Angiographic embolization followed by piecemeal resection of giant posterior mediastinal schwannoma: Case report and concise review

Loftus, Tyler J.; Pipkin, M.; Machuca, Tiago

doi:10.1016/j.ijscr.2018.10.055

Cited by 15 publications

(16 citation statements)

References 16 publications

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“…Few studies on these tumors have been published. 2,3 Our aim was to describe the clinical, radiological, and microscopic features of these tumors, based on a 12-year single-institution experience.…”

Section: Introductionmentioning

confidence: 99%

A single-institution experience of neurogenic tumors of the mediastinum

Mlika

Marghli

Souilem

et al. 2019

Asian Cardiovasc Thorac Ann

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Background Neurogenic tumors of the mediastinum are rare tumors located mainly in the posterior mediastinum. The aim of this study was to report a single-institution experience of these tumors. Methods This study was conducted between 2005 and 2017. Bivariate analysis was performed to assess correlations between the cellularity, mitotic index, presence of a capsule, and potential for malignancy of peripheral nerve sheath tumors. Results There were 86 patients enrolled in the study. The mean age was 42.51 years. Nineteen patients were asymptomatic and their tumors were discovered incidentally. Microscopic diagnosis confirmed a schwannoma in 45 cases, neurofibroma in 12, malignant peripheral nerve sheath tumor in 9, ganglioneuroma in 14, ganglioneuroblastoma in 4, and neuroblastoma in 2. Bivariate analysis showed a significant correlation between the absence of a capsule, the degree of atypia, a high mitotic index, and high cellularity with the potential for malignancy ( p < 0.05). Surgical resection was the main treatment modality in 84 cases. The mean survival was estimated to be 51.309 months. The log-rank test showed a significant difference in survival according to histologic subtype and between benign and malignant tumors ( p < 0.0001). Conclusion Even if radiologic means are helpful in suggesting the diagnosis, a positive diagnosis of neurogenic tumors is based on microscopic features. High mitotic activity and cellularity, and severe cytonuclear atypia are the features most suggestive of malignancy.

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Section: Introductionmentioning

confidence: 99%

A single-institution experience of neurogenic tumors of the mediastinum

Mlika

Marghli

Souilem

et al. 2019

Asian Cardiovasc Thorac Ann

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“…However, where available, it can be used when Iodine-131 or surgery is not desirable and when the nodule is not too large (<5 ml in volume) ( 7 , 8 ). Finally, pre-operative embolization of hypervascular thoracic, lumbar, and sacral spinal column tumors with polyvinyl alcohol particles has been linked to reduced intraoperative blood loss and improved qualitative variables such as visibility and resectability of the tumor ( 9 , 10 ). Alcohol ablation of the extracardiac tumor through a coronary artery branch has not been described in the published reports.…”

Section: Discussionmentioning

confidence: 99%

Alcohol Ablation of Extracardiac Thoracic Tumor

et al. 2019

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“…To the Editor, Neurogenic tumors are the common-est posterior mediastinal tumors accounting for 80% of all posterior mediastinal tumors. They originate from the spinal cord, sympathetic ganglia, or peripheral nerve roots 1 . A schwannoma is a slow-growing, encapsulated, and benign neurogenic tumor.…”

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confidence: 99%

“…Fewer than 9% of schwannomas are located in the mediastinum. Posterior mediastinal schwannomas originate from neural crest cells and typically originate from the intercostal nerves 1 . Mediastinal schwannomas are often asymptomatic but may present with cough or dyspnea 2 .…”

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confidence: 99%