Angiogenesis in Disease

Mendola, Diego La; Trincavelli, Maria Letizia; Martini, Claudia

doi:10.3390/ijms231810962

Cited by 25 publications

(11 citation statements)

References 30 publications

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“…Recent studies suggest that angiogenesis is a key factor in the development of many diseases, including cancer, diabetic retinopathy, autoimmune diseases, cerebral ischemia, cardiovascular disease, and delayed wound healing. Thus, modeling and examining vascular structure and function is crucial for studying the physiology of vascularized tissues and organs in the human body [ 11 – 13 ]. In recent years, there has been growing interest in the generation of networks that model the vasculature and vascularized tissues in vitro, and these models provide new tools for basic and applied research [ 14 – 16 ].…”

Section: Introductionmentioning

confidence: 99%

Technology for the formation of engineered microvascular network models and their biomedical applications

Li,

Shang,

Zeng

et al. 2024

Nano Convergence

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Tissue engineering and regenerative medicine have made great progress in recent decades, as the fields of bioengineering, materials science, and stem cell biology have converged, allowing tissue engineers to replicate the structure and function of various levels of the vascular tree. Nonetheless, the lack of a fully functional vascular system to efficiently supply oxygen and nutrients has hindered the clinical application of bioengineered tissues for transplantation. To investigate vascular biology, drug transport, disease progression, and vascularization of engineered tissues for regenerative medicine, we have analyzed different approaches for designing microvascular networks to create models. This review discusses recent advances in the field of microvascular tissue engineering, explores potential future challenges, and offers methodological recommendations.

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Section: Introductionmentioning

confidence: 99%

Technology for the formation of engineered microvascular network models and their biomedical applications

Li,

Shang,

Zeng

et al. 2024

Nano Convergence

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“…The angiogenic switch is characterized by enhanced localized vascularity as a consequence of an impaired balance of the autocrine and paracrine activities of proangiogenic and antiangiogenic factors [7][8][9]. The most potent angiogenic promotors of tumors are angiopoietins (Ang), vascular endothelial growth factors (VEGF), and basic fibroblast growth factor (bFGF) [5].…”

Section: Introductionmentioning

confidence: 99%

Prognostic value of circulatory growth factors to predict responsiveness to chemotherapy and remission status of patients with acute myeloid leukemia

Bani-Ahmad,

Ghanem

2024

Arch Med Sci

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IntroductionTumor neovascularization, an essential requirement for malignant disease progression and metastasis, depends on the dysregulation of pro-angiogenic and anti-angiogenic activities. This study aimed to investigate the utilization of circulatory angiopoietins (Ang-1 and Ang-2), vascular endothelial growth factor (VEGF-A and VEGF-C), and basic fibroblast growth factor (bFGF) as a prognostic tool for acute myeloid leukemia (AML).Material and methodsTwenty-four AML patients who were under chemotherapeutic intervention were included. Patients’ relapse status, responsiveness to chemotherapy, and remission status were obtained from their medical profiles. For comparative purposes, fifteen healthy subjects were included. Serum levels of growth factors were measured.ResultsAs compared to control subjects, AML patients had significantly lower average levels of Ang-1 (170.8 ±12.7 versus 59.2 ±12.5 ng/ml) and VEGF-A (56.0 ±13.1 versus 98.6 ±11.9 ng/dl) that coincide with a higher average level of Ang-2 (18.5 ±4.1 ng/ml versus 7.5 ±0.8 ng/ml). Spearman’s correlation analysis defined a significant association of sAng-1 and sAng-2 with patients’ response to chemotherapy ( = 0.488) and remission status ( = 0.476), respectively. According to the receiver operating characteristic (ROC) curve, downregulation of Ang-1 has good predictivity for poor responsiveness to chemotherapy (AUC = 0.781, p < 0.05) while upregulation of sAng-2 has good predictivity for failed remission status (AUC = 0.779, p < 0.05).ConclusionsIn the context of AML, dysregulated circulatory levels of Ang-1 and Ang-2 are suggested prognostic markers to provide useful predictivity of patients’ adverse responsiveness to chemotherapy and remission status, respectively.

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“…This intricate balance has spurred the emergence of potential therapeutic avenues known as angiogenesis-based therapies [5]. Over the last few decades, these therapies have been widely involved in the medical field, including promoting or inhibiting angiogenesis [6,7].…”

Section: Introductionmentioning

confidence: 99%

Alternating Current-Electric Field Inducing Chorio Allantoic Membrane (CAM) Angiogenesis through Exogenous Growth Factor Intervention

Palupi,

Retnoaji,

Astuti

et al. 2024

Curr. Appl. Sci. Technol.

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Angiogenesis is widely used in various therapies by promoting or inhibiting the formation of new blood vessels. The use of Alternating Current-Electric Fields (AC-EF) in Electro-Capacitive Cancer Therapy (ECCT) showed its potential as an anti-cancer device, and is characterized by its anti-proliferative and pro-apoptotic effects. However, the role of AC-EF in angiogenesis remains unclear. To investigate the effects of AC-EF on CAM angiogenesis, we used the ex ovo culture method of chorioallantoic membrane (CAM). A basic fibroblast growth factor (bFGF) dose of 30 ng/µL was administered as an exogenous growth factor. The ECCT device, generating AC-EF of 150 kHz and 18 Vpp, was exposed to the CAMs. Subsequently, the 24 CAMs of chick embryo were divided into four groups. Two groups were non-bFGF-induced CAM, while the other two were bFGF-induced CAM, and each group was exposed either with or without AC-EF. The vascularization was evaluated through macroscopic observation, while vascular endothelial growth factor A (VEGFA) gene expression was measured using qPCR. The data were statistically analyzed using ANOVA with GraphPad Prism 9.5. The results showed that an AC-EF exposure had no effects on normal CAM angiogenesis (P>0.05). Moreover, VEGFA gene expression did not show significant upregulation (P>0.05) in the bFGF-induced CAM with or without AC-EF exposure. Interestingly, the number of new blood vessels was significantly higher (P<0.05) in the bFGF-induced with AC-EF exposure than in the non-bFGF-induced group. In conclusion, AC-EF of ECCT did not affect normal angiogenesis. AC-EF may trigger CAM angiogenesis with bFGF induction. This observation suggested that AC-EF of intermediate frequency could enhance angiogenesis by administration of external growth factors, offering a potential avenue for addressing obstructive vascular conditions.

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Angiogenesis in Disease

Abstract: Angiogenesis is a multi-step process by which new blood capillaries are formed starting from preexisting functional vessels [...]

Cited by 25 publications

References 30 publications

Technology for the formation of engineered microvascular network models and their biomedical applications

Technology for the formation of engineered microvascular network models and their biomedical applications

Prognostic value of circulatory growth factors to predict responsiveness to chemotherapy and remission status of patients with acute myeloid leukemia

Alternating Current-Electric Field Inducing Chorio Allantoic Membrane (CAM) Angiogenesis through Exogenous Growth Factor Intervention

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