Angiographic predictors of 2‐year stent thrombosis in patients receiving drug‐eluting stents: Insights from the ADAPT‐DES study

Abstract

Anatomically complex lesions and the presence of thrombus are strong predictors of 2-year ST in the DES era. © 2016 Wiley Periodicals, Inc.

Incidence, angiographic and clinical predictors, and impact of stent thrombosis: a 6-year survey of 6,545 consecutive patients

“…Consistent with previous reports [ 28 – 30 ], roughly 90% of cases of definite ST occurred in patients with complex coronary lesions. This could have several possible explanations: (1) complex lesions enhance the risk of delayed or incomplete stent strut endothelialisation or stent malapposition, which could trigger platelet activation; (2) in patients undergoing complex PCI, more stents and longer stents are implanted, both increasing the chance of thrombogeneity and potentially predisposing to the occurrence of ST; (3) patients who underwent complex PCI could have more advanced CAD and more comorbidities that lead to faster disease progression and sudden onset of alterations that make them prone to ST.…”

Role of residual acute stent malapposition in percutaneous coronary interventions

“…Despite technological progress in terms of stent/polymer/drug platform and implantation technique, stent thrombosis (ST) remains a rare but important cause of acute and late stent failure . Albeit the pathogenic mechanism underlying ST is likely multifactorial, some publications suggested that acute stent malapposition (ASM) could play a role in determining ST, while others focused on the relationship between persistent stent malapposition, regardless of whether acute or late acquired, and very late ST .…”

Two‐year outcomes after treatment of severely calcified coronary lesions with the orbital atherectomy system and the impact of stent types: Insight from the ORBIT II trial

“…Indeed, previous work already showed the relationship between bleeding events and complexity of CAD . It is therefore possible to speculate that patients in whom a BMS was chosen had comorbidities putting them at risk of bleeding if longer DAPT would have been given, and that these same comorbidities are also associated with the presence of more extensive and complex CAD, making PCI procedures longer and more complex .…”