Angiogenin as a Molecular Target for the Treatment of Prostate Cancer

Li, Shuping; Ibaragi, Soichiro; Hu, Guobin

doi:10.2174/1573394711107020083

Cited by 27 publications

(14 citation statements)

References 62 publications

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“…As the increased resistance of cancer cells to glucose deficiency contributes positively to tumor progression [61], it is reasonable to hypothesize that FLS, through these mechanisms, could indirectly foster tumor development. On the other hand, these data further confirm the previous findings of the same authors [41] highlighting that in HeLa cells, FLS is present in the nucleus and may interact with angiogenin, a 14-kDa protein endowed with pro-angiogenic functions, including endothelial cell activation, which may also promote migration, invasion, proliferation, and formation of tubular structure [62][63][64]. Finally, FLS has been reported to bind to type III TGF-β [39].…”

Section: Follistatin In Prostate Cancer Progressionsupporting

confidence: 89%

Follistatin as potential therapeutic target in prostate cancer

et al. 2013

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Follistatin is a single-chain glycosylated protein whose primary function consists in binding and neutralizing some members of the transforming growth factor-β superfamily such as activin and bone morphogenic proteins. Emerging evidence indicates that this molecule may also play a role in the malignant progression of several human tumors including prostate cancer. In particular, recent findings suggest that, in this tumor, follistatin may also contribute to the formation of bone metastasis through multiple mechanisms, some of which are not related to its specific activin or bone morphogenic proteins' inhibitory activity. This review provides insight into the most recent advances in understanding the role of follistatin in the prostate cancer progression and discusses the clinical and therapeutic implications related to these findings.

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Section: Follistatin In Prostate Cancer Progressionsupporting

confidence: 89%

Follistatin as potential therapeutic target in prostate cancer

et al. 2013

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“…However, it was less clear how rRNAs are proportionally increased as they need to be incorporated with ribosomal proteins in an equal molar level to make a functional ribosome. In order to know whether rRNA transcription in cancer cells is modulated by ANG, a series of experiments using prostate cancer as a model has been performed to understand the role of ANG in rRNA transcription, ribosome biogenesis, and cell growth (Yoshioka et al, 2006; Ibaragi et al, 2009a, b; Li et al, 2011). Human ANG is significantly and progressively upregulated in prostate cancer (Majumder et al, 2003; Katona et al, 2005).…”

Section: Ang‐mediated Rrna Transcription In Cancer Cell Proliferationmentioning

confidence: 99%

“…ANG activity was therefore thought to be a requirement for excessive cancer cell proliferation as it provides the extra rRNA needed to sustain continuous growth. AKT and ANG pathways therefore mediate the production of ribosomal proteins and rRNAs, respectively, and a coordinated action of AKT and ANG allows ribosome biogenesis to take place (Li et al, 2011). Consistently, there is a crosstalk between AKT and ANG pathways (Fig.…”

Section: Ang‐mediated Rrna Transcription In Cancer Cell Proliferationmentioning

confidence: 99%

Emerging role of angiogenin in stress response and cell survival under adverse conditions

2012

Journal Cellular Physiology

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145

127

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Angiogenin (ANG), also known as ribonuclease (RNASE) 5, is a member of the vertebrate-specific, secreted RNASE superfamily. ANG was originally identified as a tumor angiogenic factor, but its biological activity has been extended from inducing angiogenesis to stimulating cell proliferation and more recently, to promoting cell survival. Under growth conditions, ANG is translocated to nucleus where it accumulates in nucleolus and stimulates ribosomal RNA (rRNA) transcription, thus facilitating cell growth and proliferation. Under stress conditions, ANG is accumulated in cytoplasmic compartments and modulates the production of tiRNA, a novel class of small RNA that is derived from tRNA and is induced by stress. tiRNA suppress global protein translation by inhibiting both cap-dependent and -independent translation including that mediated by weak IRESes. However, strong IRES-mediated translation, a mechanism often used by genes involved in pro-survival and anti-apoptosis, is not affected. Thus, ANG-mediated tiRNA reprogram protein translation, save anabolic energy, and promote cell survival. This recently uncovered function of ANG presents a novel mechanism of action in regulating cell growth and survival.

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“…Thus, previous studies have focused on its role in a possible antiangiogenin-based cure for cancer [37–39]. However, ANG is known to function as an antimicrobial peptide and is related to diverse inflammatory diseases and innate immunity [23, 28, 40–42].…”

Section: Discussionmentioning

confidence: 99%

Angiogenin Reduces Immune Inflammation via Inhibition of TANK-Binding Kinase 1 Expression in Human Corneal Fibroblast Cells

Lee

Kim

Min

et al. 2014

Mediators of Inflammation

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Angiogenin (ANG) is reportedly multifunctional, with roles in angiogenesis and autoimmune diseases. This protein is involved in the innate immune system and has been implicated in several inflammatory diseases. Although ANG may be involved in the anti-inflammatory response, there is no evidence that it has direct anti-inflammatory effects. In this study we sought to determine whether ANG has an anti-inflammatory effect in human corneal fibroblasts (HCFs) exposed to media containing tumor necrosis factor-alpha (TNF-α). We found that ANG reduced the mRNA expression of interleukin-1 beta (IL-1β), -6, -8 and TNF-α receptors (TNFR) 1 and 2. In contrast, ANG increased the mRNA expression of IL-4 and -10. Protein levels of TANK-binding kinase 1 (TBK1) were reduced by ANG in HCFs treated with TNF-α. Moreover, ANG diminished the expression of IL-6 and -8 and monocyte chemotactic protein- (MCP-) 1. The protein expression of nuclear factor-κB (NF-κB) was downregulated by ANG treatment. These findings suggest that ANG suppressed the TNF-α-induced inflammatory response in HCFs through inhibition of TBK1-mediated NF-κB nuclear translocation. These novel results are likely to play a significant role in the selection of immune-mediated inflammatory therapeutic targets and may shed light on the pathogenesis of immune-mediated inflammatory diseases.

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Angiogenin as a Molecular Target for the Treatment of Prostate Cancer

Cited by 27 publications

References 62 publications

Follistatin as potential therapeutic target in prostate cancer

Follistatin as potential therapeutic target in prostate cancer

Emerging role of angiogenin in stress response and cell survival under adverse conditions

Angiogenin Reduces Immune Inflammation via Inhibition of TANK-Binding Kinase 1 Expression in Human Corneal Fibroblast Cells

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