Angiogenesis Predicts Poor Prognosis in Gastric Carcinoma

Abstract

Background/Aims: New prognostic factors in gastric carcinoma to determine the prognosis of the disease or to identify patients who will benefit from adjuvant therapy are being researched. The aim of this study is to investigate the correlation between microvessel count (MVC) and various clinicopathologic features in gastric carcinoma in order to evaluate the role of angiogenesis on the prognosis of gastric cancer. Methods: Fifty-seven patients who underwent surgical intervention for gastric carcinoma between 1993 and 1997 were reviewed retrospectively. The relationship between MVC and various clinicopathological features was assessed. The effect of angiogenesis on overall survival and the role of MVC and other prognostic factors on distant metastases were assessed by multivariate analysis. Microvessels were outlined by anti-factor VIII, which is a specific monoclonal antibody to factor VIII in vessel endothelial cells, using the streptavidin-biotin method and counted under light microscopy ×200 magnification. Results: There was no correlation between MVC and age or sex of the patient, duration of symptoms or tumor size. Proximally located, undifferentiated, diffuse type, serosal invasion positive, lymph node invasion positive, advanced stage, or distantly metastasized tumors had higher MVCs. Higher MVCs affected the overall survival adversely. Lymph node metastasis, serosal invasion and MVC were found as independent prognostic factors affecting distant metastases. MVC was the sole factor affecting recurrent liver metastasis. Conclusion: It is concluded that MVC in gastric carcinoma may be a valuable prognostic factor to predict patients at high-risk for possible recurrences and to decide on postoperative adjuvant therapy.

The Subserosal Elastic Lamina: An Anatomic Landmark for Stratifying pT3 Colorectal Cancer

“…Several investigators have reported that there was a close correlation between small vessel counts and liver metastasis in the colorectum and other organs. [18][19][20][21] Accordingly, we speculate that carcinoma cells traveled to the liver via proliferated small vessels.…”

Clinicopathologic Features of Mucinous Gastric Carcinoma

“…Erenoglu et al [10]reported that microvessel count may be a valuable prognostic factor to predict patients at high risk for possible recurrences. Histologic type as a prognostic factor is still controversial [11, 12].…”

Estudo citofotométrico da expressão do marcador tumoral Fator VIII e fatores prognósticos no adenocarcinoma gástrico

“…No estudo da angiogênese com Fator VIII, Erenoglu et al 6 , não encontraram correlação entre densidade microvascular e idade ou sexo dos pacientes no câncer gástrico. Dos marcadores que analisam a evolução do câncer gástrico os que representam a proliferação celular 8 e a angiogênese 19 parecem ser os melhores.…”

“…O estudo realizado por Erenoglu et al 6 em 57 pacientes com câncer gástrico encontrou correlação entre densidade microvascular e parâmetros como tipo difuso e indiferenciado, invasão de serosa e linfonodal, estadio avançado e metástase distal, nos quais se apresentaram com maior densidade vascular e maiores índices, afetando a sobrevida adversamente. Os autores concluiram que a densidade microvascular no carcinoma gástrico pode ser fator prognóstico valioso para predizer pacientes com alto risco para recorrência e para decidir terapia adjuvante pós-operatória.…”