Angiogenesis in triple-negative adenoid cystic carcinomas of the breast

Vranić, Semir; Frković‐Grazio, Snjez̆ana; Bilalović, Nurija; Gatalica, Zoran

doi:10.1007/s00428-011-1144-4

Cited by 10 publications

(4 citation statements)

References 35 publications

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“…Our results showed that the f values were higher in TNBC compared to HER2-type cancers. This correlates with the research results of Vranic [32]; they thought TNBC exhibited increased f compared with other subtypes, which suggests that this type of cancer undergoes increased tumor angiogenesis. This is the exact reason for the increase in APT values.…”

Section: Discussionsupporting

confidence: 89%

Three-Dimensional Turbo-Spin-Echo Amide Proton Transfer-weighted and Intravoxel Incoherent Motion Imaging MRI assessing the Triple-Negative Breast Cancer

Zhang,

Shao,

et al. 2023

Preprint

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Background：Accurate diagnosis of TNBC is essential before initiating therapeutic intervention.Intravoxel incoherent motion imaging (IVIM) MRI an alternative to breast biopsy for sub-typing of the triple-negative breast cancer (TNBC).amide proton transfer-weighted (APTw) MRI provides a new method for the diagnosis of TNBC.To investigate the potential of APTw MRI in assessing TNBC and to assess whether APTw MRI can enhance the diagnostic value of IVIM in breast MRI. Methods This prospective study involved 115 patients with suspected breast tumors who underwent both breast APTw and IVIM MRI. The APTw, diffusion coefficient (D), pseudo diffusion coefficient (D*), and perfusion fraction (f) values along with histological subtype, grade, and prognostic factors (Ki-67, estrogen receptor (ER), progesterone receptor (PR), human epidermal growth factor receptor-2 (HER-2), lymph node metastasis, and maximum lesion diameter) were compared. APT values were further analyzed in relation to biological subtypes, Ki-67 labeling index, and nuclear grades (NGs). Results A total of 67 participants (mean age, 64 years, ranges 29-71) were included in the evaluation. The TNBC (3.52 ± 0.38%) exhibited significantly higher APT values compared to the luminal A-type cancers (2.16 ± 1.12%) (P = 0.04). The luminal B cancers showed significantly lower f and Dmax values than the TN-type cancers (P=0.007,0.010). The HER2 cancers showed significantly lower APT values than TN-type ones (P=0.010).The APT value were notably higher in high-Ki-67 (2.80±1.39%) than in low-Ki-67 cancers (2.20±1.88%) (P = 0.045). There are significant difference in APT value was observed between NG1, NG2 and NG3 cancers (P=0.049). And APT value was also significant difference in stages T1 cancers (P=0.027). The combined diagnostic efficiency between TNBC from Luminal A was 0.955. Conclusion The combination of APTw and IVIM MRI holds promise for distinguishing TNBC by discerning molecular subtypes of breast cancers.

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Section: Discussionsupporting

confidence: 89%

Three-Dimensional Turbo-Spin-Echo Amide Proton Transfer-weighted and Intravoxel Incoherent Motion Imaging MRI assessing the Triple-Negative Breast Cancer

Zhang,

Shao,

et al. 2023

Preprint

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“…TNBC samples exhibited increased fast ADC and fraction of fast ADC values compared with other subtypes, which suggests that this type cancer undergoes increased tumor angiogenesis. It has been reported that TNBC also exhibited increased MVD compared with other subtypes of cancer ( 52 ). The tumor edge tissues from TNBC samples exhibited increased fraction of fast ADC values compared with other tissue types, including TNBC tumor tissue which may be associated with increased blood supply to the tumor and the internal necrosis of the tumor.…”

Section: Discussionmentioning

confidence: 97%

Intravoxel incoherent motion magnetic resonance imaging for breast cancer: A comparison with benign lesions and evaluation of heterogeneity in different tumor regions with prognostic factors and molecular classification

