Angiographic severity of coronary artery disease and cardiovascular risk in acute coronary syndrome in patients with metabolic syndrome

Widecka, Katarzyna; Safranow, Krzysztof; Lewandowski, Maciej; Przybycień, Krzysztof; Gorący, Jarosław; Kornacewicz-Jach, Zdzisława

doi:10.5603/kp.a2017.0259

Cited by 7 publications

(8 citation statements)

References 27 publications

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“…18,19,23 This claim could be elucidated in view of the fact that inflammation caused by this syndrome plays a critical role in the process of atherosclerosis, which causes more severe coronary artery disease, restenosis and severe angiographic stenosis based on objective finding such as Syntax and modified Gensini. 24,25 The other finding and most probably the main finding of this study is that MS is an independent predictor of 30-day mortality. A significant association between MS and a range of adverse cardiovascular events including mortality were noted in previous studies.…”

Section: Discussionmentioning

confidence: 59%

Prevalence and Impact of Metabolic Syndrome on Short-Term Prognosis in Patients with Acute Coronary Syndrome: Prospective Cohort Study

Fanta

Daba

Asefa

et al. 2021

DMSO

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Purpose: Despite the increasing burden of metabolic syndrome (MS) and ischemic heart disease in sub-Saharan Africa, data on the prevalence of MS among patients with acute coronary syndrome (ACS) from the regions are limited. Hence, this study is aimed to evaluate the prevalence and impact of MS on 30-day all-cause mortality in patients hospitalized with ACS. Patients and Methods: We prospectively assessed 176 ACS patients, who were admitted to two tertiary hospitals in Ethiopia. MS was diagnosed based on a harmonized definition of MS. In-hospital major adverse cardiovascular events (MACE) and 30-day mortality were recorded. Multivariable cox-regression was used to identify predictors of 30-day mortality. Results: Among 176 ACS patients enrolled, 62 (35.2%) had MS. Majority of the patients (62.5%) were male with the mean age of 56±11.9 years. ACS patients with MS were older, presented with atypical symptoms, and they had history of hypertension, diabetes, dyslipidemia and coronary artery disease compared to those without MS. MS was also significantly associated with in-hospital MACE (30.6% vs 17.5%; p= 0.046) and 30-day mortality [adjusted hazard ratio (AHR) = 3.25, 95% CI=1.72-6.15]. The other significant predictors of 30-day mortality were pre-hospital delay >12h (HR= 4.32, 95% CI=1.68-11.100), killip class ≥2 (HR=10.7, 95% CI= 2.54-44.95), and ejection fraction <40 (HR= 2.59 95% CI=1.39-4.84). Conclusion:The prevalence of MS among patients with ACS in Ethiopia is high. MS was significantly associated with high in-hospital MACE and it was an independent predictor of 30-day mortality. Initiating appropriate strategies on MS prevention and timely diagnosis of MS components could decrease the burden of ACS and improve patient's outcome.

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Section: Discussionmentioning

confidence: 59%

Prevalence and Impact of Metabolic Syndrome on Short-Term Prognosis in Patients with Acute Coronary Syndrome: Prospective Cohort Study

Fanta

Daba

Asefa

et al. 2021

DMSO

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“…Glucose and lipid metabolism are the two major processes involved in increasing the risk and severity of CAD. Abnormal metabolism affects activity of regulatory pathways, composition of the final product, degree of inflammation, and coronary-plaque formation, thus contributing to the development of CAD and accelerating occurrence of adverse cardiovascular events [29,30].…”

Section: Effects On Glucose and Lipid Metabolismmentioning

confidence: 99%

A Review of the Relationship Between CTRP Family and Coronary Artery Disease

Fan

Sun

2020

Curr Atheroscler Rep

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Purpose of Review In recent years, a family of adiponectin paralogs designated as C1q/TNF-related protein (CTRP) has attracted increasing attention. They are inflammatory adipocytokines mostly secreted from epicardial adipose tissue, which modulate the development and prognosis of coronary artery disease (CAD). This review summarizes the pathophysiological roles of individual members of the CTRP superfamily in the development of CAD. Recent Findings Recent studies have revealed how members of the CTRP family, CTRP1, CTRP3, CTRP5, CTRP9, CTRP12, and CTRP13, can influence both development and progression of CAD by modulating metabolic pathways, influencing immuno-inflammatory response, and regulating cardiovascular functions. Summary Research to date has not been sufficient to answer the specific mechanism of the CTRP family in the occurrence and development of CAD. This review explores the evidence of CTRP superfamily regulating different pathophysiology stages of CAD through the immuno-inflammation, glucose and lipid metabolism, and vascular endothelial function.

