Angiogenesis, Computational Modeling Perspective

Qutub, Amina A.; Popel, Aleksander S.

doi:10.1007/978-3-540-70529-1_162

Cited by 2 publications

(2 citation statements)

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“…The limitations of our model affect the number of sprouting angiogenesis processes that we can reproduce and the extent to which we can simulate them. Some of the processes that are beyond the scope of our model have been studied using other previously published models (Peirce, 2008 ; Qutub et al, 2009 ; Scianna et al, 2013 ; Logsdon et al, 2014 ; Heck et al, 2015 ; Qutub and Popel, 2015 ) while other processes offer opportunities for further research as specified in the following paragraphs.…”

Section: Discussionmentioning

confidence: 99%

“…Due to the enormous biological and medical importance of angiogenesis, many computational and mathematical models have been proposed to explore the molecular mechanism involved in angiogenesis control (Peirce, 2008 ; Qutub et al, 2009 ; Scianna et al, 2013 ; Logsdon et al, 2014 ; Heck et al, 2015 ; Qutub and Popel, 2015 ). Some of the relevant previous models are the following: (a) A computational model exploring the relationship between hemodynamics and angiogenesis in 2D (Gödde and Kurz, 2001 ).…”

Section: Introductionmentioning

confidence: 99%

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A Network Model to Explore the Effect of the Micro-environment on Endothelial Cell Behavior during Angiogenesis

et al. 2017

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Angiogenesis is an important adaptation mechanism of the blood vessels to the changing requirements of the body during development, aging, and wound healing. Angiogenesis allows existing blood vessels to form new connections or to reabsorb existing ones. Blood vessels are composed of a layer of endothelial cells (ECs) covered by one or more layers of mural cells (smooth muscle cells or pericytes). We constructed a computational Boolean model of the molecular regulatory network involved in the control of angiogenesis. Our model includes the ANG/TIE, HIF, AMPK/mTOR, VEGF, IGF, FGF, PLCγ/Calcium, PI3K/AKT, NO, NOTCH, and WNT signaling pathways, as well as the mechanosensory components of the cytoskeleton. The dynamical behavior of our model recovers the patterns of molecular activation observed in Phalanx, Tip, and Stalk ECs. Furthermore, our model is able to describe the modulation of EC behavior due to extracellular micro-environments, as well as the effect due to loss- and gain-of-function mutations. These properties make our model a suitable platform for the understanding of the molecular mechanisms underlying some pathologies. For example, it is possible to follow the changes in the activation patterns caused by mutations that promote Tip EC behavior and inhibit Phalanx EC behavior, that lead to the conditions associated with retinal vascular disorders and tumor vascularization. Moreover, the model describes how mutations that promote Phalanx EC behavior are associated with the development of arteriovenous and venous malformations. These results suggest that the network model that we propose has the potential to be used in the study of how the modulation of the EC extracellular micro-environment may improve the outcome of vascular disease treatments.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

A Network Model to Explore the Effect of the Micro-environment on Endothelial Cell Behavior during Angiogenesis

et al. 2017

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Design Approaches to Myocardial and Vascular Tissue Engineering

Akintewe

Roberts

Rim

et al. 2017

Annu. Rev. Biomed. Eng.

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Engineered tissues represent an increasingly promising therapeutic approach for correcting structural defects and promoting tissue regeneration in cardiovascular diseases. One of the challenges associated with this approach has been the necessity for the replacement tissue to promote sufficient vascularization to maintain functionality after implantation. This review highlights a number of promising prevascularization design approaches for introducing vasculature into engineered tissues. Although we focus on encouraging blood vessel formation within myocardial implants, we also discuss techniques developed for other tissues that could eventually become relevant to engineered cardiac tissues. Because the ultimate solution to engineered tissue vascularization will require collaboration between wide-ranging disciplines such as developmental biology, tissue engineering, and computational modeling, we explore contributions from each field.

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Angiogenesis, Computational Modeling Perspective

Cited by 2 publications

References 100 publications

A Network Model to Explore the Effect of the Micro-environment on Endothelial Cell Behavior during Angiogenesis

A Network Model to Explore the Effect of the Micro-environment on Endothelial Cell Behavior during Angiogenesis

Design Approaches to Myocardial and Vascular Tissue Engineering

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