Angiographic and histological comparison of canine bifurcation aneurysms treated with first generation matrix and standard GDC coils

Abstract

Aneurysms treated with first-generation Matrix coils showed the greatest degree of coil compaction and aneurysm recurrence on the final angiographic evaluation. Aneurysms treated with first-generation Matrix coils showed enhanced thrombus organization and absence of vascular clefts at the aneurysm neck that were markedly different from those treated with bare platinum coils or a combination of GDC and Matrix coils.

In Vivo Experimental Intracranial Aneurysm Models: A Systematic Review

“…Angiographic outcomes at 3 or 6 months can be compared in the canine bifurcation aneurysm models, and with such end points, the value of 1 embolic device over another was shown in the past. 19,43,60 We must remember that even if better angiographic results in animals could be shown to predict better angiographic results in humans, these end points are surrogates for long-term efficacy in the prevention of ruptures.…”

“…68 Many investigators have published scales that offer a rational, if not a validated basis, for assessing the performance of an implant, by giving points for features considered favorable for healing, including neck coverage with neointima, thickness of neointimal layer, or clot organization at the dome. 11,19,[43][44][45][46][47]56,69 These semiquantitative scales have largely been confined to single-center experiences; they have not been reproduced or validated. No one, to our knowledge, has been able to show that these criteria predict better in vivo clinical performances, however.…”

“…28 Bifurcation aneurysm models in dogs and rabbits can show recurrences with variable frequencies, despite treatment with various types of devices. 12,13,16,28,[41][42][43] Angiographic recurrences are rarely documented after coil embolization of the rabbit elastase aneurysms, but "microrecurrences" (only seen at pathology) are common.…”

“…29,42,43 Among the 10 studies performed in bifurcation aneurysms in rabbits, 5 revealed a considerable discrepancy between radiologic and pathologic findings, with angiography overestimating the degree of occlusion in all cases. 8,18,30,31 Microscopic recurrences have been described with the rabbit elastase model, but a correlation with angiographic recurrences is rarely possible.…”

A Large and Giant Bifurcation Aneurysm Model in Canines: Proof of Feasibility

“…10,11 On the other hand, since the publication by German and Black, 1 canine venous pouch aneurysms have also been commonly utilized. 12,13 Their natural history was also studied and they also showed long-term patency, with few spontaneous thromboses or ruptures. [14][15][16] Giant aneurysms are still challenging for both traditional surgical and endovascular treatment.…”