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“…The results of some studies failed to show significant differences in the severity of CAD, in patients with/without MS. 31 In other studies, in patients with MS, the inverse relation, with a lower incidence of triple-vessel disease, was noticed in comparison with those without MS. 24 However, other studies besides no significant differences in the number of stenosed arteries, between patients with/without MS, found significantly higher Gensini score, in those with MS. It confirms the more severe form of CAD in these patients.…”

Section: Discussionmentioning

confidence: 79%

“…Rezultati nekih istraživanja nisu pokazali postojanje značajnih razlika u težini koronarne bolesti između ispitanika sa/bez MS 31 . U drugim istraživanjima kod ispitanika sa MS zapažen je inverzan odnos sa manjom učestalošću trosudovne bolesti u poređenju sa onima bez MS 24 .…”

Section: Discussionunclassified

Influence of metabolic syndrome on coronary arteries features in people with myocardial infarction

Miljković¹

2020

Opšta medicina

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Uvod. Prethodna epidemiološka i klinička ispitivanja potvrdila su povezanost između metaboličkog sindroma i povećanog rizika za nastanak koronarne bolesti. Pokazana je značajna povezanost ovog sindroma sa angiografski težim lezijama koronarnih arterija. Cilj rada. Cilj rada je bio da ispitamo značaj i uticaj metaboličkog sindroma na težinu angiografskih promena koronarnih arterija kod bolesnika sa infarktom miokarda. Metod. Ispitivanjem su obuhvaćena 143 bolesnika sa infarktom miokarda, 81 (58,7±6,2) sa i 62 (54,9±10,3) bez metaboličkog sindroma (p<0,01). Kod svih ispitanika urađeni su klinički pregledi, antropometrijska merenja, laboratorijska i koronarografska dijagnostika. Za postavljanje dijagnoze metaboličkog sindroma korišćeni su kriterijumi Američkog udruženja za srce i Nacionalnog instituta za srce, pluća i krv. Rezultati. Osobe sa metabolićkim sindromom, u poređenju sa onima bez MS, imaju: jednosudovnu 8,6% vs 46,8% (p<0,001), dvosudovnu 25,9% vs 32,3% (p>0,05), trosudovnu 65,4% vs 21,0% (p<0,001), višesudovnu bolest 91,3% vs 53,2% (p<0,001). Od pojedinačnih koronarnih arterija, značajne stenoze nađene su kod ispitanika sa MS, u poređenju sa ispitanicima bez MS: LAD 88,9% vs 71,0% (p<0,01), LCX 64,2% vs 29,0% (p<0,01), RCA 80,2% vs 61,3% (p<0,01), LM 14,8% vs 1,6%. Zaključak. Pacijenti sa MS imaju teže angiografske promene na koronarnim arterijama sa većom učestalošću trosudovne i višesudovne bolesti i stenoza LAD, LCX, RCA, LM, u poređenju sa onima bez MS, što pokazuje da je MS značajan faktor rizika za nastanak i razvoj teže koronarne bolesti.

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Angiographic severity of coronary artery disease and cardiovascular risk in acute coronary syndrome in patients with metabolic syndrome

Cited by 7 publications

References 27 publications

Prevalence and Impact of Metabolic Syndrome on Short-Term Prognosis in Patients with Acute Coronary Syndrome: Prospective Cohort Study

Prevalence and Impact of Metabolic Syndrome on Short-Term Prognosis in Patients with Acute Coronary Syndrome: Prospective Cohort Study

A Review of the Relationship Between CTRP Family and Coronary Artery Disease

Influence of metabolic syndrome on coronary arteries features in people with myocardial infarction

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