Angiogenin and apoptosis in hypertension in pregnancy

Karthikeyan, Vellore J; Lip, Gregory Y.H.; Lane, Deirdre A.; Blann, Andrew D.

doi:10.1016/j.preghy.2011.07.002

Cited by 6 publications

(2 citation statements)

References 70 publications

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“…It was found that ANG levels in serum of pregnant women with preeclampsia changed significantly, ANG levels of mild and severe preeclampsia patients are significantly higher than normal pregnant women, at last, increased ANG expression in placenta may also lead to low birth weight. Although still unclear increased maternal serum ANG is a cause or a result of maternal blood pressure increasing, but inhibition maternal serum ANG may be a way for the treatment of pregnancy-induced hypertension [36][37][38][39].…”

Section: Ang and Gestational Hypertensionmentioning

confidence: 99%

Research Progress of Angiogenin in Fertility and Reproduction Endocrinology

Huang

Yunxia

2019

COGO

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Angiogenin (ANG) was previously proved one of the potent proangiogenic factors in the process of formation, remodeling and maturation of new blood vessel, then was found playing a dual role in tumor growth by promoting both tumor angiogenesis and cancerous cell proliferation and promoting neuron neurite growth, recently it has been proved an important regulator in stem cell regeneration and stemness maintenance by affecting nucleic acid hydrolysis and protein synthesis. Here we review the related research about ANG in reproduction. ANG was detected in different levels of follicle except in primordial stage in bovine and human and reveals that it may play role in follicle development and mature. During pregnancy, large amount of ANG dramatically expressed in maternal, amniotic fluid or fetal placenta, it may play a role in embryo implantation, the growth and development of fetus. The occurrence of reproduction related diseases such as infertility, endometriosis, ovarian hyperstimulation syndrome, gestational hypertension, fetal growth retardation and etc seems related with ANG. However, detailed research on the mechanism of ANG in related diseases is lack. Therefore, the further study about the role of ANG is of great significance for the understanding ANG function and may bring promising treatment of fertility, reproduction related diseases.

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Section: Ang and Gestational Hypertensionmentioning

confidence: 99%

Research Progress of Angiogenin in Fertility and Reproduction Endocrinology

Huang

Yunxia

2019

COGO

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“…Recent studies suggested that TP 53 participates in human reproduction mainly through regulating leukemia inhibitory factor (LIF) levels[8]. Otherwise, apoptosis and angiogenesis have played a crucial role during the normal pregnancy development [9]. TP 53 codon 72 polymorphism (rs 1042522) is a vital functional polymorphic form which consists of either a wild C allele or a derived G allele.…”

Section: Introductionmentioning

confidence: 99%

Influence of TP53 Codon 72 Polymorphism Alone or in Combination with HDM2 SNP309 on Human Infertility and IVF Outcome

et al. 2016

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To evaluate the association of the TP53 codon 72 (rs 1042522) alone or in combination with HDM2 SNP309 (rs 2279744) polymorphisms with human infertility and IVF outcome, we collected 1450 infertility women undergoing their first controlled ovarian stimulation for IVF treatment and 250 fertile controls in the case-control study. Frequencies, distribution, interaction of genes, and correlation with infertility and IVF outcome of clinical pregnancy were analyzed. We found a statistically significant association between TP53 codon 72 polymorphism and IVF outcome (52.10% vs. 47.40%, OR = 0.83, 95%CI:0.71–0.96, p = 0.01). No significant difference was shown between TP53 codon 72, HDM2 SNP309 polymorphisms, human infertility, and between the combination of two genes polymorphisms and the clinical pregnancy outcome of IVF. The data support C allele as a protective factor for IVF pregnancy outcome. Further researches should be focused on the mechanism of these associations.

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Involvement of Renin-Angiotensin System Inhibition, the Potential Risk of Danshen in the Treatment of Pregnancy-Induced Hypertension

Liang

Su²

2015

Phytother. Res.

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Angiogenin and apoptosis in hypertension in pregnancy

Cited by 6 publications

References 70 publications

Research Progress of Angiogenin in Fertility and Reproduction Endocrinology

Research Progress of Angiogenin in Fertility and Reproduction Endocrinology

Influence of TP53 Codon 72 Polymorphism Alone or in Combination with HDM2 SNP309 on Human Infertility and IVF Outcome

Involvement of Renin-Angiotensin System Inhibition, the Potential Risk of Danshen in the Treatment of Pregnancy-Induced Hypertension

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