Angioleiomyoma of Uterus: A Clinicopathologic Study of 6 Cases

Gupta, Mayank; Suryawanshi, Mayur; Kumar, Ramani; Peedicayil, Abraham

doi:10.1177/1066896917731516

Cited by 14 publications

(13 citation statements)

References 14 publications

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“…Another case we report is a cervical AL, of which we could find only three case reports reported in the literature so far [ Table 2 ]. [ 1 3 4 ] None of them showed a lipomatous component in contrast to our case (Case 2) where it is present, making it the first cervical AL of its kind.…”

Section: Introductioncontrasting

confidence: 76%

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Angioleiomyoma of Uterus and Cervix

Seth

Mathur

2021

Journal of Mid-Life Health

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Section: Introductioncontrasting

confidence: 76%

“…Uterine AL is quite a rare entity, and as per our search, only 38 case reports have been described in the literature so far [ Table 1 ]. Out of them, only a very few have been described as a polypoid uterine angioleiomomatous lesion,[ 1 2 ] which makes our case (Case 1) rarer.…”

Section: Introductionmentioning

confidence: 99%

Angioleiomyoma of Uterus and Cervix

Seth

Mathur

2021

Journal of Mid-Life Health

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“…Cavernous ALM comprises only a small amount of smooth muscles and diffuse, dilated vascular channels (5). Upon IHC analyses, most ALMs were positive for SMA, desmin, calponin, h-caldesmon, vimentin and collagen type IV (7,11). The vascular endothelial cells were positive for CD31 and CD34 (12).…”

Section: Discussionmentioning

confidence: 99%

Mediastinal cavernous angioleiomyoma: A case report and review of literature

Zuo

et al. 2022

Exp Ther Med

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Angioleiomyoma is a type of pericyte tumor with a benign biological behavior. It typically features proliferation of mature perivascular smooth muscle cells around blood vessels. Angioleiomyoma may be categorized into solid, cavernous or venous subtypes. Usually, it occurs in the dermis or subcutaneous tissue, while the rare cavernous subtype is most common in the upper extremities. Only a small number of cases of angioleiomyoma located in the mediastinum have been reported to date. In addition, there are few reports of mediastinal angioleiomyoma described as a cavernous histopathological subtype. The present study reported a case of mediastinal angioleiomyoma presenting as an unusual cavernous histopathological subtype. The histopathological and immunohistochemical features, based on which a diagnosis of cavernous angioleiomyoma was confirmed, were desmin-and smooth muscle actin-positive expression in spindle tumor cells, as well as ETS-related gene (ERG)-and CD31-positive expression in vascular endothelial cells. Cavernous angioleiomyoma of the mediastinum rarely occurs in the clinical setting but should be considered as a differential diagnosis of mediastinal tumors.

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“…Aynı tümörde sağ altta kavernöz varyantı temsil eden dilate kan damarı (siyah ok) ile solda venöz varyantı temsil eden kalın duvarlı damar kesitleri (mavi ok) ve arada düz kas demetleri (Hex40). (11,12). Uterin ALM, sıklıkla uterus korpusundan kaynaklanan iyi tanımlanmış tek bir kitle olarak ortaya çıkar.…”

Section: Resim 2 İntervasküler Düz Kas Demetlerinden Kolayca Ayırt Edilebilen Kalın Cidarlı Damar Kesitleri (Siyah Ok) Içeren Venöz Varyunclassified

Uterine angioleiomyoma: clinicopathological evaluation of 5 cases

Söğütçü

Oğlak

2020

Jinekoloji-Obstetrik Ve Neonatoloji Tıp Dergisi

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Aim: Uterine angioleiomyoma (ALM) is a very rare benign perivascular neoplasm. In this study, clinicopathologic and immunohistochemical features and treatment modalities of the cases were evaluated with a comprehensive literature review. Methods: 5 cases of uterine ALM admitted to the pathology department of our hospital were found in the pathology database. Hematoxylin-Eosin (HE) stained preparations of the cases were removed from the archive and reviewed. Immunohistochemical markers, namely muscle-specific actin, h-caldesmon, desmin, CD10, melan-A, HMB-45 and WT-1, were done. Results: The mean age of the patients was 40 years. Abnormal uterine bleeding and abdominal pain were the cause of admission in all patients. In one case (multiple ALM ), infertility was also present. A single tumour mass was observed in 4 cases, while multiple tumours focus (2 separate tumour focuses) were present in one case. The smallest tumour size was 5.2 cm, and the largest was 10 cm. The tumour was submucosal in one case and intramural in four cases. Macroscopically, all cases were sharp-edged, solid, white-grey, with a vortex nodular appearance. Two cases had solid and venous variants, one had venous and cavernous variants, one had venous variants, and one had all three variants. All cases were stained with desmin, h-caldesmon, smooth muscle actin; Staining with CD10, melan-A, HMB-45 and WT-1 was not observed. Conclusion: Uterine ALM is a rare, benign tumour and preoperative diagnosis is very difficult since there are no specific imaging findings. Therefore, it is crucial for the clinician and pathologist to remember this rare tumour and to distinguish it from similar ones.

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Angioleiomyoma of Uterus: A Clinicopathologic Study of 6 Cases

Abstract: As the World Health Organization has not included angioleiomyoma in the classification of mesenchymal tumors of uterine corpus and cervix, we recommend that it should be included in the classification.

Cited by 14 publications

References 14 publications

Angioleiomyoma of Uterus and Cervix

Angioleiomyoma of Uterus and Cervix

Mediastinal cavernous angioleiomyoma: A case report and review of literature

Uterine angioleiomyoma: clinicopathological evaluation of 5 cases

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