have examined the association of psoriasis and CVD, the focus of this article is not to exhaustively present all studies, but to discuss findings from selected, large, population-based studies from well-characterized populations.…”

Section: Introductionmentioning

confidence: 99%

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Psoriasis and cardiovascular disease: epidemiology, mechanisms, and clinical implications

Pearson¹,

Armstrong

2012

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Psoriasis is a systemic inflammatory disorder, which has been reported to be associated with adverse cardiovascular (CV) risks. CV comorbidities, such as diabetes, dyslipidemia, hypertension, and obesity appear to be increased in psoriasis patients compared with the general population. Psoriasis may contribute independently to adverse cardiac outcomes after accounting for traditional CV risk factors. In this article, it was aimed to summarize large population studies that examine the relationship between psoriasis and CV risk factors and major adverse cardiac outcomes, and highlight proposed mechanisms for the observed epidemiologic link. Specifically, large population-based studies with over 1000 total subjects from 1975 to September 2008 in the English literature are highlighted. The relevant search terms in the Ovid Medline database were applied. The majority of the studies presented evidence for an increased incidence of CV risk factors and an increased risk for major adverse cardiac outcomes in patients with severe psoriasis. The increased risk in severe psoriasis necessitates regular screening for other comorbidities. Current guidelines for screening CV risk factors among psoriasis patients are discussed. Also reviewed is the scarce literature in therapeutic strategies to reduce CV risk factors and major adverse cardiac outcomes in psoriasis patients. Specifically, an emerging area of research on the effects of biologic agents on CV risk factors and CV adverse outcomes in psoriasis is discussed.

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Section: Angiogenic and Oxidative Processes In Psoriasis And Atheroscmentioning

confidence: 99%

Section: Angiogenic and Oxidative Processes In Psoriasis And Atheroscmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Psoriasis and cardiovascular disease: epidemiology, mechanisms, and clinical implications

Pearson¹,

Armstrong

2012

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“…25 Furthermore, data suggest that patients with severe psoriasis have higher odds for dyslipidemia compared to patients with mild forms of the disease. 26 A meta-analysis of 25 observational studies of almost 150 000 patients with psoriasis and more than half a million patients without psoriasis revealed an association between psoriasis and either current smoking (OR: 1.78; 95% CI: 1.52-2.06) or former smoking (OR: 1.62; 95% CI: 1.33-1.99). 27 In addition, an association between smoking and incidence of psoriasis was observed, which was dependent on smoking duration and intensity.…”

mentioning

confidence: 99%

“…38 Atherosclerosis is typically characterized by systemic inflammation, cytokine dysregulation, and invasion of inflammatory cells as well, contributing in the development of atherosclerotic plaques. 26 Furthermore, T helper 1 and 17, regulatory T cells and natural killer T cells have been implicated in the pathogenetic pathways of both diseases. [39][40][41] Among other inflammatory molecules, interleukins 2,6,7,8,12,15,17,18,20, and 23; tumor necrosis factor a; and interferon g participate in the expression of other chemokines and growth factors resulting in stimulation of inflammatory cells, endothelial dysfunction, and vascular smooth muscle proliferation that are all implicated in the pathophysiology of both psoriasis and atherosclerosis.…”

mentioning

confidence: 99%