Angioimmunoblastic Lymphadenopathy-Like T-Cell Lymphoma: Cutaneous Clinical Onset With Prominent Granulomatous Reaction

Suárez‐Vilela, Dimas; Izquierdo-García, Francisco Miguel

doi:10.1097/00000478-200305000-00015

Cited by 23 publications

(11 citation statements)

References 6 publications

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“…EBV‐positive cells are rarely demonstrated (Martel et al , 2000; Brown et al , 2001). A florid epithelioid or granulomatous reaction has been described in occasional cases, which may mimic sarcoidosis or an infectious process (Scarabello et al , 2002; Suarez‐Vilela & Izquierdo‐Garcia, 2003; Pujol et al , 2005; Jayaraman et al , 2006).…”

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confidence: 99%

Advances in the understanding and management of angioimmunoblastic T‐cell lymphoma

2010

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Summary Angioimmunoblastic T‐cell lymphoma (AITL) is a distinct peripheral T‐cell lymphoma (PTCL) entity with peculiar clinical and pathological features. The recent identification of follicular helper T (TFH) cell as the cell of origin of this neoplasm represents a major step in our understanding of the pathobiological characteristics of the disease and should, in the future, clarify the diagnostic criteria for AITL and help to delineate its spectrum, especially from PTCL, not otherwise specified (PTCL, NOS). Deciphering the pathogenesis of the disease is needed to identify targets for new therapies that are expected to improve the poor outcome of AITL patients, when treated with conventional chemotherapy regimens. In this respect, efforts will be needed to evaluate promising innovative therapies in prospective clinical trials.

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confidence: 99%

Advances in the understanding and management of angioimmunoblastic T‐cell lymphoma

2010

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“…Those observations suggested that immunohistochemical markers may be more specific than histological features of skin biopsies for characterizing T‐cell lymphoma. Molecular analysis would also seem to be of importance as many cases harbored clonal TCR gene rearrangements in cutaneous lesions . Whenever IGH gene rearrangement analysis was performed, we identified an abnormal and clonal B‐cell population in association …”

Section: Discussionmentioning

confidence: 97%

“…Non‐specific patterns include perivascular infiltrate of eosinophils or leukocytoclastic vasculitis without any atypical cells . Prominent granulomatous reaction may also be observed, sometimes mimicking infectious lesions . Other patterns are suggestive of cutaneous lymphoma and may present as sparse superficial perivascular or dense pleomorphic infiltrate with atypical lymphocytes .…”

Section: Discussionmentioning

confidence: 99%

Cutaneous localization of angioimmunoblastic T‐cell lymphoma may masquerade as B‐cell lymphoma or classical Hodgkin lymphoma: A histologic diagnostic pitfall

et al. 2018

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Background We report the cases of three patients presenting skin lesions whose biopsies showed nodular polymorphic infiltrates consisting of lymphocytes, plasma cells, histiocytes, eosinophils, B blasts, and Hodgkin Reed‐Sternberg (HRS)‐like cells. Two of them were initially diagnosed as classical Hodgkin lymphoma (cHL), on the other hand, the last one as a B‐cell lymphoma. All patients have been treated for angioimmunoblastic T‐cell lymphoma (AITL). Methods We performed a second review of the skin biopsies with further immunophenotypic molecular analyses. Scrupulous observation revealed, in the background of the three cases, atypical small to medium‐sized lymphocytes carrying a CD3+, CD4+ T‐cell phenotype and expressing PD1 and CXCL13 follicular helper T‐cell markers. The two lesions initially diagnosed as cHL showed scattered HRS‐like cells with CD30+, CD15+, PAX5+, CD20−, Epstein Barr Virus (EBV) + classical phenotype. The case initially diagnosed as B‐cell lymphoma showed a diffuse B‐cell proliferation associated with small B‐cell and medium to large‐sized B blasts that were positive for EBV. Conclusion Those cases highlighted that atypical T‐cells may be obscured by B‐cell proliferation mimicking cHL or B‐cell lymphoma in cutaneous localization of AITL and confirmed the requirement of collecting clinical information before performing a diagnosis.

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“…Clonal populations of T-cells are seen in 87% of cases and clonal B-cells can be found in up to 40–80% of cases (with only 5 cases tested from previous reports) 10,39 . Uncommon histologic presentations include granulomatous dermatitides 4,40 , an atypical linear IgA dermatosis form 40 , prurigo-like eruptions 41 , and rarely an epidermotropic form mimicking mycosis fungoides (MF) 42 .…”

Section: Discussionmentioning

confidence: 99%

Extranodal Marginal Zone Lymphoma–like Presentations of Angioimmunoblastic T-Cell Lymphoma

Kaffenberger

Haverkos

Tyler

et al. 2015

The American Journal of Dermatopathology

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Angioimmunoblastic T-cell lymphoma (AITL) is the second most common type of peripheral T-cell lymphoma (PTCL) worldwide, and in some countries the most common form. Clinically, AITL usually presents with systemic symptoms, diffuse lymphadenopathy, hepatosplenomegaly and common laboratory abnormalities such as hypergammaglobulinemia. Skin rashes are seen in 50–80% of patients. AITL derives follicular T-helper cells (TFH), that express germinal center markes and produces hyperactivation of B-cell seen in AITL. Although the histologic features of AITL in the skin could be similar to pathologic findings present in lymph node biopsies, we present herein 2 cases of AITL with histologic and immunophenotypic features that were somewhat suggestive of extranodal marginal zone lymphoma (MALT).Caution is urged to exclude the possibility of a systemic T-cell lymphoma such as AITL in cutaneous and lymph node B-cell proliferations.

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Angioimmunoblastic Lymphadenopathy-Like T-Cell Lymphoma: Cutaneous Clinical Onset With Prominent Granulomatous Reaction

Cited by 23 publications

References 6 publications

Advances in the understanding and management of angioimmunoblastic T‐cell lymphoma

Advances in the understanding and management of angioimmunoblastic T‐cell lymphoma

Cutaneous localization of angioimmunoblastic T‐cell lymphoma may masquerade as B‐cell lymphoma or classical Hodgkin lymphoma: A histologic diagnostic pitfall

Extranodal Marginal Zone Lymphoma–like Presentations of Angioimmunoblastic T-Cell Lymphoma

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