Angioid streaks and traumatic ruptures of Bruch's membrane.

Hagedoorn, A.

doi:10.1136/bjo.59.5.267

Cited by 33 publications

(17 citation statements)

References 1 publication

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“…6 ; 12 ; 41 ; 42 ; 61 Individuals who have angioid streaks and have traumatic brain injury have an increased likelihood of visual damage because the Bruch's membrane is weakened by the angioid streaks. 41 ; 47 Ultimately, CNV, the most serious complication of angioid streaks, can cause severe loss of visual acuity. 41 …”

Section: Retinal Abnormalities In β-Thalassemia Major and Intermediamentioning

confidence: 99%

Retinal abnormalities in β-thalassemia major

Dunaief

2016

Survey of Ophthalmology

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Patients with beta (β)-thalassemia (β-TM: thalassemia major, β-TI: thalassemia intermedia) have a variety of complications that may affect all organs, including the eye. Ocular abnormalities include retinal pigment epithelium degeneration, angioid streaks, venous tortuosity, night blindness, visual field defects, decreased visual acuity, color vision abnormalities, and acute visual loss. Patients with β-TM are transfusion dependent and require iron chelation therapy (ICT) in order to survive. Retinal degeneration may result from either retinal iron accumulation from transfusion-induced iron overload or retinal toxicity induced by ICT. Some who were never treated with ICT exhibited retinopathy, and others receiving ICT had chelator-induced retinopathy. We will focus on retinal abnormalities present in individuals with β-TM viewed in light of new findings on the mechanisms and manifestations of retinal iron toxicity.

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Section: Retinal Abnormalities In β-Thalassemia Major and Intermediamentioning

confidence: 99%

Retinal abnormalities in β-thalassemia major

Dunaief

2016

Survey of Ophthalmology

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“…Traumatic breaks of Bruch’s membrane are frequently followed by subretinal hemorrhages which can be easily misinterpreted as CNV. These hemorrhages appear usually next to the angioid streaks and sometimes disseminate into the macula 21,22…”

Section: Clinical Course Complicationsmentioning

confidence: 99%

Angioid streaks, clinical course, complications, and current therapeutic management

Georgalas¹

2008

TCRM

101

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Angioid streaks are visible irregular crack-like dehiscences in Bruch's membrane that are associated with atrophic degeneration of the overlying retinal pigmented epithelium. Angioid streaks may be associated with pseudoxanthoma elasticum, Paget's disease, sickle-cell anemia, acromegaly, Ehlers-Danlos syndrome, and diabetes mellitus, but also appear in patients without any systemic disease. Patients with angioid streaks are generally asymptomatic, unless the lesions extend towards the foveola or develop complications such as traumatic Bruch's membrane rupture or macular choroidal neovascularization (CNV). The visual prognosis in patients with CNV secondary to angioid streaks if untreated, is poor and most treatment modalities, until recently, have failed to limit the devastating impact of CNV in central vision. However, it is likely that treatment with antivascular endothelial growth factor, especially in treatment-naive eyes to yield favorable results in the future and this has to be investigated in future studies.

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“…Trauma to the head and eye should be avoided, because even slight impact can cause retinal haemorrhage 12. Patients should be advised to avoid contact sports and other activities that might result in normally minor eye or head trauma, for example boxing, rugby, American football, soccer.…”

Section: Discussionmentioning

confidence: 99%