Angiogenic and lymphangiogenic profiles in histological variants of papillary thyroid carcinoma

Skuletic, Vesna; Radosavljević, Gordana; Pantic, Jelena; Marković, Bojana Simović; Jovanović, Ivan; Janković, Nikola; Petrović, Dušica; Jevtović, Andra; Džodić, Radan; Arsenijević, Nebojša

doi:10.20452/pamw.3999

Cited by 8 publications

(7 citation statements)

References 25 publications

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“…A denser angiogenetic pattern was also reported in tumors with a higher metastatic potential[ 47 ]. Additionally, MVD has been found significantly higher in malignancies with high risk characteristics, such as extrathyroidal and vascular invasion[ 48 ].…”

Section: Discussionmentioning

confidence: 99%

Microvessel density in differentiated thyroid carcinoma: A systematic review and meta-analysis

Perivoliotis¹,

Samara²,

Koutoukoglou³

et al. 2022

WJM

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BACKGROUND Microvessel density (MVD) has been proposed as a direct quantification method of tumor neovascularization. However, the current literature regarding the role of MVD in differentiated thyroid carcinoma (DTC) remains inconclusive. AIM To appraise the effect of tumoral MVD on the survival of patients with DTC. METHODS This meta-analysis was based on the PRISMA guidelines and the Cochrane Handbook for Systematic Reviews of Interventions. The electronic databases Medline, Web of Science, and Scopus were systematically screened. A fixed-effects or random-effects model was used, according to the Cochran Q test. The data were then extracted and assessed on the basis of the Reference Citation Analysis ( ). RESULTS A total of nine studies were included in the present study. Superiority of low MVD tumors in terms of 10-year disease free survival (OR: 0.21, 95%CI: 0.08–0.53) was recorded. Lowly vascularized thyroid cancers had a lower recurrence rate (OR: 13.66, 95%CI: 3.03–61.48). Moreover, relapsing tumors [weighed mean difference (WMD): 11.92, 95%CI: 6.32–17.52] or malignancies with regional lymph node involvement (WMD: 8.53, 95%CI: 0.04–17.02) presented with higher tumoral MVD values. CONCLUSION MVD significantly correlates with the survival outcomes of thyroid cancer patients. However, considering several study limitations, further prospective studies of higher methodological and quality level are required.

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Section: Discussionmentioning

confidence: 99%

Microvessel density in differentiated thyroid carcinoma: A systematic review and meta-analysis

Perivoliotis¹,

Samara²,

Koutoukoglou³

et al. 2022

WJM

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“…As we all know, tumor cells often invade LNs from the surrounding cortex, and the invasion is accompanied by the formation of new blood vessels. Therefore, abnormal vascular hyperplasia of LNs is a typical biological feature of metastatic LNs [9] . However, the ultrasonic grayscale images of early metastatic LNs are often atypical and di cult to be detected by our naked eyes.…”

Section: Introductionmentioning

confidence: 99%

A Novel Noninvasive Diagnostic Method for Suspicious Cervical Lymph Nodes— Superb Microvascular Imaging

