Angiogenesis Meets Skeletogenesis: The Cross-Talk between Two Dynamic Systems

Abstract

In this chapter, we describe the complex relationship between angiogenesis and skeletogenesis. While much is known about the interactions of these two dynamic systems for bones that ossify via a cartilage template, comparatively litle is known about directly ossifying bones. Most of the bones of the head develop from osteogenic condensations and undergo intramembranous (direct) ossiication during development. Our understanding of the relationship between osteogenic cell condensations (in particular) and angiogenesis is currently inadequate and prevents a comprehensive understanding of vertebrate head development. This chapter highlights our understanding of both direct and indirectly ossifying bones shedding light on where there are important gaps in our understanding.