Angiogenin plasma levels during pregnancy

Kolben, M.; Bläser, Jörg; Ulm, K.; Schneider, K. T. M.; Tschesche, Harald; Graeff, H.

doi:10.1016/s0002-9378(97)80008-7

Cited by 27 publications

(29 citation statements)

References 20 publications

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“…The serum level of ANG increases in uncomplicated pregnancies, suggesting that ANG may play an important role in normal vascular development during the perinatal period [107,108]. Indeed, ANG is expressed during early human placental development [109].…”

Section: Ang Is Involved In Fetal Vascularization and Immune Tolerancementioning

confidence: 99%

Three decades of research on angiogenin: a review and perspective

Sheng¹,

Xu²

2016

ABBS

181

201

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As a member of the vertebrate-specific secreted ribonucleases, angiogenin (ANG) was first isolated and identified solely by its ability to induce new blood vessel formation, and now, it has been recognized to play important roles in various physiological and pathological processes through regulating cell proliferation, survival, migration, invasion, and/or differentiation. ANG exhibits very weak ribonucleolytic activity that is critical for its biological functions, and exerts its functions through activating different signaling transduction pathways in different target cells. A series of recent studies have indicated that ANG contributes to cellular nucleic acid metabolism. Here, we comprehensively review the results of studies regarding the structure, mechanism, and function of ANG over the past three decades. Moreover, current problems and future research directions of ANG are discussed. The understanding of the function and mechanism of ANG in a wide context will help to better delineate its roles in diseases, especially in cancer and neurodegenerative diseases.

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Section: Ang Is Involved In Fetal Vascularization and Immune Tolerancementioning

confidence: 99%

Three decades of research on angiogenin: a review and perspective

Sheng¹,

Xu²

2016

ABBS

181

201

View full text Add to dashboard Cite

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“…Moreover, labor stress did not affect either maternal or fetal serum angiogenin concentrations [16]. Fetal serum angiogenin levels were significantly lower than those in maternal serum in both vaginally and cesarean delivered neonates [16]. The onset of labor was not associated with an increase in plasma angiogenin levels in normal vaginal delivery, presumably due to the inhibition of angiogenin activity through existing human placental ribonuclease inhibitor, which binds to angiogenin and abolishes its activity [17].…”

Section: Introductionmentioning

confidence: 87%

“…However, little is known about the regulation of angiogenin synthesis at the tissue or cell level [15]. With respect to the plasma angiogenin levels during pregnancy, Kolben et al [16] reported that plasma angiogenin levels rose from 150 to 250 ng/ml between the 10th and 40th weeks of gestation. Moreover, labor stress did not affect either maternal or fetal serum angiogenin concentrations [16].…”

Section: Introductionmentioning

confidence: 99%

“…With respect to the plasma angiogenin levels during pregnancy, Kolben et al [16] reported that plasma angiogenin levels rose from 150 to 250 ng/ml between the 10th and 40th weeks of gestation. Moreover, labor stress did not affect either maternal or fetal serum angiogenin concentrations [16]. Fetal serum angiogenin levels were significantly lower than those in maternal serum in both vaginally and cesarean delivered neonates [16].…”

Section: Introductionmentioning

confidence: 99%

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Maternal and Fetal Circulating Angiogenin Levels in Pregnancies with Small-for-Gestational-Age and Appropriate-for-Gestational-Age Infants

Yamashiro

Ohnishi²,

Kanenishi³

et al. 2000

Gynecol Obstet Invest

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Objective: The objective of the present study was to evaluate whether maternal and fetal circulating angiogenin levels in pregnancies with small-for-gestational- age (SGA) infants are different from those in pregnancies with appropriate-for-gestational-age (AGA) infants. Methods: Maternal and fetal circulating angiogenin concentrations were compared at birth between 16 pregnancies with SGA (7 delivered vaginally and 9 delivered by elective cesarean section) and 46 pregnancies with AGA (27 delivered vaginally and 19 delivered by cesarean section). Serum angiogenin level was measured with an enzyme-linked immunosorbent assay. Results: There were no significant differences in maternal and fetal serum angiogenin levels between the two groups. However, maternal serum angiogenin levels were significantly higher than those in fetal serum within both SGA and AGA infant pregnancies. There were no significant differences in maternal and fetal serum angiogenin levels between vaginal and cesarean delivered pregnancies in both SGA and AGA groups. Conclusion: These results suggest that there is no difference in angiogenin synthesis between SGA and AGA pregnancies.

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“…주로 간세포에 서 생성되나, 그 외 표피세포, 섬유아세포, 또는 말초혈액세포에서도 생 성된다 [9,10]. 임신중에는 양수, 태반과 모체 혈청에서 검출된다 [11,12]. Angiogenin은 태반을 포함한 여러 조직에서 허혈성괴사가 있으면 그 생 성 정도에 변화가 나타나며, 영양막의 침윤과 태반의 발달에도 관여한 다 [13,14].…”

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Association of angiogenin and interleukin-6 levels in cervical discharge during early pregnancy, together with its outcome

Hyun

Jung

Shim

et al. 2011

Korean J Obstet Gynecol

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ObjectiveTo investigate the association between the cervical angiogenin and interleukin-6 levels and its outcome during early pregnancy. MethodsOne hundred and seventy-fi ve pregnant women were included consecutively at the time of their fi rst prenatal visit after less than 10 weeks of gestation. The gestational age was calculated according to their menstrual history and/or ultrasonography. We measured the cervical angiogenin and interleukin-6 levels using ELISA kits. We also measured the maternal serum progesterone concentrations using radioimmunoassay. Spontaneous abortion was defi ned as when a pregnancy ended spontaneously within 20 weeks of gestation. If an index pregnancy lasted longer than 20 weeks of gestation, it was regarded as showing a normal pregnancy outcome. ResultsFifty-four pregnancies were excluded because of an incomplete study (n=36) or follow-up loss (n=18). Of the remaining 121 pregnancies, spontaneous abortion occurred in 10 pregnancies (8.3%) in which there were no significant gestational agedependent changes in the maternal serum progesterone, cervical angiogenin, and interleukin-6 levels. The maternal serum progesterone, cervical angiogenin, and interleukin-6 levels were not signifi cantly different between the spontaneous abortion group and the normal control group. However, the cervical angiogenin level was significantly decreased in the groups with discordant gestational age and spontaneous abortion compared to the group with concordant gestational age (median, 798.0 pg/mL vs. 723.4 pg/mL vs. 1039.8 pg/mL; inter-quartile range, 222.8-1054.7 pg/mL vs. 257.1-1213.3 pg/mL vs. 480.4-1534.4 pg/mL) (P<0.041). ConclusionFirst trimester cervical angiogenin measurement may be valuable for predicting the early pregnancy outcome.

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Angiogenin plasma levels during pregnancy

Cited by 27 publications

References 20 publications

Three decades of research on angiogenin: a review and perspective

Three decades of research on angiogenin: a review and perspective

Maternal and Fetal Circulating Angiogenin Levels in Pregnancies with Small-for-Gestational-Age and Appropriate-for-Gestational-Age Infants

Association of angiogenin and interleukin-6 levels in cervical discharge during early pregnancy, together with its outcome

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