Angiolymphatic invasion exerts a strong impact on surgical outcomes for stage I lung adenocarcinoma, but not non-adenocarcinoma

Kato, Tatsuya; Ishikawa, Kenji; Aragaki, Masato; Sato, Masaaki; Okamoto, Ken‐ichi; Ishibashi, Tetsuya; Kaji, Mitsuhito

doi:10.1016/j.lungcan.2012.04.002

Cited by 31 publications

(19 citation statements)

References 20 publications

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“…In our study group, peritumoral lymphovascular invasion was determined to be statistically higher in patients with tumors larger than 3 cm, contrary to the findings by Kato et al 22 On the other hand, peritumoral lymphovascular invasion was found to be significantly higher in patients with pleural involvement, similar to findings by Kato et al…”

supporting

confidence: 52%

“…In a study conducted by Kato et al, 22 the presence of angiolymphatic invasion was not found to have a major impact on patients with tumors larger than 3 cm, but angiolymphatic invasion was found to have a clinical impact in the same patient group if those patients also had accompanying pleural involvement. In our study group, peritumoral lymphovascular invasion was determined to be statistically higher in patients with tumors larger than 3 cm, contrary to the findings by Kato et al 22 On the other hand, peritumoral lymphovascular invasion was found to be significantly higher in patients with pleural involvement, similar to findings by Kato et al…”

mentioning

confidence: 87%

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Clinical and Pathologic Prognostic Factors That Are Influential in the Survival and Prognosis of Lung Adenocarcinomas and Invasive Predominant Subtypes

Zeybek

Toru

Özbudak

et al. 2013

International Surgery

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Therapeutic approaches to lung adenocarcinomas differ because of their heterogeneous morphologies, prognoses, and clinical features. For this reason, new histopathologic classifications for lung adenocarcinomas were done by the International Association for the Study of Lung Cancer/American Thoracic Society/European Respiratory Society to form subtypes with homogeneous prognoses. There are limited clinical data in the literature on the prognosis of the subgroups formed according to the new classification. A total of 86 patients with adenocarcinoma who had undergone pathologic stages I and II curative resection and mediastinal lymph node dissection were retrospectively analyzed according to the seventh TNM staging system revised by the Union for International Cancer Control/American Joint Committee on Cancer. Histologic subtyping was reassessed according to the dominant histopathologic morphology. When survival rates of lung adenocarcinomas were compared according to their localizations, it was observed that adenocarcinomas localized to the right hemithorax had a longer survival than the ones with left hemithorax localization (P = 0.026). When necrosis was taken into account, it was seen that necrosis rate was higher in solid predominant type compared with other types, whereas it was lower in acinary type (P = 0.046). When peritumoral lymphovascular invasion data were assessed, it was observed that disease-free survival was influenced in a negative fashion (P = 0.018). New histopathologic classification of adenocarcinomas has been a step forward to attaining homogeneous groups, but when the biologic heterogeneity of the adenocarcinomas is taken into account, the authors believe that considering the peritumoral lymphatic vascular invasion, left hemithorax localization, and tumoral necrosis entities in the upcoming TNM classification will contribute to evaluating the prognosis.

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confidence: 52%

mentioning

confidence: 87%

Clinical and Pathologic Prognostic Factors That Are Influential in the Survival and Prognosis of Lung Adenocarcinomas and Invasive Predominant Subtypes

Zeybek

Toru

Özbudak

et al. 2013

International Surgery

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“…Most lung cancer treatment failures occur within the first 2 years after surgery (Poleri et al, 2003), and once metastasis occurs, the survival rate is generally less than 3 years (Kato et al, 2012). A total of 10 (52.63%; 10/19) patients suffered from tumor metastasis in the first 2 years after their operation in the LVI+ group, and in the LVI-group, tumor metastasis only occurred in 3 (18.75%; 3/16) patients; this difference was statically significant, with a P value less than 0.05.…”

Section: Discussionmentioning

confidence: 99%

Clinical significance of lymphatic vessel invasion in stage I non-small cell lung cancer patients

Ma¹,

Chu²,

Liu³

2015

Genet. Mol. Res.

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ABSTRACT. The aim of this retrospective study was to evaluate the prognostic influence of lymphatic vessel invasion (LVI) in stage I non-small cell lung cancer (NSCLC) patients. From January 2004 to December 2007, LVI was detected in 57 patients with T1N0M0 NSCLC; therefore, 114 patients with the same pathology, T stage, and surgery method, but without LVI, were selected as the control group to compare survival. The overall survival and relapse-free survival rates were estimated using the Kaplan-Meier method, log-rank test, and Cox proportional hazards analysis. The average follow-up length was 59.94 ± 23.1 months. The 5-year overall survival rates of the LVI-negative and the LVI-positive groups were 90.54 and 70.1%, respectively (P = 0.002). A multivariate analysis revealed LVI to be an independent predictive factor (hazard ratio = 4.562; P = 0.004). The 5-year overall survival rates for patients who received postoperative adjunctive therapy and those who did not in the LVI-positive group were 88.2 and 61.5%, respectively, with a P value less than 0.05 in both univariate and multivariate analyses. LVI is a poor prognostic factor in stage I NSCLC patients; postoperative adjunctive therapy is needed to improve the 1820 K.F. Ma et al.

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“…There is a close relationship between histology appearances and gene mutations. Other predictors for pathologic stage I lung adenocarcinoma are clinicopathologic parameters, such as tumor size (4,16), TNM stage (4,13), aerogenous spread (5,9), tumor differentiation (4), bronchial involvement (4), lymphovascular invasion (4,18,23,26), positive thyroid transcription factor-1 (TTF-1) expression (19,28), lepidic growth pattern (16), sex (16), age (22), tumor budding (14), pleural invasion (29), carcinoembryonic antigen levels (30), and standardized uptake value (SUV) index (<1.0) (25).…”

Section: Risk Factors Of Postoperative Outcomes In Pathologic Stage Imentioning

confidence: 99%

Prognostic factors of patients with pathologic stage I lung adenocarcinoma

Chen

Huang

2018

J. Thorac. Dis.

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Angiolymphatic invasion exerts a strong impact on surgical outcomes for stage I lung adenocarcinoma, but not non-adenocarcinoma

Cited by 31 publications

References 20 publications

Clinical and Pathologic Prognostic Factors That Are Influential in the Survival and Prognosis of Lung Adenocarcinomas and Invasive Predominant Subtypes

Clinical and Pathologic Prognostic Factors That Are Influential in the Survival and Prognosis of Lung Adenocarcinomas and Invasive Predominant Subtypes

Clinical significance of lymphatic vessel invasion in stage I non-small cell lung cancer patients

Prognostic factors of patients with pathologic stage I lung adenocarcinoma

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