Angiogenic growth factors in maternal and fetal serum in concordant and discordant twin pregnancies

Ruiz-Sacedón, Nerea; Perales‐Puchalt, Alfredo; Borras, Dolores; Gómez, Raúl; Perales, Alfredo

doi:10.3109/14767058.2013.845156

Cited by 10 publications

(9 citation statements)

References 7 publications

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“…This investigation is one of the largest studies of sFlt‐1 and PlGF levels in twin pregnancies to date, and only a few studies have compared sFlt‐1 and PlGF in twin pregnancies with and without PE. Our findings therefore have important implications for clinical practice for the diagnosis of suspected PE in twin pregnancies.…”

Section: Discussionmentioning

confidence: 84%

“…A possible pathophysiological explanation for the higher sFlt-1 and PlGF levels in our cohort of twin pregnancies with PE, in comparison with singleton pregnancies with PE, might be the higher placental mass that occurs in twin pregnancies 25 . A direct correlation between placental weight and levels of angiogenic factors is still a topic of controversy 26,27 . Furthermore, maternal blood volume is altered in twin pregnancies compared to singleton ones; an elevated extracellular volume in twin pregnancies might lead to different concentrations of serum factors in twins.…”

Section: Discussionmentioning

confidence: 99%

“…A larger placenta, artificial reproduction technologies (ART), including egg donation, advanced maternal age and higher rates of obesity might contribute to the 2–3‐fold higher incidence of PE in twin pregnancies compared with that in singleton pregnancies. However, only a few studies have evaluated the performance of the abovementioned markers for diagnosing PE in twin gestations.…”

Section: Introductionmentioning

confidence: 99%

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Maternal serum sFlt‐1/PlGF ratio in twin pregnancies with and without pre‐eclampsia in comparison with singleton pregnancies

Dröge

Herraı̀z

Zeisler³

et al. 2015

Ultrasound in Obstet & Gyne

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Section: Discussionmentioning

confidence: 84%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Maternal serum sFlt‐1/PlGF ratio in twin pregnancies with and without pre‐eclampsia in comparison with singleton pregnancies

Dröge

Herraı̀z

Zeisler³

et al. 2015

Ultrasound in Obstet & Gyne

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“…Twin pregnancies have an increased risk of developing PE per se , and may have different cut‐offs for the diagnosis of the disease. In many studies it has been found that the levels differ in twin compared with singleton pregnancies and appropriate cut‐off values need to be determined. Similarly , the reported sensitivities and specificities in the presented studies are specific for the study populations, which may not reflect each and every single ethnicity and region in the world.…”

Section: Prediction Of Diseasementioning

confidence: 99%

Angiogenic factors: potential to change clinical practice in pre‐eclampsia?

Cerdeira

Agrawal

Staff

et al. 2017

BJOG

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Pre‐eclampsia is a complex disease with significant maternal and fetal morbidity and mortality. Its syndromic nature makes diagnosis and management difficult. The field is rapidly evolving with the definition of pre‐eclampsia being challenged by some organisations, with proteinuria no longer being essential in the presence of other features. In the last decade, angiogenic factors, in particular soluble fms‐like tyrosine kinase 1 (sFlt‐1), have emerged as important molecules in the pathogenesis of pre‐eclampsia. Here we review the most recent evidence regarding the potential of these factors as biomarkers and therapeutic targets for pre‐eclampsia.Tweetable abstractA review of angiogenic factors, sFlt‐1 and PlGF, in the diagnosis, prediction and management of pre‐eclampsia.

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“…18–20 The timing of these changes in angiogenic balance may provide insight into the mechanism whereby preeclampsia risk is elevated in women carrying multiple gestations. Therefore, we followed women longitudinally through pregnancy and delivery to examine circulating maternal concentrations of placental growth factor (PlGF), sFlt-1, and s-endoglin in twin and singleton pregnancies.…”

Section: Introductionmentioning

confidence: 99%

Maternal circulating angiogenic factors in twin and singleton pregnancies

Faupel-Badger

McElrath

Lauria

et al. 2015

American Journal of Obstetrics and Gynecology

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Objective The purpose of this study was to compare longitudinally sampled maternal angiogenic proteins between singleton and twin pregnancies. Study Design Placental growth factor (PlGF), soluble fms-like tyrosine kinase-1 (sFlt-1), and soluble endoglin (sEng) from healthy pregnant women were quantified at 10, 18, 26 and 35 weeks’ gestation (n=91), and during the third trimester (31–39 weeks) and at delivery (33–41 weeks; n=41). Geometric means and 95% confidence intervals were calculated for gestational age adjusted angiogenic protein concentrations and compared between matched twin and singleton pregnancies. Results Maternal sFlt-1 concentrations and the sFlt-1/PlGF ratio were higher in twins than singletons across pregnancy and at delivery, with the greatest differences at week 35 [sFlt-1: 36916 vs. 10151 pg/mL; p<0.0001; sFlt-1/PlGF: 168.4 vs. 29.0; p<0.0001]. Maternal concentrations of s-endoglin also were higher in the third trimester and delivery. Maternal PlGF concentrations were lower in twin than singleton pregnancies at week 35 only [219.2 vs. 350.2 pg/mL; p<0.0001]. Placental weight appeared to be inversely correlated with maternal sFlt-1/PlGF ratio at the end of the pregnancy in both twins and singletons. Conclusions Higher maternal anti-angiogenic proteins in twin than singleton pregnancies does not appear to be due to greater placental mass in the former, and may be one explanation for the increased risk of preeclampsia in women carrying multiple gestations. Determining whether women with a history of multiple gestations have an altered cardiovascular disease and breast cancer risk, like those with a history of preeclampsia, is warranted.

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Angiogenic growth factors in maternal and fetal serum in concordant and discordant twin pregnancies

Abstract: Mothers of discordant twins have a more anti-angiogenic environment compared to those of concordant twins. We also found an anti-angiogenic environment in the small twin when we compared umbilical vein angiogenic factors against its big co-twin.

Cited by 10 publications

References 7 publications

Maternal serum sFlt‐1/PlGF ratio in twin pregnancies with and without pre‐eclampsia in comparison with singleton pregnancies

Maternal serum sFlt‐1/PlGF ratio in twin pregnancies with and without pre‐eclampsia in comparison with singleton pregnancies

Angiogenic factors: potential to change clinical practice in pre‐eclampsia?

Maternal circulating angiogenic factors in twin and singleton pregnancies

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