Angioimmunoblastic T‐cell lymphoma

Gene expression profiling identifies molecular subgroups among nodal peripheral T-cell lymphomas

“…Other main components of this signature were XBP1 and RUNX1. This signature is in accordance with a known distinctive feature of AIL lesions, which is the presence of an expanded B-cell population (Dogan et al, 2003). Overexpression of XBP1 suggests that this transcription factor could play a role in the development of B-cell hyperplasia in AIL lesions, since it is known to be a crucial factor influencing B-cell and plasma cell differentiation (Chauhan et al, 2003;Munshi et al, 2004;Shaffer et al, 2004).…”

“…In all, 10 samples in which reactive histiocytes were numerous and formed significant aggregates were qualified as 'histiocyte rich', including two samples in which atypical T cells were masked by huge amounts of histiocytes, corresponding to the definition of the so-called Lennert's lymphoma (Suchi et al, 1987). The diagnosis of AIL was considered on the basis of usually admitted criteria (Dogan et al, 2003). AIL samples that lacked one of these criteria were qualified as 'BL'.…”

Expression of CXCL13, a chemokine highly upregulated in germinal center T-helper cells, distinguishes angioimmunoblastic T-cell lymphoma from peripheral T-cell lymphoma, unspecified

“…Recent studies have suggested that a defining feature of angioimmunoblastic T-cell lymphoma may be its origin from germinal center T-helper cells. [2][3][4] Typically, the tumor cells of angioimmunoblastic T-cell lymphoma have a Thelper cell phenotype expressing CD3, CD4 and frequently CD10, similar to a subset of normal germinal center T-helper cells. 3 In early lymph node involvement by angioimmunoblastic T-cell lymphoma, the neoplastic T cells preferentially occupy the B-cell follicles and immediate perifollicular area, suggesting that the follicle center microenvironment plays a role in tumor development.…”

“…[2][3][4] Typically, the tumor cells of angioimmunoblastic T-cell lymphoma have a Thelper cell phenotype expressing CD3, CD4 and frequently CD10, similar to a subset of normal germinal center T-helper cells. 3 In early lymph node involvement by angioimmunoblastic T-cell lymphoma, the neoplastic T cells preferentially occupy the B-cell follicles and immediate perifollicular area, suggesting that the follicle center microenvironment plays a role in tumor development. 2,4,5 The expression of CXCL13 by angioimmunoblastic T-cell lymphoma, as documented in our recent publication, 6 provides another piece of evidence linking the tumor cells to germinal center T-helper cells.…”

Intrafollicular neoplasia/“in situ” lymphoma: A proposal for morphology and immunodiagnostic classification

“…These lymphomas include nodular lymphocyte predominant Hodgkin lymphoma (NLPHL) [8], angioimmunoblastic T-cell lymphoma (AITL) showing limited paracortical involvement [9,10], mantle cell lymphoma (MCL) [11], and cases of nodal marginal zone lymphoma [12] (see Fig. 1).…”