Xu,

Zhou,

et al. 2024

Preprint

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Background To explore the diagnostic value of superb microvascular imaging (SMI) for ultrasonically uncertain lymph nodes (LNs). Methods Our center prospectively collected clinical and imaging data of 74 patients who underwent fine-needle aspiration biopsy and thyroglobulin measurement from January 2022 to June 2022. First, univariate analysis was performed to obtain relevant variables that differed between benign and malignant LN groups. Then spearman correlation was used to analyze the correlation between effective variables and pathological results. Finally, receiver operating characteristic was used to analyze the diagnostic efficiency of effective variables. Results In this study, there were 43 benign LNs and 31 malignant LNs. In univariate analysis, gender, age, CDFI diagnosis results and SMI diagnosis results were significantly different in the differentiation of benign and malignant LNs (P = 0.026, P = 0.041, P = 0.001, P < 0.001). CDFI and SMI diagnosis results had good correlated with pathological findings (r = 0.403, P < 0.001, r = 0.707, P < 0.001). The diagnostic efficiency of SMI (AUC = 0.856, P < 0.001) was higher than that of CDFI (AUC = 0.704, P = 0.003). And the diagnostic results of SMI were superior to those of CDFI. The number of feeding vessels showed by CDFI and SMI in malignant LNs was higher than that in benign LNs (2.00 vs. 1.00, 3.00 vs. 2.00, all P < 0.001). In all enrolled LNs, SMI showed significantly more vessels than CDFI (2.53 ± 1.47 vs. 1.50 ± 1.13, P < 0.001). Conclusions SMI is better than CDFI in displaying small feeding vessels and has important diagnostic value in judging the nature of LNs with ultrasound uncertainty.

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“…The incidence of PTC has continued to increase in the past few decades [2]. Histopathologically, PTC is normally well-differentiated and displays multiple histological variants [3]. It is usually multifocal, and characterized by intraglandular metastasis from a single primary tumor or co-existence of diverse primary tumors [4].…”

Section: Introductionmentioning

confidence: 99%

Long non-coding ROR promotes the progression of papillary thyroid carcinoma through regulation of the TESC/ALDH1A1/TUBB3/PTEN axis

Fan

et al. 2022

Cell Death Dis

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Papillary thyroidal carcinoma (PTC) is a common endocrine cancer that plagues people across the world. The potential roles of long non-coding RNAs (lncRNAs) in PTC have gained increasing attention. In this study, we aimed to explore whether lncRNA ROR affects the progression of PTC, with the involvement of tescalcin (TESC)/aldehyde dehydrogenase isoform 1A1 (ALDH1A1)/βIII-tubulin (TUBB3)/tensin homolog (PTEN) axis. PTC tumor and adjacent tissues were obtained, followed by measurement of lncRNA ROR and TESC, ALDH1A1, and TUBB3 expression. Interactions among lncRNA ROR, TESC, ALDH1A1, TUBB3, and PTEN were evaluated by ChIP assay, RT-qPCR, or western blot analysis. After ectopic expression and depletion experiments in PTC cells, MTT and colony formation assay, Transwell assay, and flow cytometry were performed to detect cell viability and colony formation, cell migration and invasion, and apoptosis, respectively. In addition, xenograft in nude mice was performed to test the effects of lncRNA ROR and PTEN on tumor growth in PTC in vivo. LncRNA ROR, TESC, ALDH1A1, and TUBB3 were highly expressed in PTC tissues and cells. Overexpression of lncRNA ROR activated TESC by inhibiting the G9a recruitment on the promoter of TESC and histone H3-lysine 9me methylation. Moreover, TESC upregulated ALDH1A1 expression to increase TUBB3 expression, which then reduced PTEN expression. Overexpression of lncRNA ROR, TESC, ALDH1A1 or TUBB3 and silencing of PTEN promoted PTC cell viability, colony formation, migration, and invasion while suppressing apoptosis. Moreover, overexpression of lncRNA ROR increased tumor growth by inhibiting PTEN in vivo. Taken together, the current study demonstrated that lncRNA ROR mediated TESC/ALDH1A1/TUBB3/PTEN axis, thereby facilitating the development of PTC.

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Angiogenic and lymphangiogenic profiles in histological variants of papillary thyroid carcinoma

Cited by 8 publications

References 25 publications

Microvessel density in differentiated thyroid carcinoma: A systematic review and meta-analysis

Microvessel density in differentiated thyroid carcinoma: A systematic review and meta-analysis

A Novel Noninvasive Diagnostic Method for Suspicious Cervical Lymph Nodes— Superb Microvascular Imaging

Long non-coding ROR promotes the progression of papillary thyroid carcinoma through regulation of the TESC/ALDH1A1/TUBB3/PTEN axis

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