Angiokinase inhibition of VEGFR-2, PDGFR and FGFR and cell growth inhibition in lung cancer: Design, synthesis, biological evaluation and molecular docking of novel azaheterocyclic coumarin derivatives

Ahmed, Eman Y.; El-Serwy, Weam S; El‐Mansy, Mohamed F.; Serry, Aya M.; Salem, A. M.; Abdou, Andrew M.; Abdelrahman, Basel A.; Elsayed, Kenzi H.; Elaziz, Moaaz R. Abd

doi:10.1016/j.bmcl.2021.128258

Cited by 27 publications

(9 citation statements)

References 27 publications

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“…The Chinese version of the Anderson symptom Assessment scale (MDASI-C), the revised MDASI-C consists of three parts [ 19 ]. The first part assesses the severity of 13 common symptoms of cancer, such as drowsiness, fatigue, and pain, within 24 hours, with each score from 0 to 10, representing the range from “asymptomatic” to “the most severe imaginable”.…”

Section: Methodsmentioning

confidence: 99%

[Retracted] Effect of Family Participatory Nursing Model Based on WeChat Platform on Psychological Elasticity and Quality of Life of Patients with Lung Cancer

Fang

2022

BioMed Research International

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Objective. To explore the effect of family participatory nursing model based on WeChat platform on psychological elasticity and life quality of patients with lung cancer. Methods. One hundred patients with lung cancer treated in our hospital from February 2019 to April 2021 were enrolled. The patients were randomly assigned into control group and study group. The control group received routine nursing and the study group received family participatory nursing model based on WeChat platform. The scores of nursing satisfaction, self-feeling burden, symptom group assessment scale, family care index, and compliance and life quality were compared. Results. First of all, we compared the nursing satisfaction: the study group was very satisfied in 25 cases, satisfactory in 20 cases, general in 5 cases, the satisfaction rate was 100.00%; the control group was very satisfied in 14 cases, satisfactory in 17 cases, general in 13 cases, dissatisfied in 6 cases, and the satisfaction rate was 88.00%. Compared between the two groups, the nursing satisfaction in the study group was higher compared to the control group ( P < 0.05 ). Secondly, we compared the self-perceived burden, the emotional burden, physical burden, and economic burden and total scores of the study group were lower compared to the control group ( P < 0.05 ). Comparing the scores of symptom group evaluation scale, the scores of respiratory symptoms, fatigue symptoms, psychological and emotional symptoms, digestive tract symptoms, and nervous system symptoms in the study group were lower compared to the control group ( P < 0.05 ). In terms of the family care index of the two groups, the scores of fitness, cooperation, length, emotion, and intimacy in the study group were higher compared to the control group ( P < 0.05 ). Comparison of compliance, the study group was very compliant in 42 cases, compliant in 7 cases, noncompliant in 1 case, the compliance rate was 98.00%; the control group was very compliant in 24 cases, compliant in 20 cases, noncompliant in 6 cases, the compliance rate was 88.00%. The compliance rate in the study group was higher compared to the control group ( P < 0.05 ). Finally, we compared the scores of qualities of life. Before nursing, there exhibited no significant difference ( P > 0.05 ). The scores of physiological function, psychological function, social function, and health self-cognition in the study group were lower compared to the control group ( P < 0.05 ). Conclusion. The family participatory nursing model based on WeChat platform helps to facilitate the psychological elasticity and quality of life of patients with lung cancer and further promote patients’ self-care ability and compliance with lung cancer. It can also effectively enhance family care and nursing satisfaction; the nursing model is worth popularizing and applying in clinic.

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Section: Methodsmentioning

confidence: 99%

[Retracted] Effect of Family Participatory Nursing Model Based on WeChat Platform on Psychological Elasticity and Quality of Life of Patients with Lung Cancer

Fang

2022

BioMed Research International

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“…Among coumarin derivatives, compound 15 ( Scheme 6 ) did not show any Hsp90 inhibitory activities, but additional investigations revealed its ability to interrupt MAPK signaling pathway by inhibiting the level of p-ERK and p-MEK; this function would be useful in anticancer activities [ 90 ]. Blagg et al illustrated that the 4-hydroxyl and the 3′-carbamate functional groups of novobiocin have proven to be detrimental as their essential components for Hsp90 inhibitory activity by SAR studies.…”

