2012
DOI: 10.1097/aog.0b013e318256187f
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Angiogenic and Fibrinolytic Factors in Blood During the First Half of Pregnancy and Adverse Pregnancy Outcomes

Abstract: II.

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Cited by 59 publications
(62 citation statements)
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“…4 Previous studies have reported that lower levels of PlGF and higher levels of sFlt-1 in the first and second trimester of pregnancy are associated with increased risk of preeclampsia, preterm birth, and fetal growth restriction. 7 In this study, we observed that lower second trimester maternal PlGF levels are associated with narrower retinal arteriolar caliber in childhood. This association was not explained by maternal sociodemographic and lifestyle-related characteristics, pregnancy complications, birth characteristics, or childhood factors.…”
Section: Interpretation Of Main Findingsmentioning
confidence: 55%
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“…4 Previous studies have reported that lower levels of PlGF and higher levels of sFlt-1 in the first and second trimester of pregnancy are associated with increased risk of preeclampsia, preterm birth, and fetal growth restriction. 7 In this study, we observed that lower second trimester maternal PlGF levels are associated with narrower retinal arteriolar caliber in childhood. This association was not explained by maternal sociodemographic and lifestyle-related characteristics, pregnancy complications, birth characteristics, or childhood factors.…”
Section: Interpretation Of Main Findingsmentioning
confidence: 55%
“…11,27 Also, studies among children aged 6 to 8 and 12.7 years have shown that narrower retinal arterioles were significantly correlated with increased risks of hypertension. 12 Our results suggest that reduced maternal second trimester PlGF levels, which are associated with a suboptimal placenta development and the risk of adverse pregnancy outcomes, 7,8 might also lead to narrowing of microvasculature in later life. Reduced PlGF levels can disrupt the normal growth of the vessels and the process of neoangiogenesis, which might lead to permanent alterations in the microvessel structure.…”
Section: Interpretation Of Main Findingsmentioning
confidence: 94%
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“…4,5 Meanwhile, proteomic, metabolomic, and gene expression profiling of maternal plasma, urine, or peripheral blood mononuclear cells have been applied to search for new biomarkers and potential pathogenetic pathways. 40 It should be acknowledged that these techniques are not suited for simple, low-cost routine clinical prediction of preeclampsia but for the identification of new biomarkers.…”
Section: New Developmentsmentioning
confidence: 99%
“…4,5 Compared with normal pregnancies, the serum concentration of the antiangiogenic soluble Fms-like tyrosine kinase 1 (sFlt-1) is markedly increased, whereas that of placental growth factor (PlGF) is decreased in preeclampsia. 4,[6][7][8][9][10] Because of the reciprocal changes of these markers, the ratio of sFlt-1/PlGF appears to be a superior marker of (early onset) preeclampsia compared with the individual values of these markers.…”
mentioning
confidence: 99%