Angiogenesis in Cutaneous Lesions of Leprosy

Bhandarkar, Sulochana S.; Cohen, Cynthia; Kuruvila, Maria; Rea, Thomas H.; MacKelfresh, Jamie; Lee, Delphine J.; Modlin, Robert L.; Arbiser, Jack L.

doi:10.1001/archderm.143.12.1527

Cited by 11 publications

(10 citation statements)

References 18 publications

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“…For example, bartonella infection induces rac activation and ang-2 production to mimic a hemangioma (66,67). Increased angiogenesis is seen in lepromatous leprosy, in which an ineffective immune response, due in part to loss of interleukin-12 and other angiogenesis inhibitors, allows engorgement of cells into tumor-like masses (91). We have recently shown that lepromatous leprosy is highly angiogenic, and that administration of angiogenesis inhibitors may shorten the duration of therapy needed to treat mycobacterial infections, such as leprosy and tuberculosis.…”

Section: Angiogenesis and Infectionmentioning

confidence: 99%

Application of Angiogenesis to Clinical Dermatology

Fried

Arbiser

2008

Advances in Dermatology

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Section: Angiogenesis and Infectionmentioning

confidence: 99%

Application of Angiogenesis to Clinical Dermatology

Fried

Arbiser

2008

Advances in Dermatology

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“…We demonstrated that lepromatous leprosy had a higher microvessel count than tuberculoid leprosy. In the current study of cutaneous Mycobacterium tuberculosis infection, we found that TBVC had an elevated microvessel count compared to LV, despite LV having a clinically more aggressive course (3). This difference suggests that Mycobacterium tuberculosis is controlled in the skin through a different mechanism than Mycobacterium leprae.…”

Section: Introductionmentioning

confidence: 61%

“…Previously, we examined angiogenesis in differing stages of leprosy, caused by a Mycobacterium (3). We demonstrated that lepromatous leprosy had a higher microvessel count than tuberculoid leprosy.…”

Section: Introductionmentioning

confidence: 99%

Tuberculosis verrucosa cutis lesions exhibit a greater microvessel count than lupus vulgaris lesions

Bhandarkar

Lanka

et al. 2016

Experimental Dermatology

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“…Bhandarkar et al8 studied angiogenesis in 32 leprosy patients using CD31 as a marker for microvessel density. The MVD of lepromatous leprosy lesions was (44.0 ± 9.8 v/HPF).…”

Section: Discussionmentioning

confidence: 99%

Inhibition of angiogenesis as a new therapeutic target in the treatment of lepromatous leprosy

El‐Khalawany

D²,

M³

et al. 2011

CCID

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BackgroundAngiogenesis was suggested to have a significant role in the pathogenesis of leprosy. However, the benefit of inhibiting angiogenesis in lepromatous leprosy patients has not previously been studied. The purpose of this study was to evaluate angiogenesis in leprosy patients before and after treatment with multidrug therapy (MDT) with and without minocycline.MethodsA total of 40 patients with lepromatous leprosy were enrolled in this study. They were categorized into two equal groups (A and B), each formed of 20 patients. Group A received World Health Organization MDT, and Group B received MDT combined with minocycline, which has a known antiangiogenic effect. Microvascular density (MVD) in dermal granuloma was evaluated in both groups by immunostaining with CD31 and CD34 markers before and after 6 months of treatment.ResultsWith CD31 immunostaining, the mean MVD in Group A significantly decreased from 39.1 ± 3.1 vessels (v)/high power field (HPF) to 16.5 ± 2.7 v/HPF, and in Group B it significantly decreased from 38.3 ± 2.5 v/HPF to 7.6 ± 1.9 v/HPF. CD34 immunostaining also showed a significant decrease of MVD from 42.2 ± 3.1 v/HPF to 18.8 ± 2.4 v/HPF in Group A, and in Group B it significantly decreased from 43.7 ± 2.3 v/HPF to 11.5 ± 1.6 v/HPF. The reduction of MVD was significantly higher in Group B compared with in Group A (P < 0.0001). Moreover, there was a significant reduction in bacterial density (assessed by bacterial index) in the cutaneous lesions of in Group B (decreased from 4.9 ± 0.3 to 1.4 ± 0.2) compared with in Group A (decreased from 5.1 ± 0.4 to 2.3 ± 0.4).ConclusionThe synergistic effect of MDT and minocycline seems to be promising in the treatment of lepromatous leprosy. It significantly reduces angiogenesis and rapidly eliminates lepra bacilli from the skin that enables a rapid control and elimination of the disease.

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Angiogenesis in Cutaneous Lesions of Leprosy

Cited by 11 publications

References 18 publications

Application of Angiogenesis to Clinical Dermatology

Application of Angiogenesis to Clinical Dermatology

Tuberculosis verrucosa cutis lesions exhibit a greater microvessel count than lupus vulgaris lesions

Inhibition of angiogenesis as a new therapeutic target in the treatment of lepromatous leprosy

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