Section: Hsp90 Inhibitorsmentioning

confidence: 99%

Heterocyclic Compounds as Hsp90 Inhibitors: A Perspective on Anticancer Applications

et al. 2022

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Heat shock proteins (Hsps) have garnered special attention in cancer therapy as molecular chaperones with regulatory/mediatory effects on folding, maintenance/stability, maturation, and conformation of proteins as well as their effects on prevention of protein aggregation. Hsp90 ensures the stability of various client proteins needed for the growth of cells or the survival of tumor cells; therefore, they are overexpressed in tumor cells and play key roles in carcinogenesis. Accordingly, Hsp90 inhibitors are recognized as attractive therapeutic agents for investigations pertaining to tumor suppression. Natural Hsp90 inhibitors comprising geldanamycin (GM), reclaimed analogs of GM including 17-AAG and DMAG, and radicicol, a natural macrocyclic antifungal, are among the first potent Hsp90 inhibitors. Herein, recently synthesized heterocyclic compounds recognized as potent Hsp90 inhibitors are reviewed along with the anticancer effects of heterocyclic compounds, comprising purine, pyrazole, triazine, quinolines, coumarin, and isoxazoles molecules.

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“…Coumarin derivatives are the heterocyclic compounds that contain the structure of 1,2-benzopyrone, widespread in nature as potent secondary metabolites with a variety of excellent pharmacological activities such as anti-inflammatory ( Grover and Jachak, 2015 ), antioxidation ( Singh et al, 2020 ), antibacterial ( Charmforoshan et al, 2022 ), antithrombosis ( Sashidhara et al, 2012 ), anti-HIV ( Xu et al, 2021 ) and antitumor ( Wu et al, 2020 ). Because of their outstanding antitumor activity and relatively low side effects ( Cai et al, 2013 ; Ahmed et al, 2021 ; de la Cruz-Concepción et al, 2021 ; Chu et al, 2022 ; Song et al, 2022 ), coumarin derivatives have attracted tremendous research interest. It was reported that the coumarin derivatives connected with dihydroartemisinic ( Figure 1A ) exhibited potent cytotoxicity against human colon and breast cancer cells through inhibition of carbonic anhydrase IX ( Yu et al, 2018 ).…”

Section: Introductionmentioning

confidence: 99%

Design, synthesis and anticancer activity studies of 3-(coumarin-3-yl)-acrolein derivatives: Evidenced by integrating network pharmacology and vitro assay

Chen

Cai

et al. 2023

Front. Pharmacol.

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Coumarin derivatives have diverse structures and show various significant biological activities. Aiming to develop more potent coumarin derivatives for cancer treatment, a series of coumarin acrolein hybrids were designed and synthesized by using molecular hybridization approach, and investigated for their antiproliferative activity against A549, KB, Hela and MCF-7 cancer cells as well as HUVEC and LO2 human normal cells. The results indicated that most of the synthesized compounds displayed remarkable inhibitory activity towards cancer cells but low cytotoxicity on normal cells. Among all the compounds, 5d and 6e were the most promising compounds against different cancer cell lines, especially for A549 and KB cells. The preliminary action mechanism studies suggested that compound 6e, the representative compound, was capable of dose-dependently suppressing migration, invasion and inducing significant apoptosis. Furthermore, the combined results of network pharmacology and validation experiments revealed that compound 6e induced mitochondria dependent apoptosis via the PI3K/AKT-mediated Bcl-2 signaling pathway. In summary, our study indicated compound 6e could inhibit cell proliferation, migration, invasion and promote cell apoptosis through inhibition of PI3K/AKT signaling pathway in human oral epidermoid carcinoma cells. These findings demonstrated the potential of 3-(coumarin-3-yl)-acrolein derivatives as novel anticancer chemotherapeutic candidates, providing ideas for further development of drugs for clinical use.

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Angiokinase inhibition of VEGFR-2, PDGFR and FGFR and cell growth inhibition in lung cancer: Design, synthesis, biological evaluation and molecular docking of novel azaheterocyclic coumarin derivatives

Cited by 27 publications

References 27 publications

[Retracted] Effect of Family Participatory Nursing Model Based on WeChat Platform on Psychological Elasticity and Quality of Life of Patients with Lung Cancer

[Retracted] Effect of Family Participatory Nursing Model Based on WeChat Platform on Psychological Elasticity and Quality of Life of Patients with Lung Cancer

Heterocyclic Compounds as Hsp90 Inhibitors: A Perspective on Anticancer Applications

Design, synthesis and anticancer activity studies of 3-(coumarin-3-yl)-acrolein derivatives: Evidenced by integrating network pharmacology and vitro assay

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