Angiogenesis: The VE-Cadherin Switch

Wallez, Yann; Vilgrain, Isabelle; Huber, Philippe

doi:10.1016/j.tcm.2005.11.008

Cited by 119 publications

(110 citation statements)

References 38 publications

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“…The researchers also investigate the role of VEcadherin in mediating tumor cell-induced angiogenesis since it has been previously linked to tumor angiogenesis in mice (Wallez et al, 2006). VE-cadherin is a cell-cell adhesion molecule that mediates endothelial cell survival, proliferation and vessel tube formation.…”

Section: Early Embryo Xenotransplantant Modelmentioning

confidence: 99%

Catch of the day: zebrafish as a human cancer model

2008

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Zebrafish are making big waves in the field of cancer research. The effect has been widespread and continues to gain speed as more and more cancer researchers ride the wave of zebrafish biology. This has been largely due to the development of transgenic and xenograft models of cancer, which recapitulate many aspects of different human cancers including lymphoblastic T-cell leukemia, pancreatic cancer, melanoma and rhabdomyosarcoma. These models are already being utilized by academia and industry to search for genetic and chemical modifiers of cancer with success. The attention has been further stimulated by the amenability of zebrafish to pharmacological testing and the superior imaging properties of fish tissues that allow visualization of cancer progression and angiogenesis in live animals. This review summarizes the current zebrafish models of cancer and discusses their utility in human cancer research and future directions in the field.

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Section: Early Embryo Xenotransplantant Modelmentioning

confidence: 99%

Catch of the day: zebrafish as a human cancer model

2008

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“…Importantly, VE-cadherin tyrosine phosphorylation was weak or undetectable in endothelial cells from resting tissues (Lambeng et al, 2005). Therefore, modulation of the tyrosine phosphorylation status of VE cadherin would be critical for regulating angiogenesis, and permeability (Wallez et al, 2006).…”

Section: Introductionmentioning

confidence: 99%

Src kinase phosphorylates vascular endothelial-cadherin in response to vascular endothelial growth factor: identification of tyrosine 685 as the unique target site

et al. 2006

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“…Therefore, we hypothesize that the endothelial P2Y 2 R assists in monocyte diapedesis by interacting with VE-cadherin and disrupting endothelial junctions localized at the site of leukocyte passage. VE-cadherin has been well recognized for its role in regulating the endothelial permeability barrier and leukocyte recruitment [261][262][263][264][265][266][267]. The N-terminal extracellular domain of VEcadherin provides tight adhesion between endothelial cells through Ca 2+ -dependent homophilic interaction, whereas the cytoplasmic domain interacts with various intracellular binding partners, including α-, β-, and p120 catenins, providing a linkage to the actin cytoskeleton [268].…”

Section: Proinflammatory P2y 2 R Functions In Endotheliummentioning

confidence: 99%