Angiogenic capacity of human omental stem cells

Abstract

CD34+ cell population of human omentum could be responsible for the clinical benefit of omental transplantation by promoting angiogenesis and synthesizing angiogenic growth factors to facilitate revascularization of injured tissue.

Omental Roll-Up: A Technique for Islet Engraftment in a Large Animal Model

“…Anticoagulation is not required with the described technique. The omentum is capable of making growth factors including VEGF [20,21] and although the omentum generally looks fatty, there is a significant microvasculature. It remains to be seen if islet durability might be improved in the omentum compared with intra-portal embolization.…”

Therapeutic Methods Against Insulin Resistance

“…This pancreatic ischemia caused by atherosclerotic plaques located at the mouth of the celiac trunk and its branches may be improved through two procedures: first, high-dose aspirin to increase the blood flow (recanalization) in the pancreas and thus, increase insulin secretion, based on its anti-inflammatory, anti-platelet and anti-thrombotic actions [17,18,[65][66][67][68], and second, omental transposition (pedicled graft) on the pancreas in order to revascularize the islets of Langerhans and provide stem cells from the omentum [14,70,71]. Through these two procedures, we could improve the function of the exocrine and endocrine pancreas.…”

“…While an omental transposition (pedicled graft) on the pancreas may be useful against pancreatic ischemia, due to revascularization (formation of new blood vessels), and besides this, provides stem cells from the omentum [14,70,71]. I believe that a transplantation of pancreatic islets would not be useful without revascularization.…”

Revascularization Options for Terminal Distal Ischemia

“…29 Omentum has long been appreciated to produce angiogenic factors that can be beneficial to healing. 30,31 The omentum has been found to improve wound healing and perfusion in Buerger disease in the lower extremity 32 ; this has been applied as a pedicled flap from the abdomen with the omentum stretched out into the leg 33,34 as well as a free flap in some instances. 35 This tissue has also been applied to the upper extremity as a pedicled flap (with later division of the pedicle) with surprisingly good results.…”