Zhao

Zhang

et al. 2018

Oncol Lett

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The objective of the present study was to compare the differentiation between breast cancer and benign breast lesions and study regional distribution characteristics in various subtypes of breast cancer using intravoxel incoherent motion (IVIM) parameters. This retrospective study involved 119 patients with breast cancer and 22 patients with benign breast lesions, who underwent 3.0T breast magnetic resonance imaging examinations. The apparent diffusion coefficient (ADC) and IVIM parameters (slow ADC, fast ADC and fraction of fast ADC) were obtained from patients with breast cancer and benign lesions using diffusion-weighted imaging (DWI) with b-values of 0, 50, 100, 150, 200, 400, 500, 1,000 and 1,500 sec/mm2. Compared with patients with benign breast lesions, patients with breast cancer exhibited decreased ADC (P<0.001), slow ADC (P<0.001) and fast ADC (P<0.001) values, and higher fraction of fast ADC (P<0.001) values. Tumors with metastatic axillary lymph nodes demonstrated increased fraction of fast ADC values (P<0.001) and decreased slow ADC values (P<0.001) compared with tumors without metastatic axillary lymph nodes. The Fast ADC values of tumor tissues in estrogen receptor (ER) and progesterone receptor (PR) negative groups were higher than in positive groups (P<0.001), and the slow ADC values of tumor tissues were lower in ER and PR negative groups than positive groups (P<0.001). Luminal B (HER2- negative) tumor (P<0.001) and peritumor (P<0.001) tissues exhibited decreased fraction of fast ADC values, in comparison with other subtypes. Triple-negative breast cancer (TNBC) tumor tissue exhibited increased fast ADC (P<0.001) and fraction of fast ADC values (P<0.001), and decreased slow ADC values (P<0.001), when compared with other subtypes. The TNBC tumor edge tissues had increased fraction of fast ADC values compared with other subtypes (P<0.01) and TNBC tumor tissues (P<0.05). Therefore, the IVIM parameters of tumor, tumor edge and peritumor tissues in various subtypes of breast cancer may be useful for differentiation of breast cancer subtypes and to assess the invasive extent of the tumors.

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“…Our group has recently reported on two breast AdCCs with high-grade transformation; our findings confirmed that progression occurred via the acquisition of additional genetic events and/or clonal selection; however, none of the genetic alterations reported in the progression of salivary gland AdCCs were found in breast AdCCs. 7 In a distinct study of a single breast AdCC metastasizing to the kidney, 92 PIK3CA and PTEN mutations were found in both the primary and metastatic tumors, but, the metastatic deposits showed increased PTEN promoter methylation and lower PTEN gene expression levels. It seems therefore unlikely that a single genetic event is responsible for the high-grade transformation observed in human AdCCs.…”

Section: Tnbcs: the Importance Of Histologic Subtypingmentioning

confidence: 99%

Triple-negative breast cancer: the importance of molecular and histologic subtyping, and recognition of low-grade variants

et al. 2016

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Triple-negative breast cancers (TNBCs), defined by lack of expression of estrogen receptor, progesterone receptor and HER2, account for 12–17% of breast cancers and are clinically perceived as a discrete breast cancer subgroup. Nonetheless, TNBC has been shown to constitute a vastly heterogeneous disease encompassing a wide spectrum of entities with marked genetic, transcriptional, histological and clinical differences. Although most TNBCs are high-grade tumors, there are well-characterized low-grade TNBCs that have an indolent clinical course, whose natural history, molecular features and optimal therapy vastly differ from those of high-grade TNBCs. Secretory and adenoid cystic carcinomas are two histologic types of TNBCs underpinned by specific fusion genes; these tumors have an indolent clinical behavior and lack all of the cardinal molecular features of high-grade triple-negative disease. Recent studies of rare entities, including lesions once believed to constitute mere benign breast disease (e.g., microglandular adenosis), have resulted in the identification of potential precursors of TNBC and suggested the existence of a family of low-grade triple-negative lesions that, despite having low-grade morphology and indolent clinical behavior, have been shown to harbor the complex genomic landscape of common forms of TNBC, and may progress to high-grade disease. In this review, we describe the heterogeneity of TNBC and focus on the histologic and molecular features of low-grade forms of TNBC. Germane to addressing the challenges posed by the so-called triple-negative disease is the realization that TNBC is merely a descriptive term, and that low-grade types of TNBC may be driven by distinct sets of genetic alterations.

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Angiogenesis in triple-negative adenoid cystic carcinomas of the breast

Cited by 10 publications

References 35 publications

Three-Dimensional Turbo-Spin-Echo Amide Proton Transfer-weighted and Intravoxel Incoherent Motion Imaging MRI assessing the Triple-Negative Breast Cancer

Three-Dimensional Turbo-Spin-Echo Amide Proton Transfer-weighted and Intravoxel Incoherent Motion Imaging MRI assessing the Triple-Negative Breast Cancer

Intravoxel incoherent motion magnetic resonance imaging for breast cancer: A comparison with benign lesions and evaluation of heterogeneity in different tumor regions with prognostic factors and molecular classification

Triple-negative breast cancer: the importance of molecular and histologic subtyping, and recognition of low-grade variants

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