Angiogenic biomaterials to promote therapeutic regeneration and investigate disease progression

Ngo, Mai T.; Harley, Brendan A.C.

doi:10.1016/j.biomaterials.2020.120207

Cited by 47 publications

(26 citation statements)

References 313 publications

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“…Despite lacking any inherent biological functionality, these materials can be outfitted with bioactive modalities such as growth factors, binding, and degradative protein sequences to mimic the aspects of native tissues, which is called the bottom-up approach ( Fig. 9 b) [ 321 , 325 ]. After recognizing the biodegradable matrix materials suitable for vascular invasion, researchers can combine them with other BTE materials as needed [ 252 ].…”

Section: Bioactive Molecular Delivery Based On Bone-healing Mechanismmentioning

confidence: 99%

Bone physiological microenvironment and healing mechanism: Basis for future bone-tissue engineering scaffolds

Zhu

Zhang

Miao

et al. 2021

Bioactive Materials

283

214

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Bone-tissue defects affect millions of people worldwide. Despite being common treatment approaches, autologous and allogeneic bone grafting have not achieved the ideal therapeutic effect. This has prompted researchers to explore novel bone-regeneration methods. In recent decades, the development of bone tissue engineering (BTE) scaffolds has been leading the forefront of this field. As researchers have provided deep insights into bone physiology and the bone-healing mechanism, various biomimicking and bioinspired BTE scaffolds have been reported. Now it is necessary to review the progress of natural bone physiology and bone healing mechanism, which will provide more valuable enlightenments for researchers in this field. This work details the physiological microenvironment of the natural bone tissue, bone-healing process, and various biomolecules involved therein. Next, according to the bone physiological microenvironment and the delivery of bioactive factors based on the bone-healing mechanism, it elaborates the biomimetic design of a scaffold, highlighting the designing of BTE scaffolds according to bone biology and providing the rationale for designing next-generation BTE scaffolds that conform to natural bone healing and regeneration.

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Section: Bioactive Molecular Delivery Based On Bone-healing Mechanismmentioning

confidence: 99%

Bone physiological microenvironment and healing mechanism: Basis for future bone-tissue engineering scaffolds

Zhu

Zhang

Miao

et al. 2021

Bioactive Materials

283

214

View full text Add to dashboard Cite

show abstract

“…Angiogenesis is ubiquitous in tumor growth, invasion, progression, and metastasis of a vast majority of human cancers. 111 Therefore, targeting this process may potentially halt the growth and spread of cancers. 112 Some of the prominent FDA approved angiogenesis inhibitors currently used in cancer therapy (with their mode of action) include: Bevacizumab (VEGF-A antibody); Ramucirumab (VEGFR2 antibody); Sunitinib (Tyrosine Kinase Inhibitor); Sorafenib (Tyrosine Kinase Inhibitor); Pazopanib (Tyrosine Kinase Inhibitor); Lenvatinib (Tyrosine Kinase Inhibitor); and Cabozantinib (Tyrosine Kinase Inhibitor).…”

Section: Mgf-aunps But Not S-aunps Polarize Macrophages To Anti-tummentioning

confidence: 99%

Green Nanotechnology of MGF-AuNPs for Immunomodulatory Intervention in Prostate Cancer Therapy

Khoobchandani

Khan

Katti

et al. 2021

Preprint

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Men with castration-resistant prostate cancer (CRPC) face poor prognosis and increased risk of treatment-incurred adverse effects resulting in one of the highest mortalities among patient population globally. Immune cells act as double-edged sword depending on the tumor microenvironment, which leads to increased infiltration of pro-tumor (M2) macrophages. Development of new immunomodulatory therapeutic agents capable of targeting the tumor microenvironment, and hence orchestrating the differentiation of pro-tumor M2 macrophages to anti-tumor M1, would substantially improve treatment outcomes of CRPC patients. We report, herein, Mangiferin functionalized gold nanoparticles (MGF-AuNPs) and its immunomodulatory characteristics in treating prostate cancer. We provide evidence of immunomodulatory intervention of MGF-AuNPs in prostate cancers through observations of enhanced levels of anti-tumor cytokines (IL-12 and TNF-α) with concomitant reductions in the levels of pro-tumor cytokines (IL-10 and IL-6). In the treated groups, IL-12 was elevated to ten-fold while TNF-α was elevated to about fifty-fold; while IL-10 and IL-6 were reduced by two-fold. Ability of MGF-AuNPs to target splenic macrophages is invoked via targeting of NF-kB signaling pathway. Finally, therapeutic efficacy of MGF-AuNPs, in treating prostate cancer in vivo in tumor bearing mice, is described taking into consideration various immunomodulatory interventions triggered by this green nanotechnology-based nanomedicine agent.

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“…Thus, osteogenesis is a process coupled to vascularization during bone development and growth [ 17 ]. For this reason, angiogenic biomaterials are designed to promote vascularization and optimize bone regeneration [ 18 , 19 , 20 , 21 ]. In this context, nanoparticles of bioactive materials loaded with different drugs represent an interesting strategy to promote bone regeneration by stimulating osteogenesis and angiogenesis and inhibiting bone resorption [ 22 , 23 ].…”

Section: Introductionmentioning

confidence: 99%

Effects of Ipriflavone-Loaded Mesoporous Nanospheres on the Differentiation of Endothelial Progenitor Cells and Their Modulation by Macrophages

et al. 2021

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Angiogenic biomaterials are designed to promote vascularization and tissue regeneration. Nanoparticles of bioactive materials loaded with drugs represent an interesting strategy to stimulate osteogenesis and angiogenesis and to inhibit bone resorption. In this work, porcine endothelial progenitor cells (EPCs), essential for blood vessel formation, were isolated and characterized to evaluate the in vitro effects of unloaded (NanoMBGs) and ipriflavone-loaded nanospheres (NanoMBG-IPs), which were designed to prevent osteoporosis. The expression of vascular endothelial growth factor receptor 2 (VEGFR2) was studied in EPCs under different culture conditions: (a) treatment with NanoMBGs or NanoMBG-IPs, (b) culture with media from basal, M1, and M2 macrophages previously treated with NanoMBGs or NanoMBG-IPs, (c) coculture with macrophages in the presence of NanoMBGs or NanoMBG-IPs, and (d) coculture with M2d angiogenic macrophages. The endocytic mechanisms for nanosphere incorporation by EPCs were identified using six different endocytosis inhibitors. The results evidence the great potential of these nanomaterials to enhance VEGFR2 expression and angiogenesis, after intracellular incorporation by EPCs through clathrin-dependent endocytosis, phagocytosis, and caveolae-mediated uptake. The treatment of EPCs with basal, M1, and M2 macrophage culture media and EPC/macrophage coculture studies also confirmed the angiogenic effect of these nanospheres on EPCs, even in the presence of phagocytic cells.

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Angiogenic biomaterials to promote therapeutic regeneration and investigate disease progression

Cited by 47 publications

References 313 publications

Bone physiological microenvironment and healing mechanism: Basis for future bone-tissue engineering scaffolds

Bone physiological microenvironment and healing mechanism: Basis for future bone-tissue engineering scaffolds

Green Nanotechnology of MGF-AuNPs for Immunomodulatory Intervention in Prostate Cancer Therapy

Effects of Ipriflavone-Loaded Mesoporous Nanospheres on the Differentiation of Endothelial Progenitor Cells and Their Modulation by Macrophages

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