Angiogenesis and Vascular Functions in Modulation of Obesity, Adipose Metabolism, and Insulin Sensitivity

Cao, Yihai

doi:10.1016/j.cmet.2013.08.008

Cited by 269 publications

(279 citation statements)

References 89 publications

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“…The closed structural relationship between adipocytes and vasculature facilitates constant and immediate responses to various conditions to maintain metabolic homeostasis. In addition to its basic roles, the adipose vasculature has important roles in providing hormones, growth factors, inflammation-related cytokines, and stem cells to adipose tissues (Nishimura et al, 2009;Christiaens and Lijnen, 2010;Cao, 2013). Our findings indicate that the role of the growing vasculature as an adipose niche applies also to the growth of PPAs as a cluster during embryogenesis.…”

Section: Discussionmentioning

confidence: 63%

Perilipin+ embryonic preadipocytes actively proliferate along growing vasculatures for adipose expansion

et al. 2015

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Despite the growing interest in adipose tissue as a therapeutic target of metabolic diseases, the identity of adipocyte precursor cells (preadipocytes) and the formation of adipose tissue during embryonic development are still poorly understood. Here, we clarified the identity and dynamic processes of preadipocytes in mouse white adipose tissue during embryogenesis through direct examination, lineage tracing and culture systems. Surprisingly, we found that lipid-lacking but perilipin + or adiponectin + proliferating preadipocytes started to emerge at embryonic day 16.5, and these cells underwent active proliferation until birth. Moreover, these preadipocytes resided as clusters and were distributed along growing adipose vasculatures. Importantly, the embryonic preadipocytes exhibited considerable coexpression of stem cell markers, such as CD24, CD29 and PDGFRα, and a small portion of preadipocytes were derived from PDGFRβ + mural cells, in contrast to the adult preadipocytes present in the stromal vascular fraction. Further analyses with in vitro and ex vivo culture systems revealed a stepwise but dynamic regulation of preadipocyte formation and differentiation during prenatal adipogenesis. To conclude, we unraveled the identity and characteristics of embryonic preadipocytes, which are crucial for the formation and expansion of adipose tissue during embryogenesis.

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Section: Discussionmentioning

confidence: 63%

Perilipin+ embryonic preadipocytes actively proliferate along growing vasculatures for adipose expansion

et al. 2015

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“…This figure was created using Servier Medical Art templates, which are licensed under a Creative Commons Attribution 3.0 Unported License; https://smart.servier.com. , 2013;Ryan and Nicklas, 1999). Similarly, the appearance of adipocytes in the pancreas has been observed in obese subjects (Lee et al, 2010b;Pinnick et al, 2008).…”

Section: Beyond Vat and Sat -Other White Adipose Tissue Depotsmentioning

confidence: 74%

“…3). The exact molecular mechanisms regulating neovascularization in adipose tissue have been extensively reviewed (Cao, 2007(Cao, , 2013Corvera and Gealekman, 2014); however, the role played by the ECM and cellular receptors, such as integrins, in the differential function and disease association of adipose tissue depots is less well understood.…”

Section: Remodeling Of the Ecm Is A Prerequisite For Adipose Tissue Ementioning

confidence: 99%

Heterogeneity of adipose tissue in development and metabolic function

Schoettl

Fischer

Ussar

2018

Journal of Experimental Biology

177

139

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Adipose tissue is a central metabolic organ. Unlike other organs, adipose tissue is compartmentalized into individual depots and distributed throughout the body. These different adipose depots show major functional differences and risk associations for developing metabolic syndrome. Recent advances in lineage tracing demonstrate that individual adipose depots are composed of adipocytes that are derived from distinct precursor populations, giving rise to different populations of energy-storing white adipocytes. Moreover, distinct lineages of energy-dissipating brown and beige adipocytes exist in discrete depots or within white adipose tissue depots. In this Review, we discuss developmental and functional heterogeneity, as well as sexual dimorphism, between and within individual adipose tissue depots. We highlight current data relating to the differences between subcutaneous and visceral white adipose tissue in the development of metabolic dysfunction, with special emphasis on adipose tissue expansion and remodeling of the extracellular matrix. Moreover, we provide a detailed overview of adipose tissue development as well as the consensus and controversies relating to adult adipocyte precursor populations.

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“…It is believed that these vasculature-related pericyte functions could possibly impede tumor invasion and metastasis. Recent studies show that pericytes retain progenitor cell properties and can differentiate into other cells, including adipocytes, chondrocytes, osteoblasts, phagocytes, granulocytes, and skeletal muscle (14)(15)(16)(17)(18). Under pathological conditions, pericytes may differentiate into myofibroblasts, contributing to kidney fibrosis (19,20).…”

mentioning

confidence: 99%

Pericyte–fibroblast transition promotes tumor growth and metastasis

Hosaka

Yang

Seki

et al. 2016

Proc. Natl. Acad. Sci. U.S.A.

Self Cite

283

236

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Vascular pericytes, an important cellular component in the tumor microenvironment, are often associated with tumor vasculatures, and their functions in cancer invasion and metastasis are poorly understood. Here we show that PDGF-BB induces pericyte-fibroblast transition (PFT), which significantly contributes to tumor invasion and metastasis. Gain-and loss-of-function experiments demonstrate that PDGF-BB-PDGFRβ signaling promotes PFT both in vitro and in in vivo tumors. Genome-wide expression analysis indicates that PDGF-BB-activated pericytes acquire mesenchymal progenitor features. Pharmacological inhibition and genetic deletion of PDGFRβ ablate the PDGF-BB-induced PFT. Genetic tracing of pericytes with two independent mouse strains, TN-AP-CreERT2:R26R-tdTomato and NG2-CreERT2:R26R-tdTomato, shows that PFT cells gain stromal fibroblast and myofibroblast markers in tumors. Importantly, coimplantation of PFT cells with less-invasive tumor cells in mice markedly promotes tumor dissemination and invasion, leading to an increased number of circulating tumor cells and metastasis. Our findings reveal a mechanism of vascular pericytes in PDGF-BB-promoted cancer invasion and metastasis by inducing PFT, and thus targeting PFT may offer a new treatment option of cancer metastasis.pericyte | PDGF | fibroblast | metastasis | mesenchymal cell

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Angiogenesis and Vascular Functions in Modulation of Obesity, Adipose Metabolism, and Insulin Sensitivity

Cited by 269 publications

References 89 publications

Perilipin+ embryonic preadipocytes actively proliferate along growing vasculatures for adipose expansion

Perilipin+ embryonic preadipocytes actively proliferate along growing vasculatures for adipose expansion

Heterogeneity of adipose tissue in development and metabolic function

Pericyte–fibroblast transition promotes tumor growth and metastasis

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