Angiogenic effect of intramuscular administration of basic fibroblast growth factor in atrophied muscles: an experimental study in the rat

Efthimiadou, Anna

doi:10.1136/bjsm.2005.024455

Cited by 11 publications

(7 citation statements)

References 18 publications

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“…Additionally, these growth factors accelerate the differentiation and proliferation of satellite cells and induce angiogenesis in muscle (re)growth (Smith et al . 1999; Efthimiadou et al . 2006).…”

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confidence: 99%

“…Fibroblast growth factor (FGF) J. Nakano and others Exp Physiol 94.9 pp 1005-1015 functions as an activator and as a mediator of skeletal muscle hypertrophy (Mitchell et al 1999). Additionally, these growth factors accelerate the differentiation and proliferation of satellite cells and induce angiogenesis in muscle (re)growth (Smith et al 1999;Efthimiadou et al 2006). Angiogenesis is strongly correlated with muscle (re)growth (Hudlická et al 1992;.…”

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confidence: 99%

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Low‐level laser irradiation promotes the recovery of atrophied gastrocnemius skeletal muscle in rats

Nakano

Kataoka²,

Sakamoto³

et al. 2009

Experimental Physiology

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Low-level laser (LLL) irradiation promotes proliferation of muscle satellite cells, angiogenesis and expression of growth factors. Satellite cells, angiogenesis and growth factors play important roles in the regeneration of muscle. The objective of this study was to examine the effect of LLL irradiation on rat gastrocnemius muscle recovering from disuse muscle atrophy. Eight-week-old rats were subjected to hindlimb suspension for 2 weeks, after which they were released and recovered. During the recovery period, rats underwent daily LLL irradiation (Ga-Al-As laser; 830 nm; 60 mW; total, 180 s) to the right gastrocnemius muscle through the skin. The untreated left gastrocnemius muscle served as the control. In conjunction with LLL irradiation, 5-bromo-2 -deoxyuridine (BrdU) was injected subcutaneously to label the nuclei of proliferating cells. After 2 weeks, myofibre diameters of irradiated muscle increased in comparison with those of untreated muscle, but did not recover back to normal levels. Additionally, in the superficial region of the irradiated muscle, the number of capillaries and fibroblast growth factor levels exhibited significant elevation relative to those of untreated muscle. In the deep region of irradiated muscle, BrdU-positive nuclei of satellite cells and/or myofibres increased significantly relative to those of the untreated muscle. The results of this study suggest that LLL irradiation can promote recovery from disuse muscle atrophy in association with proliferation of satellite cells and angiogenesis.

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confidence: 99%

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confidence: 99%

Low‐level laser irradiation promotes the recovery of atrophied gastrocnemius skeletal muscle in rats

Nakano

Kataoka²,

Sakamoto³

et al. 2009

Experimental Physiology

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“…Efthimiadou et al showed that the administration of bFGF to injured muscle increased angiogenesis and regenerated muscle. 26 The bFGF induces the migration of several inflammatory cells to the administration site, with angiogenesis, nerve regeneration, and muscle reconstruction. 27,28 In wound healing, bFGF induces angiogenesis in the early phase of reconstruction.…”

Section: Discussionmentioning

confidence: 99%

Effect of Fascia Implantation and Controlled Release of Basic Fibroblast Growth Factor for Muscle Atrophy in Rat Laryngeal Paralysis

Nagai

Nishiyama

Seino³

et al. 2021

Otolaryngol.--head neck surg.

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Objective To improve lateral thyroarytenoid (TA) muscle atrophy after laryngeal paralysis, reconstruction of the vascular network of the atrophied muscle is necessary. We therefore evaluated whether the controlled release of basic fibroblast growth factor (bFGF) with autologous fascia implantation could affect vascular reconstruction in the lateral TA muscle. Study Design Animal experiment. Setting Laboratory. Methods Unilateral laryngeal paralysis was induced in 20 rats. The rats were implanted with autologous fascia and a gelatin hydrogel sheet with or without 1 µg of bFGF (fascia and bFGF + fascia groups; n = 5 each) and with only a gelatin hydrogel sheet with bFGF (bFGF group: n = 5). Another group remained untreated (n = 5) at 4 months after paralysis. At 3 months since transplantation, intra- and intergroup comparisons of the muscle volumes and total area of blood vessels in the lateral TA muscle were performed. Results When compared with the untreated group, the bFGF + fascia group showed a significant increase in muscle volume ( P =.0008) and vascular area ( P =.0002) in the lateral TA muscle, whereas the other 2 treated groups demonstrated an insufficient effect. Conclusion bFGF + fascia implantation showed histologic improvement in severe laryngeal paralysis. We demonstrated that the decrease in lateral TA muscle mass after paralysis might be countered by the reconstruction of the vascular network. Our findings indicate that hypovascular and denervated areas of the laryngeal muscle can be regenerated by the implantation of growth factors and scaffolds with surgical stress. Level of evidence 5.

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“…We speculate that bFGF was effective for ATFV because bFGF has been reported to induce satellite cell propagation 20 and vascularization in the skeletal muscle. 21 Moreover, muscle regeneration is related to vessel increases around the damaged muscle, 22 which led to the idea that addition of bFGF to autologous fascia implantation would be effective.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of Autologous Fascia Implantation With Controlled Release of Fibroblast Growth Factor for Recurrent Laryngeal Nerve Paralysis Due to Long-term Denervation

Nagai

Nishiyama

Seino

et al. 2016

Ann Otol Rhinol Laryngol

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Angiogenic effect of intramuscular administration of basic fibroblast growth factor in atrophied muscles: an experimental study in the rat

Abstract: Intramuscular administration of b-FGF increases angiogenesis in both normal and atrophic rat gastrocnemius muscles at the injection area.

Cited by 11 publications

References 18 publications

Low‐level laser irradiation promotes the recovery of atrophied gastrocnemius skeletal muscle in rats

Low‐level laser irradiation promotes the recovery of atrophied gastrocnemius skeletal muscle in rats

Effect of Fascia Implantation and Controlled Release of Basic Fibroblast Growth Factor for Muscle Atrophy in Rat Laryngeal Paralysis

Evaluation of Autologous Fascia Implantation With Controlled Release of Fibroblast Growth Factor for Recurrent Laryngeal Nerve Paralysis Due to Long-term Denervation

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