Angiography of the Retina With Indocyanine Green

Hochheimer, Bernard F.

doi:10.1001/archopht.1971.01000010566014

Cited by 99 publications

(25 citation statements)

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“…First described in the early 1970s [13], the use of indocyanine green angiography has allowed better visualization of the choroid and has provided additional information not available from fluorescein angiography.…”

Section: Discussionmentioning

confidence: 99%

“…The introduction of new technologies for fundus visualization, however, has led to a re-evaluation of the role of indocyanine green in the diagnosis of many chorioretinal disorders [13, 14]. Indocyanine green is a dye that has several advantages over sodium fluorescein for use in choroidal angiography: it absorbs adn fluoresces in the near-infrared range, thereby enhancing visualization of the fluorescence through hemorrhages, exudates or normal ocular pigment; the large and highly protein-bound dye molecules do not leak extensively through the fenestrations of the choriocapillaris and do not obscure the underlying choroidal vessels, thus allowing better imaging of the choroid and other subretinal structures than with fluorescein angiography.…”

Section: Introductionmentioning

confidence: 99%

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Indocyanine Green Angiography in Fundus flavimaculatus

et al. 2000

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Purpose: To describe the characteristic findings of fundus flavimaculatus (Stargardt disease) as seen on indocyanine green angiography. Methods: Twelve eyes of 6 consecutive patients with fundus flavimaculatus were studied by fundus color photographs, fluorescein angiography and indocyanine green angiography. Results: Indocyanine green angiography allowed visualization of small, clearly demarcated areas in which hypofluorescence increased over time, leading eventually to a large reticular pattern with small areas of normal-appearing choroid encircled by a well-defined network of hypofluorescent curvilinear lesions. These hypofluorescent flecks were present in all 12 eyes but corresponded only partially to the yellow flecks visible on biomicroscopy of the fundus. The peripapillary area was well preserved on indocyanine green angiography and the periphery did not show any visible abnormalities. Conclusions: The hypofluorescent curvilinear areas visualized on indocyanine green angiography form a reticular pattern that is similar to the polygonal shape of the watershed zones between terminal choroidal arterioles, which supply the choriocapillaris. These dark areas may reflect choriocapillaris defects secondary to lysis of lipofuscin-engorged retinal pigment epithelial cells. The typical lesions of fundus flavimaculatus thus seem to be situated in areas of least vascular supply. Their absence in the peripapillary area, which benefits from anastomotic vascular connections, would support this hypothesis.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Indocyanine Green Angiography in Fundus flavimaculatus

et al. 2000

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“…ICG can be classified as a low-toxicity contrast agent because advert reactions after its intravenous injection are rather rare [1]. It is commonly used in ophthalmology for staining blood vessels on the retina [2,3]. It was also clinically utilized for testing the liver function because the dye is extracted from the body by methabolisation in the liver [4][5][6][7].…”

Section: Introductionmentioning

confidence: 99%

Neurotoxic effects of indocyanine green -cerebellar granule cell culture viability study

Toczyłowska

Ziemińska

Goch

et al. 2014

Biomed. Opt. Express

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Abstract:The aim of this study was to examine neurotoxicity indocyanine green (ICG). We assessed viability of primary cerebellar granule cell culture (CGC) exposed to ICG to test two mechanisms that could be the first triggers causing neuronal toxicity: imbalance in calcium homeostasis and the degree of oligomerization of ICG molecules. We have observed this imbalance in CGC after exposure to 75-125μΜ ICG and dose and application sequence dependent protective effect of Gadovist on surviving neurons in vitro when used with ICG. Spectroscopic studies suggest the major cause of toxicity of the ICG is connected with oligomers formation. ICG at concentration of 25 μM (which is about 4 times higher than the highest concentration of ICG in the brain applied in in-vivo human studies) is not neurotoxic in the cell culture. Orlock, and C. A. Puliafito, "Adverse reactions due to indocyanine green," Ophthalmology 101(3), 529-533 (1994). 2. B. F. Hochheimer, "Angiography of the retina with indocyanine green," Arch. Ophthalmol. 86(5), 564-565 (1971). 3. J. Fishbaugh, "Retina: indocyanine green (ICG) angiography," Insight 19(3), 30-32 (1994). 4. J. Caesar, S. Shaldon, L. Chiandussi, L. Guevara, and S. Sherlock, "The use of indocyanine green in the measurement of hepatic blood flow and as a test of hepatic function," Clin. Sci. 21, 43-57 (1961). 5. A. El-Desoky, A. M. Seifalian, M. Cope, D. T. Delpy, and B. R. Davidson, "Experimental study of liver dysfunction evaluated by direct indocyanine green clearance using near infrared spectroscopy," Br. J. Surg. 1005-1011 (1999). 6. T. Ishizawa, N. Fukushima, J. Shibahara, K. Masuda, S. Tamura, T. Aoki, K. Hasegawa, Y. Beck, M. Fukayama, and N. Kokudo, "Real-time identification of liver cancers by using indocyanine green fluorescent imaging," Cancer 115(11), 2491-2504 (2009 4998-5003 (2006). 17. T. L. Jackson, "Indocyanine green accused," Br. J. Ophthalmol. 89(4), 395-396 (2005). Reson. Imaging 14(6), 619-623 (1996). 77. D. E. Ray, J. B. Cavanagh, C. C. Nolan, and S. C. Williams, "Neurotoxic effects of gadopentetate dimeglumine: behavioral disturbance and morphology after intracerebroventricular injection in rats," AJNR Am. J. Neuroradiol. 17(2), 365-373 (1996). 78. X. Feng, Q. Xia, L. Yuan, X. Yang, and K. Wang, "Impaired mitochondrial function and oxidative stress in rat cortical neurons: implications for gadolinium-induced neurotoxicity," Neurotoxicology 31(4), 391-398 (2010). 79. M. P. Mattson and Y. Goodman, "Different amyloidogenic peptides share a similar mechanism of neurotoxicity involving reactive oxygen species and calcium," Brain Res. 676(1), 219-224 (1995). 86(8),

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“…Angiographic flow tracer methods using dyes have a long history 43,44 and have re-emerged as an important method to visualize wound perfusion using indocyanine green (ICG) fluorescence imaging. [45][46][47][48] Angiographic methods employ a contrast agent and track its distribution and transit time in the vascular bed of interest in order to visualize the lumen of larger vessels, track the supply and transit of blood to the capillary bed, and image lymphatic vessels.…”

Section: Indocyanine Green-angiographymentioning

confidence: 99%

“…64 Adverse reactions to ICG are rare, with pruritus and mild reactions such as nausea and vomiting occurring in about 0.15% of patients. 65 More severe reactions have been reported and some deaths have occurred during cardiac catheterization in conjunction with ICG administration. ICG extravasation is well-tolerated and resolves without complications.…”

Section: Indocyanine Green-angiographymentioning

confidence: 99%

Review of near-infrared methods for wound assessment

Sowa

Kuo²,

et al. 2016

J. Biomed. Opt

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Angiography of the Retina With Indocyanine Green

Cited by 99 publications

References 1 publication

Indocyanine Green Angiography in Fundus flavimaculatus

Indocyanine Green Angiography in Fundus flavimaculatus

Neurotoxic effects of indocyanine green -cerebellar granule cell culture viability study

Review of near-infrared methods for wound assessment

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